Expression of miR-155 in monocytes of people with migraine: association with phenotype, disease severity and inflammatory profile

The Journal of Headache and Pain, Год журнала: 2024, Номер 25(1)

Опубликована: Авг. 26, 2024

miR-155 is involved in the generation and maintenance of inflammation pain, endothelial function immune system homeostasis, all functions that are relevant for migraine. The present study aims to assess levels migraine subtypes (episodic chronic) comparison age- sex-matched healthy controls.

Язык: Английский

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Circulating miRNAs as Potential Biomarkers Distinguishing Relapsing–Remitting from Secondary Progressive Multiple Sclerosis. A Review

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11887 - 11887

Опубликована: Ноя. 2, 2021

Multiple sclerosis (MS) is a debilitating neurodegenerative, highly heterogeneous disease with variable course. The most common MS subtype relapsing–remitting (RR), having interchanging periods of worsening and relative stabilization. After decade, in RR patients, it alters into the secondary progressive (SP) phase, one no clear remissions, leading to disability deterioration. Among greatest challenges for clinicians understanding progression molecular mechanisms, since mainly characterized by inflammatory processes, while SP, neurodegeneration prevails. This especially important because distinguishing from SP early will enable faster implementation appropriate treatment. Currently, course not well-correlated biomarkers routinely used clinical practice. Despite many studies, there are still reliable indicators correlating stage its activity degree. Circulating microRNAs (miRNAs) may be considered valuable molecules diagnosis and, presumably, helpful predicting subtype. MiRNA expression dysregulation commonly observed Moreover, knowledge diverse miRNA panel between RRMS SPMS allow deterring through successful Therefore, this review, we address current state research on differences phases.

Язык: Английский

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Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron

Brain Sciences, Год журнала: 2023, Номер 13(7), С. 1073 - 1073

Опубликована: Июль 14, 2023

Multiple sclerosis (MS) is a chronic autoimmune and neuroinflammatory disease of the central nervous system characterized by peripheral activation immune-inflammatory pathways which culminate in neurotoxicity causing demyelination neurons. Nonetheless, pathophysiology relapsing-remitting MS (RRMS)-related fatigue, depression, anxiety, cognitive impairments, autonomic disturbances not well understood.The current study aims to delineate whether remitted phase RRMS accompanied activated if latter, coupled with erythron variables, explain fatigue mood symptoms due RRMS.We recruited 63 patients, 55 8 secondary progressive MS, 30 healthy controls assessed used bio-plex assay measure 27 serum cytokines.A significant proportion patients (46%) displayed response (IRS) compensatory immune (CIRS) systems, T helper (Th)1 Th17 cytokine profiles. Remitted showed increased physiosomatic, autonomic, insomnia scores, could partly be explained M1 macrophage, Th1, Th-17, growth factor, CIRS activation, as aberrations including lowered hematocrit hemoglobin levels.Around 50% show association chronic-fatigue-like symptoms. IRS are new drug targets treat affective MS.

Язык: Английский

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Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 22

Опубликована: Сен. 1, 2022

Background/Aims. Multiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS) primarily hallmarked by neuroinflammation and demyelination. The activation of astrocytes exerts double-edged sword effects, which perform integral function in demyelination remyelination. In this research, we examined therapeutic effects Bu Shen Yi Sui capsule (BSYS), a traditional Chinese medicine prescription, cuprizone- (CPZ-) triggered model MS (CPZ mice). This research intended to evaluate if BSYS might promote remyelination shifting A1 A2 astrocytes. Methods. on astrocyte polarization potential mechanisms were explored vitro vivo utilizing real-time quantitative reverse transcription PCR, immunofluorescence, Western blotting. Histopathology, expression inflammatory cytokines (IL-10, IL-1β, IL-6), growth factors (TGF-β, BDNF), motor coordination assessed verify (3.02 g/kg/d) CPZ mice. vitro, induced TNF-α (30 ng/mL), IL-1α (3 C1q (400 following effect BSYS-containing serum (concentration 15%) transformation A1/A2 reactive was also evaluated. Results Conclusions. treatment improved mice as rotarod tests. Intragastric administration considerably lowered proportion astrocytes, but number MOG+, PLP+, CNPase+, MBP+ cells upregulated. Meanwhile, dysregulation glutathione peroxidase, malondialdehyde, superoxide dismutase reversed after with BSYS. addition, lesion area proinflammatory decreased neuronal protection anti-inflammatory increased. suppressed astrocytic markers' elevated levels markers primary C1q, TNF-α, IL-1α. Importantly, miR-155/SOCS1 signaling pathway involved modulation phenotype shift. Overall, study demonstrated has neuroprotective myelin repair modulating via pathway.

Язык: Английский

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miRNAs in treatment-resistant depression: a systematic review

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Май 10, 2024

Язык: Английский

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