Clinical and Translational Discovery,
Год журнала:
2022,
Номер
2(3)
Опубликована: Сен. 1, 2022
Abstract
Infectious
diseases
remain
a
major
burden
on
global
public
health
and
socio‐economic
stability.
Despite
that
great
progress
has
been
made
in
the
development
of
drugs,
resulting
drug
resistance
remains
problem.
Patients
with
no
response
or
recurrence
need
alternative
treatment
strategies.
The
chimeric
antigen
receptor
(CAR)
therapy
achieves
success
treating
cancer
provides
new
opportunities
for
infectious
diseases.
It
series
advantages
targeting,
efficacy,
durability.
In
this
review,
we
discussed
different
CAR
strategies
diseases,
including
human
immunodeficiency
virus,
viral
hepatitis,
cytomegalovirus,
severe
acute
respiratory
syndrome
coronavirus
2,
influenza
A
virus
Aspergillus
germlings.
Among
all
these
HIV
most
studied,
so
mainly
reported
recent
developments
preclinical
clinical
studies
anti‐HIV
CARs
highlighted
their
structural
evolution.
current
advantages,
challenges
potential
improvements
were
as
well.
We
also
compared
CAR‐T
cells
applied
to
tumours
final
part.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9987 - 9987
Опубликована: Сен. 16, 2024
Host
restriction
factor
GBP2
suppresses
the
replication
of
ecotropic
Moloney
murine
leukemia
virus
(E-MLV)
by
inhibiting
furin
protease,
which
cleaves
viral
envelope
glycoprotein
(Env)
into
surface
(SU)
and
transmembrane
(TM)
subunits.
We
analyzed
impacts
on
infection
efficiency
mediated
MLV
Envs
different
strains
Moloney,
polytropic
Friend,
amphotropic,
xenotropic
MLV-related
(XMRV)
viruses.
Interestingly,
Friend
were
sensitive
to
antiviral
activity
GBP2,
while
XMRV
amphotropic
showed
resistance.
Consistent
with
sensitivity
amino
acid
sequences
at
SU-TM
cleavage
site
similar,
as
resistant
Envs.
GBP2-sensitive
Env
protein
was
inhibited
silencing,
whereas
that
GBP2-resistant
not.
The
substitution
sequence
conferred
resistance
both
silencing.
Reciprocally,
According
sequence,
there
variants
among
ecotropic,
polytropic,
MLVs.
This
study
found
dependence
proteins
GBP2-mediated
is
determined
site.
Abstract
Ranaviruses
(RV,
family
Iridoviridae
)
infect
fish,
amphibians,
and
reptiles,
raising
considerable
ecological
commercial
concerns
due
to
the
escalating
infection
prevalence
resulting
die-offs
of
wild
aquacultural
species.
Notably,
ranaviruses
exhibit
uncanny
capacities
cross
host
species
barriers,
likely
owing
their
potent
immune
evasion
mechanisms.
In
turn,
infected
by
these
pathogens
possess
systems
that
are
less
well
understood
than
those
mammals
often
encode
unique
antiviral
genes
or
multiple
orthologs
single
hallmark
mammalian
factors.
Thus,
garnering
insight
into
ranavirus
strategies
is
largely
contingent
on
gaining
greater
understanding
barriers
faced
emerging
infectious
agents.
Accordingly,
here
we
coalesce
update
current
state
distinct
facets
ectothermic
vertebrate
responses
ranaviral
infections
underline
most
perspectives
which
circumvent
defenses.
Virus Research,
Год журнала:
2024,
Номер
350, С. 199506 - 199506
Опубликована: Дек. 1, 2024
CCR5
is
the
main
co-receptor
for
HIV-1
cell
entry
and
it
plays
key
roles
in
mucosal
transmission.
Natural
anti-CCR5
antibodies
were
found
HIV-1-exposed
seronegative
long-term
non-progressor
subjects,
suggesting
a
role
controlling
viral
replication
vivo.
We
assessed
effect
of
sera
containing
or
not
natural
antibodies,
on
membrane
level
infection
primary
macrophages.
Sera
modulated
expression
with
trend
dependent
donor/serum
tested
but
independent
presence
absence
antibodies.
All
strongly
reduced
DNA
all
donor's
macrophages
no
correlation
was
observed
between
levels.
These
results
suggest
that
major
determinant
macrophage
modulation
might
depend
factors
other
than
CCR5-reactive
present
and/or
intrinsic
to
donors
which
tested.
Viruses,
Год журнала:
2024,
Номер
16(8), С. 1176 - 1176
Опубликована: Июль 23, 2024
The
different
susceptibility
to
HIV-1
infection
in
U937
cells-permissive
(Plus)
or
nonpermissive
(Minus)-is
linked
the
expression
Minus
cells
of
interferon
(IFN)-γ
inducible
antiviral
factors
such
as
tripartite
motif-containing
protein
22
(TRIM22)
and
class
II
transactivator
(CIITA).
CIITA
interacts
with
Cyclin
T1,
a
key
component
Positive-Transcription
Elongation
Factor
b
(P-TEFb)
complex
needed
for
efficient
transcription
upon
interaction
viral
Tat.
TRIM22
CIITA,
recruiting
it
into
nuclear
bodies
together
T1.
A
50
kDa
T1
was
found
only
cells,
alongside
canonical
80
protein.
this
truncated
form
remained
unaffected
by
proteasome
inhibitors
but
reduced
IFNγ
treatment.
Unlike
full-length
protein,
also
present
cytoplasm,
subcellular
localization
correlated
its
capacity
inhibit
Tat-mediated
transcription.
likely
contributes
their
non-permissive
phenotype
acting
dominant
negative
factor,
disrupting
P-TEFb
formation
function.
Its
reduction
treatment
suggests
regulatory
loop
which
inhibitory
role
on
replication
is
then
exerted
IFNγ-induced
binds
displacing
from
complex.
Clinical and Translational Discovery,
Год журнала:
2022,
Номер
2(3)
Опубликована: Сен. 1, 2022
Abstract
Infectious
diseases
remain
a
major
burden
on
global
public
health
and
socio‐economic
stability.
Despite
that
great
progress
has
been
made
in
the
development
of
drugs,
resulting
drug
resistance
remains
problem.
Patients
with
no
response
or
recurrence
need
alternative
treatment
strategies.
The
chimeric
antigen
receptor
(CAR)
therapy
achieves
success
treating
cancer
provides
new
opportunities
for
infectious
diseases.
It
series
advantages
targeting,
efficacy,
durability.
In
this
review,
we
discussed
different
CAR
strategies
diseases,
including
human
immunodeficiency
virus,
viral
hepatitis,
cytomegalovirus,
severe
acute
respiratory
syndrome
coronavirus
2,
influenza
A
virus
Aspergillus
germlings.
Among
all
these
HIV
most
studied,
so
mainly
reported
recent
developments
preclinical
clinical
studies
anti‐HIV
CARs
highlighted
their
structural
evolution.
current
advantages,
challenges
potential
improvements
were
as
well.
We
also
compared
CAR‐T
cells
applied
to
tumours
final
part.
