Association between COVID-19 and the development of chronic kidney disease in patients without initial acute kidney injury

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 29, 2025

Language: Английский

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Monkeypox has devastated the world; should we prepare for the outbreak of a new pandemic?

Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 79

Published: June 23, 2022

The monkeypox virus, which belongs to the orthopoxy virus family, causes fever, lethargy, headache, lymphadenopathy, myalgia, and rash, as well various complications such superimposed infections, sepsis, keratitis, encephalitis, bronchopneumonia. Following replication at site of injection, often enters by oropharynx, nasopharynx, or intradermal pathway, spreading lymph nodes before viremia, promoting viral dissemination other organ systems. Monkeypox cases have recently been brought WHO's notice from 12 presently non-endemic member nations spread over three WHO regions, with 92 laboratory-confirmed 28 suspicion May 21, 2022. is endemic in Central African Republic, Democratic Republic Congo, Benin, Cameroon, Gabon, Sierra Leone, South Sudan. detected all across world, posing a challenge healthcare infrastructure that still recovering COVID-19 outbreak. Close monitoring exact data collecting, implementation successful programs public support preventative measures are some strategies being used cope increasing incidence monkeypox.

Language: Английский

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Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 407 - 407

Published: Feb. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Language: Английский

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An Anisole Derivative in the Essential oil of Wurfbainia schmidtii with Virucidal Activity Against SARS-CoV-2 and Anti-Inflammatory Properties

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(3)

Published: March 1, 2025

Objectives: Essential oils from many plants have been reported to anti-inflammatory activity. However, essential oil of Wurfbainia schmidtii leaves has never for Moreover, previous works on the compositions W. (synonyms Amomum biflorum and ) varied in its oils. This work aims at investigating activity, as well virucidal activity against SARS-CoV-2 virus. Methods: The composition was analyzed by gas chromatography-mass spectrometry (GC-MS) technique. A crude hexane extract separated chromatographic method, giving a major phenylbutanoid, trans - p -(l-butenyl)-anisole ( 1 ), whose structure elucidated analysis 1D 2D H nuclear magnetic resonance (NMR) spectra. Anti-inflammatory compound evaluated, virus assessed . Results: component found be accounting 88.69%, it exhibited with EC 50 value 119.60 μM. IC values 0.0282 mg/mL 12.74 μM, respectively. Conclusion: -(l-Butenyl)-anisole , displayed activities. showed

Language: Английский

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The sperm quality change in 6 months recovery from COVID-19 : a retrospective observational study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

XZ and YZ performed the data analyses drafted manuscript. NJ, KL JX participated in collection. design of study coordination. ZL TX had main responsibility for design, analyses, interpretation, writing All authors read approved final Background The COVID-19 pandemic has yielded substantial evidence indicating that virus may possess reproductive toxicity effects adversely affect sperm quality. Given sex-specific implications these findings, it is imperative to reliably assess reversibility this damage, determine precise recovery time, evaluate male health parameters post-infection. Methods Male patients who underwent analysis prior infection were enrolled a observational trial changes quality during 6-month period from COVID-19. Sperm dynamic collected at five consecutive time points: before 1, 2, 3, 6 months following infection. Quality life, psychological status, sexual function patients, evaluated with questionnaires, first month after primary outcomes concentration (Con) progressive motility rate (PR%). Generalized Estimating Equations (GEEs) was used perform statistical comparisons on repeatedly measured variables. Kaplan-Meier survival employed observe trend over time. Results 1,009 subjects widespread COVID-19, April 2022 January 2023. Of 139 eligible have completed infection, 92 (66%) testing second month, 72 (52%) third 64 (46%) sixth month. Con [39·22 (95%CI, 32·02–46·41)] PR [36·41 3229-40·53)] significantly decreased post-infection compared pre-infection. demonstrated gradual At end our six-month observation period, continue be lower than levels observed Survival curve indicated that, average, duration 4·37 required achieve an 80% level During no significant adverse impacts participants' diverse scores. Discussion indeed influenced by but temporary, 4–5 months. Furthermore, notable alterations men's psychological, urinary symptoms, or initial

Language: Английский

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SARS-CoV-2 infection and complicated appendicitis in adults in Lima, Peru: a matched case-control study

BMC Surgery, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 16, 2025

Language: Английский

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Microbiome dysbiosis in SARS-CoV-2 infection: implication for pathophysiology and management strategies of COVID-19

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 22, 2025

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent disease 2019 (COVID-19), in late initiated a global health crisis marked by widespread infection, significant mortality, and long-term implications. While SARS-CoV-2 primarily targets system, recent findings indicate that it also significantly disrupts human microbiome, particularly gut microbiota, contributing to severity, systemic inflammation, immune dysregulation, increased susceptibility secondary infections chronic conditions. Dysbiosis, or microbial imbalance, exacerbates clinical outcomes COVID-19 has been linked long-COVID, condition affecting proportion survivors manifesting with over 200 symptoms across multiple organ systems. Despite growing recognition microbiome alterations COVID-19, precise mechanisms which interacts influences progression remain poorly understood. This narrative review investigates impact on host-microbiota dynamics evaluates its implications severity for developing personalized therapeutic strategies COVID-19. Furthermore, highlights dual role modulating progression, as promising target advancing diagnostic, prognostic, approaches managing

Language: Английский

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The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: May 17, 2025

Language: Английский

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Differentially‐regulated miRNAs in COVID‐19: A systematic review

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 33(4)

Published: May 5, 2023

Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is responsible for coronavirus disease of 2019 (COVID‐19) that infected more than 760 million people worldwide with over 6.8 deaths to date. COVID‐19 one the most challenging diseases our times due nature its spread, effect on multiple organs, and an inability predict prognosis, ranging from being completely asymptomatic death. Upon infection, SARS‐CoV‐2 alters host immune response by changing host‐transcriptional machinery. MicroRNAs (miRNAs) are regarded as post‐transcriptional regulators gene expression can be perturbed invading viruses. Several in vitro vivo studies have reported such dysregulation miRNA upon infection. Some this could occur anti‐viral viral Viruses themselves counteract mounting their own pro‐viral facilitates virus aspect which may cause pathogenesis. Thus, miRNAs serve possible biomarkers people. In current review, we summarised analysed existing data about patients determine concordance between studies, identified those potential during progression, death, even other co‐morbidities. Having vital not only predicting but also development novel miRNA‐based anti‐virals therapeutics become invaluable case emergence new variants pandemic future.

Language: Английский

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A tiny viral protein, SARS-CoV-2-ORF7b: Functional molecular mechanisms.

Published: March 8, 2024

This study presents the interaction with human host metabolism of SARS-CoV-2 ORF7b protein (43 aa), using a Protein-Protein-Interaction Networks analysis. After pruning, we selected from BioGRID 51 most significant proteins among 2,753 proven interactions and 1,708 interactors, specific to ORF7b. We used these as functional seeds got network 551 nodes via STRING. performed topological analysis calculated distributions by Cytoscape. Seven high ranked hub seven bottleneck following hub-and-spoke network-architectural-model were found. Through this model, identified GO-processes (5,057 terms in 15 categories) induced High statistical significance processes dysregulated molecular cell mechanisms action discovered. detected disease-related their involvement metabolic roles, how they relate distorted way signaling and/or systems, particular intra- inter-cellular systems that supervise programmed death, similar cancer metastasis diffusion. A cluster showed 10 compact clusters, where two them overlap Giant-Connected-Components core 206 total nodes. These clusters contain high-rank mainly acts through inducing dysregulation. conducted co-regulation, transcriptional proteins. allowed us define transcription factors miRNAs control high-ranking processes, within limits poor knowledge sectors still impose.

Language: Английский

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