Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 12, 2025

Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types offer strong regenerative potential, making them promising for treating various diseases. However, issues with immune response survival limit effectiveness transplantation. This has led increased interest in cell-free therapy, particularly use exosomes, which is most studied form this approach. Exosomes are extracellular vesicles that contain proteins, lipids, nucleic acids play key role communication material exchange. Pyroptosis, death involved innate immunity, also associated many Studies have shown MSC-derived exosomes therapeutic potential range conditions by regulating inflammation pyroptosis. study explored modulating pyroptosis improve bone-related

Язык: Английский

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Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 19, 2025

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in field of biosciences for their role intercellular communication various physiological and pathological processes. Their ubiquitous presence bodily fluids cell-specific characteristics make them promising candidates as biomarkers. Additionally, ability to transport biological therapeutics across different barriers specific target underscores significant translational potential diagnostic therapeutic purposes. Significant progress has been achieved translation EVs research clinical applications, however, challenges persist large-scale production EVs, particularly areas scalable manufacturing, efficient isolation methods, drug loading techniques, advanced characterization technology. This review critically examines complex processes involved biogenesis explores recent developments production. By synthesizing knowledge from these fields, this aims provide a holistic perspective on evolving landscape its underscoring both accomplishments obstacles that lie ahead fully realizing biomedicine.

Язык: Английский

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Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Journal of Cosmetic Dermatology, Год журнала: 2022, Номер 21(8), С. 3226 - 3231

Опубликована: Апрель 20, 2022

Abstract Background Alopecia is a common chief complaint and challenging to treat. As such, regenerative treatments promote hair growth are an emerging area of research. Exosomes, which extracellular vesicles involved in cell communication, homeostasis, differentiation, organogenesis, have been shown play central role morphogenesis regeneration with potential for use as alopecia treatment. Aims This review summarizes assesses the body literature surrounding exosomes therapeutics identifies areas improvement future Methods A was conducted using comprehensive list keywords including “exosome,” “alopecia,” “hair loss” on PubMed, EMBASE, Google Scholar databases published from inception February 2022. Reference lists identified articles were included. 47 studies Clinical trial searched term “exosome”; however, no trials relevant identified. Results Our updated details history exosome medicine, postulated underlying mechanisms treating loss, current clinical studies. Preclinical demonstrate clear benefits medicine loss safety but data showing efficacy therapy lacking. We several gaps knowledge required effective translation safety, source, optimal treatment delivery mechanism dosage. Conclusion Exosomes horizon exciting therapeutic alopecia. Further required.

Язык: Английский

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Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target

Metabolites, Год журнала: 2023, Номер 13(4), С. 479 - 479

Опубликована: Март 27, 2023

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival recovery rates for patients with CVD. Despite this progress, there substantial residual CVD risk an unmet need better treatment. The complex multifaceted pathophysiological mechanisms underlying development pose a challenge researchers seeking effective therapeutic interventions. Consequently, exosomes have emerged as new focus because their role intercellular communicators gives them potential to act noninvasive diagnostic biomarkers nanocarriers. heart vasculature, cell types such cardiomyocytes, endothelial cells, vascular smooth muscle, cardiac fibroblasts, inflammatory resident stem cells are involved homeostasis via release exosomes. Exosomes encapsulate cell-type specific miRNAs, miRNA content fluctuates response setting heart, indicating that pathways affected by these differentially expressed miRNAs may be targets treatments. This review discusses number evidence supports relevance latest technologies applying exosomal vesicles cargo delivery vehicles gene therapy, tissue regeneration, repair described.

Язык: Английский

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The role of microfluidics and 3D-bioprinting in the future of exosome therapy

Trends in biotechnology, Год журнала: 2023, Номер 41(11), С. 1343 - 1359

Опубликована: Июнь 9, 2023

Язык: Английский

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