Gene, Год журнала: 2023, Номер 896, С. 148029 - 148029
Опубликована: Ноя. 24, 2023
Язык: Английский
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Фев. 19, 2024
Obesity has become one of the global epidemics, contributing to burden disease in society, increasing risk diabetes, cardiovascular and liver diseases. Inadequate energy balance resulting from excessive intake insufficient physical activity (PA) is main factors incidence obesity development metabolic syndrome (MetS). Treatment options for include lifestyle modifications, pharmacotherapy bariatric surgery, with latter being most effective treatment. Lifestyle interventions involving increased PA reduced caloric improve outcomes. Early implementation exercise leads improved fitness, better glycemic control lipid profile. Undertaking systematic associated quality life, improves insulin sensitivity, causes additional weight loss, reduces its adverse effects on bone mass results body composition. In this narrative review we summarized current state knowledge impact components MetS latest recommendations patients MetS.
Язык: Английский
Процитировано
26
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Апрель 1, 2023
Abstract Background The impact of integrated lifestyles on health has attracted a lot attention. It remains unclear whether adherence to low-risk healthy lifestyle factors is protective in individuals with metabolic syndrome and syndrome-like characteristics. We aimed explore what extent overall scores mitigate the risk all-cause mortality Methods In total, 6934 participants from 2007 2014 National Health Nutrition Examination Survey (NHANES) were included. weighted score was constructed based smoking, alcohol consumption, physical activity, diet, sleep duration, sedentary behavior information. Generalized linear regression models restricted cubic splines used analyze association between mortality. Results Compared relatively low scores, ratio (RR) middle group 0.51 (RR = 0.51, 95% CI 0.30–0.88) , high 0.26 0.26, 0.15–0.48) population syndrome. difference gender persists. females, RRs groups 0.47 0.47, 0.23–0.96) 0.21 0.21, 0.09–0.46), respectively. males, by contrast, effect more pronounced 0.33, 0.13–0.83) effects found be likely. those aged < 65 years. Higher associated prominent effects, regardless presence one factor or combination several 15 groups. What's more, an emerging than that conventional lifestyle. Conclusions Adherence can reduce people characteristics; higher score, obvious effect. Our study highlights modification as highly effective nonpharmacological approach deserves further generalization.
Язык: Английский
Процитировано
27
Redox Biology, Год журнала: 2023, Номер 67, С. 102889 - 102889
Опубликована: Сен. 19, 2023
Maternal diets during pregnancy and lactation are key determinants that regulate the development of metabolic syndrome (MetS) in offspring. l-malic acid (MA) was previously reported to improve antioxidant capacity aerobic metabolism. However, effects maternal MA consumption on features offspring remain largely unexplored. Herein, through pig models consuming MA-enriched late lactation, we found potentiated anti-inflammatory sows, thereby improving their reproductive performance growth piglets. also induced a transition slow-twitch fast-twitch fibers early life Along with muscle fiber-type transition, insulin sensitivity glucose metabolism, including metabolism glycolysis, were improved skeletal An untargeted metabolomic analysis further revealed contribution modified amino Mechanistically, remodeled colonic microbiota Briefly, abundance Colidextribacter, Romboutsia, Family_XIII_AD3011_group increased, which positively associated muscles. A decreased Prevotella, Blautia, Prevotellaceae_NK3B31_group, Collinsella detected, involved less sensitivity. Notably, milk metabolites, such as ascorbic (AA) granisetron (GS), effectors regulating gut composition The properties AA GS alleviating resistance, inflammation, oxidative stress verified mice treated high-fat diets. Overall, this study could modulate inflammatory response, capacity, by vertical transmission metabolites. These findings suggest potential prevention treatment MetS life.
Язык: Английский
Процитировано
24
Clinical Nutrition, Год журнала: 2024, Номер 43(6), С. 1433 - 1446
Опубликована: Апрель 22, 2024
The prevalence of childhood and adolescent obesity has globally reached alarming dimensions many adolescents affected by already present one or more obesity-related comorbidities. In recent years, emerging evidence supporting the role gut microbiota in pathophysiology metabolic diseases been reported use prebiotics, probiotics, synbiotics postbiotics as a strategy to manipulate become popular. aim this review is explore relationship between syndrome discuss potential for prevention treatment clinical picture adolescence. According most literature, probiotics have no clear effect on MetS, but possible modulation anthropometric parameters observed after synbiotic supplementation. Only study examined alleviating complications children with not adolescents. More extensive research needed support conclusions drawn so far develop effective microbiome-based interventions that may help improving quality life exposed increasing MetS.
Язык: Английский
Процитировано
9
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
9
British Journal of Sports Medicine, Год журнала: 2024, Номер unknown, С. bjsports - 108481
Опубликована: Сен. 10, 2024
Objective To assess the effectiveness of high-intensity interval training (HIIT) compared with traditional moderate-intensity continuous (MICT) and/or non-exercise control (CON) for modification metabolic syndrome (MetS) components and other cardiometabolic health outcomes in individuals MetS. Design Systematic review meta-analysis Data sources Five databases were searched from inception to March 2024. Study appraisal synthesis Meta-analyses randomised controlled trials (RCTs) comparing HIIT MICT/CON performed MetS (waist circumference (WC), systolic blood pressure (SBP), diastolic (DBP), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting glucose (BG)) clinically relevant parameters. Subgroup moderator analyses conducted based on intervention duration volume. Results Out 4819 studies, 23 RCTs involving 1374 participants included (mean age: 46.2–67.0 years, 55% male). significantly improved WC (weighted mean difference (WMD) –4.12 cm, 95% CI –4.71 –3.53), SBP (WMD –6.05 mm Hg, –8.11 –4.00), DBP –3.68 –5.70 –1.65), HDL-C 0.12 mmol/L, 0.04 0.20), TG –0.34 –0.41 –0.27) BG –0.35 –0.54 –0.16) CON (all p<0.01). approaches demonstrated comparable effects MICT across all suggested that protocols low volume (ie, <15 min exercise per session) not inferior higher improving components. Conclusion This supports as an efficacious strategy Low-volume appears be a viable alternative forms aerobic exercise.
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2022, Номер 11(11), С. 2108 - 2108
Опубликована: Окт. 26, 2022
Metabolic syndrome (MetS) is a worldwide public health issue characterized by set of risk factors for cardiovascular disease. MetS can originate in early life developmental programming. Increasing evidence suggests that oxidative stress, which as an imbalance between reactive oxygen species (ROS), nitric oxide (NO), and antioxidant systems, plays decisive role Results from human animal studies indicate maternal-derived insults induce later life, accompanied stress programming various organ systems. On the contrary, perinatal use antioxidants offset thereby prevent traits adult offspring. This review provides overview current knowledge about core mechanisms behind programming, with particular focus on occurrence oxidative-stress-related pathogenesis well potential oxidative-stress-targeted interventions reprogramming strategy to avert origins. Future clinical should provide important proof concept effectiveness these epidemic.
Язык: Английский
Процитировано
20
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(7), С. 1856 - 1856
Опубликована: Март 27, 2022
Metabolic syndrome (MS) is closely linked to obesity; however, not all individuals with obesity will develop obesity-related complications and a metabolically healthy (MHO) group also described.To perform multivariate analysis (MVA) of the anthropometric biochemical data in pediatric patients reveal "phenotype" predictive for MS.We analyzed 528 children (OB) 119 normal-weight (NW). Adiposity indices were recorded, MS was detected. MVA performed.Analysis structure correlation variables showed that waist circumference (WC), body mass index (BMI), estimated fat (eFM) positively correlated each other as whole. In addition, triglycerides (TG), triglyceride-glucose (TyG) index, visceral adiposity whole, although none BMI z-score, waist-to-height ratio, WC, eFM, or weight. The related insulin resistance (IR) dyslipidemia crucial early stratification at risk MS.Independently weight, IR, dyslipidemia, hypertriglyceridemia, distribution seem be strongest factors. detection intervention these modifiable factors are useful protect children's health.
Язык: Английский
Процитировано
19
iScience, Год журнала: 2025, Номер 28(2), С. 111848 - 111848
Опубликована: Янв. 23, 2025
Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation oxidative stress, leading to the concept of "metabolic-cognitive syndrome." This highlights their mutual influence potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged a promising adjunct for prevention management these preclinical conditions. review examines clinical translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms MetS MCI. By addressing inflammation, metabolic dysfunction, supplements may offer valuable approach mitigating progression consequences both Understanding efficacy could provide practical tools complement changes, offering more comprehensive strategy managing metabolic-cognitive syndrome.
Язык: Английский
Процитировано
0
Journal of Diabetes Investigation, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
To exam the role of miR-92a/KLF2/miR-483 in pathogenesis metabolic syndrome. In this study, serum healthy controls and patients with syndrome were collected to detect circulating level miR-92a miR-483. vitro cultured HUVECs, overexpression or suppression miR-92a, miR-483 KLF2 determine relationship among Ang II, ox-LDL, high glucose treatment used mimic HUVECs HepG2 cells treated Telmisartan, Atorvastatin, metformin, its target gene expression was detected. animal experiment, ob/ob mice chose confirm changes KLF2, Compared controls, significantly increased, while remarkably decreased HUVECS, reduced miR-483, but had no effect on miR-92a. Overexpression could downregulate level, inhibition opposite effect. When stimulated ox-LDL glucose, genes increased. Anti-miR-92a reverse Furthermore, Metformin increased expression, which be reversed by mimic. The cells, exosomes derived from endothelial overexpression. showed similar effects. Endothelial dysfunction fatty liver are critically involved MicroRNAs can mediate cellular communication between vascular (ECs) distal cell. Serum higher than controls. is increase production acts CTGF, ET-1, β-catenin protect cell function. EC secreted out into blood, circulates through blood liver, continues exert biological effects after being absorbed hepatocytes. LNA-miR-92a administration damage caused affecting KLF2/miR-483 pathway.
Язык: Английский
Процитировано
0