Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology,
Год журнала:
2023,
Номер
15(2), С. 529 - 561
Опубликована: Окт. 29, 2023
Background:
Thousands
of
people
have
already
died
as
a
result
the
2019
coronavirus
disease
pandemic
(COVID-19),
which
was
brought
on
by
SARS-CoV-2
coronavirus.There
were
many
unimaginable
cases
illness
in
Washington
2020
first
case,
and
then
it
transmitted
to
Wuhan,
Germany,
France,
Italy,
Spain,
United
Kingdom
China.The
newly
discovered
SARS-CoV,
MERS-CoV,
are
believed
be
natural
not
laboratory
synthetic.The
COVID-19
may
due
contamination
infected
objects
with
materials
that
spread
across
world.Main
body:
Human
infection
symptoms
can
range
from
being
asymptomatic
fatal,
including
respiratory
failure,
multiple
organ
dysfunction,
death.Large-scale
genetic
association
studies
demonstrated
immune
system
components
such
interferons,
interleukins,
toll-like
receptors,
human
leukocyte
antigen
well
receptor
variations
(angiotensinconverting
enzymes,
transmembrane
serine
protease-2)
important
host
determinants
severity.Conclusion:
The
current
review
aims
demonstrate
factors
affect
severity.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 23, 2023
To
analyze
the
potential
impact
of
sociodemographic,
clinical
and
biological
factors
on
long-term
cognitive
outcome
patients
who
survived
moderate
severe
forms
COVID-19.We
assessed
710
adult
participants
(Mean
age
=
55
±
14;
48.3%
were
female)
6
to
11
months
after
hospital
discharge
with
a
complete
battery,
as
well
psychiatric,
laboratory
evaluation.
A
large
set
inferential
statistical
methods
was
used
predict
variables
associated
any
impairment,
focus
panel
28
cytokines
other
blood
inflammatory
disease
severity
markers.Concerning
subjective
assessment
performance,
36.1%
reported
slightly
poorer
overall
14.6%
being
severely
impacted,
compared
their
pre-COVID-19
status.
Multivariate
analysis
found
sex,
age,
ethnicity,
education,
comorbidity,
frailty
physical
activity
general
cognition.
bivariate
that
G-CSF,
IFN-alfa2,
IL13,
IL15,
IL1.RA,
EL1.alfa,
IL45,
IL5,
IL6,
IL7,
TNF-Beta,
VEGF,
Follow-up
C-Reactive
Protein,
D-Dimer
significantly
(p<.05)
However,
LASSO
regression
included
all
follow-up
variables,
markers
did
not
support
these
findings.Though
we
identified
several
sociodemographic
characteristics
might
protect
against
impairment
following
SARS-CoV-2
infection,
our
data
do
prominent
role
for
status
(both
during
acute
long-stage
COVID-19)
or
background
(also
explain
deficits
can
follow
COVID-19
infection.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 835 - 835
Опубликована: Июль 11, 2024
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID’s
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 5, 2024
Abstract
We
aimed
to
characterize
the
cognitive
profile
of
post-acute
COVID-19
syndrome
(PACS)
patients
with
complaints,
exploring
influence
biological
and
psychological
factors.
Participants
confirmed
SARS-CoV-2
infection
complaints
≥
8
weeks
phase
were
included.
A
comprehensive
neuropsychological
battery
(NPS)
health
questionnaires
administered
at
inclusion
1,
3
6
months.
Blood
samples
collected
each
visit,
MRI
scan
baseline
months,
and,
optionally,
cerebrospinal
fluid.
Cognitive
features
analyzed
in
relation
clinical,
neuroimaging,
biochemical
markers
follow-up.
Forty-nine
participants,
a
mean
time
from
symptom
onset
10.4
showed
attention-executive
function
(69%)
verbal
memory
(39%)
impairment.
Apathy
(64%),
moderate-severe
anxiety
(57%),
severe
fatigue
(35%)
prevalent.
Visual
(8%)
correlated
total
gray
matter
(GM)
subcortical
GM
volume.
Neuronal
damage
inflammation
within
normal
limits.
Over
time,
test
scores,
depression,
apathy,
indexes,
fluid
biomarkers
remained
stable,
although
fewer
participants
(50%
vs.
75.5%;
p
=
0.012)
exhibited
abnormal
evaluations
Altered
attention/executive
memory,
common
PACS,
persisted
most
subjects
without
association
structural
abnormalities,
elevated
cytokines,
or
neuronal
markers.
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID's
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
