Association between COVID-19 and the development of chronic kidney disease in patients without initial acute kidney injury

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 29, 2025

Язык: Английский

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Monkeypox has devastated the world; should we prepare for the outbreak of a new pandemic?

Annals of Medicine and Surgery, Год журнала: 2022, Номер 79

Опубликована: Июнь 23, 2022

The monkeypox virus, which belongs to the orthopoxy virus family, causes fever, lethargy, headache, lymphadenopathy, myalgia, and rash, as well various complications such superimposed infections, sepsis, keratitis, encephalitis, bronchopneumonia. Following replication at site of injection, often enters by oropharynx, nasopharynx, or intradermal pathway, spreading lymph nodes before viremia, promoting viral dissemination other organ systems. Monkeypox cases have recently been brought WHO's notice from 12 presently non-endemic member nations spread over three WHO regions, with 92 laboratory-confirmed 28 suspicion May 21, 2022. is endemic in Central African Republic, Democratic Republic Congo, Benin, Cameroon, Gabon, Sierra Leone, South Sudan. detected all across world, posing a challenge healthcare infrastructure that still recovering COVID-19 outbreak. Close monitoring exact data collecting, implementation successful programs public support preventative measures are some strategies being used cope increasing incidence monkeypox.

Язык: Английский

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Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review

Biomedicines, Год журнала: 2025, Номер 13(2), С. 407 - 407

Опубликована: Фев. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Язык: Английский

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An Anisole Derivative in the Essential oil of Wurfbainia schmidtii with Virucidal Activity Against SARS-CoV-2 and Anti-Inflammatory Properties

Natural Product Communications, Год журнала: 2025, Номер 20(3)

Опубликована: Март 1, 2025

Objectives: Essential oils from many plants have been reported to anti-inflammatory activity. However, essential oil of Wurfbainia schmidtii leaves has never for Moreover, previous works on the compositions W. (synonyms Amomum biflorum and ) varied in its oils. This work aims at investigating activity, as well virucidal activity against SARS-CoV-2 virus. Methods: The composition was analyzed by gas chromatography-mass spectrometry (GC-MS) technique. A crude hexane extract separated chromatographic method, giving a major phenylbutanoid, trans - p -(l-butenyl)-anisole ( 1 ), whose structure elucidated analysis 1D 2D H nuclear magnetic resonance (NMR) spectra. Anti-inflammatory compound evaluated, virus assessed . Results: component found be accounting 88.69%, it exhibited with EC 50 value 119.60 μM. IC values 0.0282 mg/mL 12.74 μM, respectively. Conclusion: -(l-Butenyl)-anisole , displayed activities. showed

Язык: Английский

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The sperm quality change in 6 months recovery from COVID-19 : a retrospective observational study

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

XZ and YZ performed the data analyses drafted manuscript. NJ, KL JX participated in collection. design of study coordination. ZL TX had main responsibility for design, analyses, interpretation, writing All authors read approved final Background The COVID-19 pandemic has yielded substantial evidence indicating that virus may possess reproductive toxicity effects adversely affect sperm quality. Given sex-specific implications these findings, it is imperative to reliably assess reversibility this damage, determine precise recovery time, evaluate male health parameters post-infection. Methods Male patients who underwent analysis prior infection were enrolled a observational trial changes quality during 6-month period from COVID-19. Sperm dynamic collected at five consecutive time points: before 1, 2, 3, 6 months following infection. Quality life, psychological status, sexual function patients, evaluated with questionnaires, first month after primary outcomes concentration (Con) progressive motility rate (PR%). Generalized Estimating Equations (GEEs) was used perform statistical comparisons on repeatedly measured variables. Kaplan-Meier survival employed observe trend over time. Results 1,009 subjects widespread COVID-19, April 2022 January 2023. Of 139 eligible have completed infection, 92 (66%) testing second month, 72 (52%) third 64 (46%) sixth month. Con [39·22 (95%CI, 32·02–46·41)] PR [36·41 3229-40·53)] significantly decreased post-infection compared pre-infection. demonstrated gradual At end our six-month observation period, continue be lower than levels observed Survival curve indicated that, average, duration 4·37 required achieve an 80% level During no significant adverse impacts participants' diverse scores. Discussion indeed influenced by but temporary, 4–5 months. Furthermore, notable alterations men's psychological, urinary symptoms, or initial

Язык: Английский

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SARS-CoV-2 infection and complicated appendicitis in adults in Lima, Peru: a matched case-control study

BMC Surgery, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 16, 2025

Язык: Английский

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Differentially‐regulated miRNAs in COVID‐19: A systematic review

Reviews in Medical Virology, Год журнала: 2023, Номер 33(4)

Опубликована: Май 5, 2023

Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is responsible for coronavirus disease of 2019 (COVID‐19) that infected more than 760 million people worldwide with over 6.8 deaths to date. COVID‐19 one the most challenging diseases our times due nature its spread, effect on multiple organs, and an inability predict prognosis, ranging from being completely asymptomatic death. Upon infection, SARS‐CoV‐2 alters host immune response by changing host‐transcriptional machinery. MicroRNAs (miRNAs) are regarded as post‐transcriptional regulators gene expression can be perturbed invading viruses. Several in vitro vivo studies have reported such dysregulation miRNA upon infection. Some this could occur anti‐viral viral Viruses themselves counteract mounting their own pro‐viral facilitates virus aspect which may cause pathogenesis. Thus, miRNAs serve possible biomarkers people. In current review, we summarised analysed existing data about patients determine concordance between studies, identified those potential during progression, death, even other co‐morbidities. Having vital not only predicting but also development novel miRNA‐based anti‐virals therapeutics become invaluable case emergence new variants pandemic future.

Язык: Английский

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A tiny viral protein, SARS-CoV-2-ORF7b: Functional molecular mechanisms.

Опубликована: Март 8, 2024

This study presents the interaction with human host metabolism of SARS-CoV-2 ORF7b protein (43 aa), using a Protein-Protein-Interaction Networks analysis. After pruning, we selected from BioGRID 51 most significant proteins among 2,753 proven interactions and 1,708 interactors, specific to ORF7b. We used these as functional seeds got network 551 nodes via STRING. performed topological analysis calculated distributions by Cytoscape. Seven high ranked hub seven bottleneck following hub-and-spoke network-architectural-model were found. Through this model, identified GO-processes (5,057 terms in 15 categories) induced High statistical significance processes dysregulated molecular cell mechanisms action discovered. detected disease-related their involvement metabolic roles, how they relate distorted way signaling and/or systems, particular intra- inter-cellular systems that supervise programmed death, similar cancer metastasis diffusion. A cluster showed 10 compact clusters, where two them overlap Giant-Connected-Components core 206 total nodes. These clusters contain high-rank mainly acts through inducing dysregulation. conducted co-regulation, transcriptional proteins. allowed us define transcription factors miRNAs control high-ranking processes, within limits poor knowledge sectors still impose.

Язык: Английский

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Persistence of SARS-CoV-2 Antigens in the Nasal Mucosa of Eight Patients with Inflammatory Rhinopathy for over 80 Days following Mild COVID-19 Diagnosis

Viruses, Год журнала: 2023, Номер 15(4), С. 899 - 899

Опубликована: Март 31, 2023

The nasal mucosa is the main gateway for entry, replication and elimination of SARS-CoV-2 virus, pathogen that causes severe acute respiratory syndrome (COVID-19). presence virus in epithelium damage to compromises mucociliary clearance. aim this study was investigate viral antigens patients with a history mild COVID-19 persistent inflammatory rhinopathy. We evaluated eight adults without previous diseases olfactory dysfunction more than 80 days after diagnosis infection. Samples were collected via brushing middle concha. detection performed using immunofluorescence through confocal microscopy. Viral detected all patients. Persistent anosmia observed four Our findings suggest may lead rhinopathy prolonged or relapsing anosmia. This sheds light on potential mechanisms underlying symptoms highlights importance monitoring nasal-related symptoms.

Язык: Английский

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COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2212 - 2212

Опубликована: Фев. 12, 2024

The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related diverse extrapulmonary manifestations this pathology. liver was found be a relatively common organ, beyond the respiratory tract, affected by severe acute syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed essential role chronic (CLD) in general outcome infection. Present concerns field are direct hepatic caused COVID-19 and pre-existing disorders as risk factors for course Which mechanism has key phenomenon—previously existing disorder or failure SARS-CoV-2—is still not fully clarified. Alcoholic (ALD) constitutes another elucidated context Should toxic effects ethanol already developed cirrhosis its perceived causative triggering factor impairment patients? In face these discrepancies, we decided summarize whole picture infection, paying special attention ALD focusing on pathological pathways COVID-19, toxicity cirrhosis.

Язык: Английский

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