Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1507 - 1507
Опубликована: Ноя. 26, 2024
Stroke
is
an
often
underrecognized
albeit
significant
complication
in
patients
with
brain
cancer,
arising
from
the
intricate
interplay
between
cancer
biology
and
cerebrovascular
health.
This
review
delves
into
multifactorial
pathophysiological
framework
linking
to
elevated
stroke
risk,
particular
emphasis
on
crucial
role
of
neurotoxic
microenvironment
(NTME).
The
NTME,
characterized
by
oxidative
stress,
neuroinflammation,
blood–brain
barrier
(BBB)
disruption,
creates
a
milieu
that
promotes
sustains
vascular
neuronal
injury.
Key
pathogenic
factors
driving
cancer-related
include
hypercoagulability,
inflammatory
immunological
mechanisms,
other
tumor-associated
processes,
including
direct
tumor
compression,
infection-related
sequelae,
treatment-related
complications.
Recent
advances
genomic
proteomic
profiling
present
promising
opportunities
for
personalized
medicine,
enabling
identification
biomarkers—such
as
oncogenes
suppressor
genes—that
predict
susceptibility
inform
individualized
therapeutic
strategies.
Targeting
NTME
through
antioxidants
alleviate
anti-inflammatory
agents
mitigate
therapies
aimed
at
reinforcing
BBB
could
pave
way
more
effective
prevention
management
integrative
approach
holds
potential
reduce
both
incidence
severity
stroke,
ultimately
improving
clinical
outcomes
quality
life
patients.
Further
research
well-designed
trials
are
essential
validate
these
strategies
integrate
them
routine
practice,
thereby
redefining
risk
Brain Sciences,
Год журнала:
2023,
Номер
13(3), С. 415 - 415
Опубликована: Фев. 27, 2023
Understanding
the
transmission
pathways
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
will
aid
in
developing
effective
therapies
directed
at
virus’s
life
cycle
or
its
side
effects.
While
distress
is
most
common
symptom
a
2019
(COVID-19)
infection,
virus
also
known
to
cause
damage
almost
every
major
organ
and
system
body.
However,
it
not
obvious
whether
pathological
changes
extra-respiratory
organs
are
caused
by
direct
indirect,
combination
these
In
this
narrative
review,
we
first
elaborate
on
characteristics
SARS-CoV-2,
followed
mechanisms
various
such
as
brain,
eye,
olfactory
nerve
different
systems
endocrine
gastrointestinal
systems.
Brazilian Journal of Health Review,
Год журнала:
2024,
Номер
7(2), С. e68209 - e68209
Опубликована: Март 20, 2024
O
SARS
-
Cov-2
é
um
beta
coronavírus,
cujo
potencial
mutacional
e
transmissional
o
fez
protagonizar
a
pandemia
da
COVID-19.
Apesar
de
ocasionar
predominantemente
quadros
assintomáticos
ou
com
sintomas
leves,
surgem
exceções
em
que
doença
progride
requisitando
maiores
medidas
intervenção.
Nessas
circunstâncias,
dificuldade
recuperação
provém
incapacidade
do
sistema
imune
eliminar
as
células
infectadas,
além
sua
estimulação
desregulada,
culmina
uma
reação
inflamatória
exacerbada,
linfohistiocitose
hemofagocítica.
objetivo
presente
artigo
descrever
correlação
agravamento
sistêmico
COVID-
19
devido
hemofagocítica
suas
implicações.
Trata-se
revisão
bibliográfica
integrativa
literatura,
qual
embasada
artigos
indexados
produzidos
entre
os
anos
2019
2024,
nos
idiomas
inglês
espanhol,
booleano
AND
para
cruzamento
descritores
na
plataforma
Biblioteca
Virtual
Saúde
(BVS).
A
hemofagocítica,
manifestação
clínica
tempestade
citocinas,
apresenta-se
tanto
forma
primária
quanto
secundária
(adquirida).
Está
ligada
à
proliferação
disruptiva
dos
leucócitos,
singular
linfócitos
macrófagos,
acarretando
liberação
citocinas
mediadores
químicos.
Assim,
delineia-se
cascata
ações
defesa
que,
quando
excesso
influenciam
favorecendo
agravo
quadro
COVID,
desdobrando
panorama
possibilidades
tratamentos
imunomoduladores
entendimentos
funcionamento
resposta
inflamatória.
Seminars in Ultrasound CT and MRI,
Год журнала:
2024,
Номер
45(4), С. 332 - 338
Опубликована: Июль 10, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
responsible
for
the
debilitating
global
pandemic
known
as
Coronavirus
disease
(COVID-19).
In
this
paper,
we
highlight
widespread
manifestations
and
complications
across
systems.
addition,
present
their
relevant
imaging
findings
to
inform
appropriate
investigations
management
in
patients
presenting
Emergency
Department
with
COVID-19
its
respective
sequalae.
Of
note,
outline
considerations
diagnosis
of
long
COVID,
an
important
medium
term
sequalae
previous
infections.
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1507 - 1507
Опубликована: Ноя. 26, 2024
Stroke
is
an
often
underrecognized
albeit
significant
complication
in
patients
with
brain
cancer,
arising
from
the
intricate
interplay
between
cancer
biology
and
cerebrovascular
health.
This
review
delves
into
multifactorial
pathophysiological
framework
linking
to
elevated
stroke
risk,
particular
emphasis
on
crucial
role
of
neurotoxic
microenvironment
(NTME).
The
NTME,
characterized
by
oxidative
stress,
neuroinflammation,
blood–brain
barrier
(BBB)
disruption,
creates
a
milieu
that
promotes
sustains
vascular
neuronal
injury.
Key
pathogenic
factors
driving
cancer-related
include
hypercoagulability,
inflammatory
immunological
mechanisms,
other
tumor-associated
processes,
including
direct
tumor
compression,
infection-related
sequelae,
treatment-related
complications.
Recent
advances
genomic
proteomic
profiling
present
promising
opportunities
for
personalized
medicine,
enabling
identification
biomarkers—such
as
oncogenes
suppressor
genes—that
predict
susceptibility
inform
individualized
therapeutic
strategies.
Targeting
NTME
through
antioxidants
alleviate
anti-inflammatory
agents
mitigate
therapies
aimed
at
reinforcing
BBB
could
pave
way
more
effective
prevention
management
integrative
approach
holds
potential
reduce
both
incidence
severity
stroke,
ultimately
improving
clinical
outcomes
quality
life
patients.
Further
research
well-designed
trials
are
essential
validate
these
strategies
integrate
them
routine
practice,
thereby
redefining
risk
