Chimeric antigen receptor engineered cells and their clinical application in infectious disease DOI Creative Commons
Qian Chen, Xiaochen Bo, Jiaqi Hao

et al.

Clinical and Translational Discovery, Journal Year: 2022, Volume and Issue: 2(3)

Published: Sept. 1, 2022

Abstract Infectious diseases remain a major burden on global public health and socio‐economic stability. Despite that great progress has been made in the development of drugs, resulting drug resistance remains problem. Patients with no response or recurrence need alternative treatment strategies. The chimeric antigen receptor (CAR) therapy achieves success treating cancer provides new opportunities for infectious diseases. It series advantages targeting, efficacy, durability. In this review, we discussed different CAR strategies diseases, including human immunodeficiency virus, viral hepatitis, cytomegalovirus, severe acute respiratory syndrome coronavirus 2, influenza A virus Aspergillus germlings. Among all these HIV most studied, so mainly reported recent developments preclinical clinical studies anti‐HIV CARs highlighted their structural evolution. current advantages, challenges potential improvements were as well. We also compared CAR‐T cells applied to tumours final part.

Language: Английский

The protective effects of apelin-13 in HIV-1 tat- induced macrophage infiltration and BBB impairment DOI
Qi Cao,

Zeng Wei,

Jingmin Nie

et al.

Tissue Barriers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Impairment of the blood - brain barrier (BBB) and subsequent inflammatory responses contribute to development human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND). Apelin-13, most abundant member apelin family, acts as ligand angiotensin receptor-like 1 (APJ). However, its pharmacological function in HAND underlying mechanism are unknown. In current study, we report that presence HIV-1 Tat reduced levels Apelin-13 APJ cortex tissue mice. Importantly, preserved BBB integrity against mice by increasing expression tight junction protein zonula occludens-1 (ZO-1) occludin. Interestingly, increased macrophage infiltration, indicated elevated CD68-positive staining was observed after stimulation with HIV-1, which mitigated administration Apelin-13. Correspondingly, monocyte chemoattractant protein-1; (MCP-1). An

Language: Английский

Citations

0
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site DOI Open Access
Yoshinao Kubo, Manya Bakatumana Hans,

Taisuke Nakamura

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9987 - 9987

Published: Sept. 16, 2024

Host restriction factor GBP2 suppresses the replication of ecotropic Moloney murine leukemia virus (E-MLV) by inhibiting furin protease, which cleaves viral envelope glycoprotein (Env) into surface (SU) and transmembrane (TM) subunits. We analyzed impacts on infection efficiency mediated MLV Envs different strains Moloney, polytropic Friend, amphotropic, xenotropic MLV-related (XMRV) viruses. Interestingly, Friend were sensitive to antiviral activity GBP2, while XMRV amphotropic showed resistance. Consistent with sensitivity amino acid sequences at SU-TM cleavage site similar, as resistant Envs. GBP2-sensitive Env protein was inhibited silencing, whereas that GBP2-resistant not. The substitution sequence conferred resistance both silencing. Reciprocally, According sequence, there variants among ecotropic, polytropic, MLVs. This study found dependence proteins GBP2-mediated is determined site.

Language: Английский

Citations

0
Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5 DOI Creative Commons
Iole Farina, Mauro Andreotti, Claudia Pastori

et al.

Virus Research, Journal Year: 2024, Volume and Issue: 350, P. 199506 - 199506

Published: Dec. 1, 2024

CCR5 is the main co-receptor for HIV-1 cell entry and it plays key roles in mucosal transmission. Natural anti-CCR5 antibodies were found HIV-1-exposed seronegative long-term non-progressor subjects, suggesting a role controlling viral replication vivo. We assessed effect of sera containing or not natural antibodies, on membrane level infection primary macrophages. Sera modulated expression with trend dependent donor/serum tested but independent presence absence antibodies. All strongly reduced DNA all donor's macrophages no correlation was observed between levels. These results suggest that major determinant macrophage modulation might depend factors other than CCR5-reactive present and/or intrinsic to donors which tested.

Language: Английский

Citations

0
Immune Defenses Against Ranavirus Infections DOI Creative Commons
Leon Grayfer,

Eva‐Stina Edholm,

V. Gregory Chinchar

et al.

Published: Oct. 11, 2024

Abstract Ranaviruses (RV, family Iridoviridae ) infect fish, amphibians, and reptiles, raising considerable ecological commercial concerns due to the escalating infection prevalence resulting die-offs of wild aquacultural species. Notably, ranaviruses exhibit uncanny capacities cross host species barriers, likely owing their potent immune evasion mechanisms. In turn, infected by these pathogens possess systems that are less well understood than those mammals often encode unique antiviral genes or multiple orthologs single hallmark mammalian factors. Thus, garnering insight into ranavirus strategies is largely contingent on gaining greater understanding barriers faced emerging infectious agents. Accordingly, here we coalesce update current state distinct facets ectothermic vertebrate responses ranaviral infections underline most perspectives which circumvent defenses.

Language: Английский

Citations

0
Zipper interacting protein kinase (ZIPK) is a negative regulator of HIV-1 replication that is restricted by viral Nef protein through proteasomal degradation DOI
Muneesh Kumar Barman,

Kailash Chand,

Debashis Mitra

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 625, P. 122 - 127

Published: Aug. 3, 2022

Language: Английский

Citations

1
The APOBEC3G gene rs2294367(C>G) variant is associated with HIV-1 infection in Moroccan subjects DOI
Imane Belbacha, Meryem El Azzouzi,

Rajae Bensghir

et al.

Acta Tropica, Journal Year: 2023, Volume and Issue: 249, P. 107045 - 107045

Published: Oct. 30, 2023

Language: Английский

Citations

0
Chimeric antigen receptor engineered cells and their clinical application in infectious disease DOI Creative Commons
Qian Chen, Xiaochen Bo, Jiaqi Hao

et al.

Clinical and Translational Discovery, Journal Year: 2022, Volume and Issue: 2(3)

Published: Sept. 1, 2022

Abstract Infectious diseases remain a major burden on global public health and socio‐economic stability. Despite that great progress has been made in the development of drugs, resulting drug resistance remains problem. Patients with no response or recurrence need alternative treatment strategies. The chimeric antigen receptor (CAR) therapy achieves success treating cancer provides new opportunities for infectious diseases. It series advantages targeting, efficacy, durability. In this review, we discussed different CAR strategies diseases, including human immunodeficiency virus, viral hepatitis, cytomegalovirus, severe acute respiratory syndrome coronavirus 2, influenza A virus Aspergillus germlings. Among all these HIV most studied, so mainly reported recent developments preclinical clinical studies anti‐HIV CARs highlighted their structural evolution. current advantages, challenges potential improvements were as well. We also compared CAR‐T cells applied to tumours final part.

Language: Английский

Citations

0