Biomedicines,
Год журнала:
2023,
Номер
11(5), С. 1341 - 1341
Опубликована: Май 2, 2023
An
enriched
environment
stimulates
adult
hippocampal
plasticity,
but
the
exact
cellular
and
molecular
mechanisms
are
complex,
thus
a
matter
of
debate.
We
studied
behavior
neurogenesis
in
male
female
Wistar
rats
that
were
housed
an
(EE)
for
two
months.
Both
EE
males
females
performed
better
than
control
animals
Barnes
maze,
meaning
enhances
spatial
memory.
However,
expression
levels
markers
KI67,
DCX,
Nestin,
Syn1
increased
only
females,
while
KI67
BDNF
higher
corresponding
control.
The
number
DCX+
neurons
on
brain
slices
dentate
gyrus
only,
i.e.,
level
was
not
rats.
anti-inflammatory
IL-10
signaling
pathway
components
upregulated
females.
Of
84
miRNAs
tested,
hippocampi
we
detected
upregulation
12
related
to
neuronal
differentiation
morphogenesis,
four
involved
regulation
cell
proliferation/differentiation,
one
downregulated
associated
with
stimulation
proliferation.
Taken
altogether,
our
results
point
sex-specific
differences
expression,
miRNA
profiles
induced
by
environment.
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
36, С. 100729 - 100729
Опубликована: Янв. 23, 2024
Communication
among
the
brain,
gut
and
microbiota
in
is
known
to
affect
susceptibility
stress,
but
mechanisms
involved
are
unclear.
Here
we
demonstrated
that
stress
resistance
mice
was
associated
with
more
abundant
Progress in Neurobiology,
Год журнала:
2022,
Номер
217, С. 102333 - 102333
Опубликована: Июль 21, 2022
The
neurotrophin
brain-derived
neurotrophic
factor
(BDNF)
stimulates
adult
neurogenesis,
but
also
influences
structural
plasticity
and
function
of
serotonergic
neurons.
Both,
BDNF/TrkB
signaling
the
system
modulate
behavioral
responses
to
stress
can
lead
pathological
states
when
dysregulated.
two
systems
have
been
shown
mediate
therapeutic
effect
antidepressant
drugs
regulate
hippocampal
neurogenesis.
To
elucidate
interplay
both
at
cellular
levels,
we
generated
a
transgenic
mouse
line
that
overexpresses
BDNF
in
neurons
an
inducible
manner.
Besides
displaying
enhanced
hippocampus-dependent
contextual
learning,
mice
were
less
affected
by
chronic
social
defeat
(CSDS)
compared
wild-type
animals.
In
parallel,
observed
axonal
sprouting
dentate
gyrus
increased
neural
stem/progenitor
cell
proliferation,
which
was
uniformly
distributed
along
dorsoventral
axis
hippocampus.
forced
swim
test,
BDNF-overexpressing
behaved
similarly
as
treated
with
fluoxetine.
Our
data
suggest
released
from
projections
exerts
this
partly
enhancing
Furthermore,
independently
genotype,
neurogenesis
positively
correlated
interaction
time
after
CSDS,
measure
for
resilience.
Neuroscience Research,
Год журнала:
2022,
Номер
unknown
Опубликована: Авг. 1, 2022
The
dentate
gyrus
(DG)
of
the
hippocampus
has
been
implicated
in
regulation
stress
responses,
and
pathophysiology
treatment
depression.
This
review
discusses
cellular
changes
caused
by
chronic
role
DG
stress-induced
behavioral
its
antidepressant-like
effects.
Regarding
adult-born
neurogenic
processes
DG,
stress,
such
as
repeated
social
defeat,
suppresses
cell
proliferation
during
immediately
after
stress;
however,
this
effect
is
transient.
subsequent
differentiation
survival
are
differentially
regulated
depending
on
timing
sensitivity
stress.
activation
young
neurons
contributes
to
resilience,
while
transient
increase
cessation
seems
promote
susceptibility.
In
mature
granule
neurons,
predominant
cells
synaptic
plasticity
suppressed
However,
a
group
activated
Chronic
antidepressant
can
transform
phenotype
resembling
that
immature
characterized
"dematuration".
Adult-born
suppress
indicating
local
neural
interactions
within
important
for
response.
Elucidating
stress-associated
context-
timing-dependent
functions
will
provide
insights
into
stress-related
psychiatric
diseases.
Neurosciences,
Год журнала:
2025,
Номер
30(1), С. 5 - 19
Опубликована: Янв. 1, 2025
The
hippocampus,
noted
as
(HC),
plays
a
crucial
role
in
the
processes
of
learning,
memory
formation,
and
spatial
navigation.
Recent
research
reveals
that
this
brain
region
can
undergo
structural
functional
changes
due
to
environmental
exposures,
including
stress,
noise
pollution,
sleep
deprivation,
microgravity.
This
review
synthesizes
findings
from
animal
human
studies,
emphasizing
HC's
plasticity
response
these
factors.
It
examines
volume,
architecture,
neurogenesis,
synaptic
plasticity,
gene
expression
highlights
critical
periods
vulnerability
influences
impacting
cognition
behavior.
also
investigates
underlying
mechanisms
such
glucocorticoid
signaling,
epigenetic
alterations,
neural
circuit
adaptations.
Understanding
how
HC
reacts
various
exposures
is
vital
for
developing
strategies
enhance
cognitive
resilience
mitigate
negative
effects
on
region.
Further
needed
identify
protective
risk
factors
create
effective
interventions.
Psychiatric
disorders
have
been
reported
to
influence
many
health
outcomes,
but
evidence
about
their
impact
on
chronic
kidney
disease
(CKD)
has
not
fully
explored,
as
well
possible
mechanisms
implicated
are
still
unclear.
Four
hundred
forty-one
thousand
eight
ninety-three
participants
from
UK
Biobank
were
included
in
this
study.
To
assess
the
association
between
psychiatric
mainly
including
depression,
anxiety,
stress-related
disorders,
substance
misuse
psychotic
disorder,
and
CKD,
a
Cox
regression
model
using
age
underlying
time
scale
was
employed.
This
approach
considers
progression
of
beginning
end
study
elapsed
time.
Flexible
nonparametric
smoothing
conducted
illustrate
temporal
patterns.
Subgroup
analyses
performed
by
stratification
gender,
genetic
susceptibility
at
entry
or
exit
cohort,
follow-up
duration,
number
baseline.
Mediation
analysis
implemented
evaluate
roles
body
mass
index
(BMI),
hypertension,
diabetes.
Compared
with
individuals
without
an
increased
risk
CKD
observed
patients
(hazard
ratios
(HR)
=
1.52,
95%
confidence
intervals
(CI):
1.40–1.65,
p-value
<
0.001).
The
hazard
ratio
among
gradually
increased,
became
significant
after
10
years
follow-ups.
HR
for
followed
up
10–12
1.60
(95%
CI:
1.34–1.91,
0.001),
1.66
1.29–2.13,
0.001)
12–13
years.
Five
distinct
found
be
significantly
associated
developing
CKD.
highest
disorder
(HR
1.95,
95%CI:
1.28–2.97,
0.002).
When
adjusting
1.86
(95%CI:
1.14–3.04,
0.013).
Although
these
associations
nominally
significant,
they
did
reach
statistical
significance
applying
Bonferroni
multiple
corrections,
potentially
due
limited
sample
size.
revealed
that
who
under
60,
morbidities
having
diagnosed
over
may
high-risk
populations.
Hypertension,
BMI
diabetes
mediated
49.13%
37.60%-67.08%),
12.11%
8.49%-17.24%)
3.78%
1.58%-6.52%)
total
effect,
respectively.
delayed
onset
elevated
only
more
than
Our
highlights
lifestyle
interventions,
routine
monitoring
function,
early
screening
personalized
management
strategies
potential
approaches
precise
prevention
