Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 11, 2024
Abstract
Huntington’s
disease
(HD)
is
a
neurological
disorder
caused
by
CAG
expansion
in
the
Huntingtin
gene
(
HTT
).
HD
pathology
mostly
affects
striatal
medium-sized
spiny
neurons
and
results
an
altered
cortico-striatal
function.
Recent
studies
report
that
motor
skill
learning,
stimulation
attenuate
neuropathology
HD,
resulting
amelioration
of
some
cognitive
functions.
During
physical
training,
extracellular
vesicles
(EVs)
are
released
many
tissues,
including
brain,
as
potential
means
for
inter-tissue
communication.
To
investigate
how
involving
acute
modulates
EVs
crosstalk
between
cells
striatum,
we
trained
wild-type
(WT)
R6/1
mice,
latter
with
deficits,
on
accelerating
rotarod
test,
isolated
their
EVs.
from
mice
presented
alterations
small
exosome
population
when
compared
to
WT.
Proteomic
analyses
revealed
recapitulated
signaling
energy
deficiencies
present
HD.
Motor
learning
restored
amount
protein
content
comparison
naïve
mice.
Furthermore,
modulated
crucial
pathways
metabolism
neurodegeneration.
All
these
data
provide
new
insights
into
pathogenesis
put
spotlight
understand
metabolic
neurodegenerative
diseases.
Moreover,
our
suggest
modulator
cell-to-cell
communication
striatum.
Translational Neurodegeneration,
Год журнала:
2022,
Номер
11(1)
Опубликована: Дек. 12, 2022
Abstract
Extracellular
vesicles
(EVs)
are
small
bilipid
layer-enclosed
that
can
be
secreted
by
all
tested
types
of
brain
cells.
Being
a
key
intercellular
communicator,
EVs
have
emerged
as
contributor
to
the
pathogenesis
various
neurodegenerative
diseases
(NDs)
including
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis,
and
Huntington’s
disease
through
delivery
bioactive
cargos
within
central
nervous
system
(CNS).
Importantly,
CNS
cell-derived
purified
via
immunoprecipitation,
EV
with
altered
levels
been
identified
potential
biomarkers
for
diagnosis
prognosis
NDs.
Given
essential
impact
on
NDs,
pathological
considered
therapeutic
targets
effects
utilized
agents
or
drug
platforms
treatment
In
this
review,
we
focus
recent
research
progress
roles
released
from
cells
in
summarize
findings
identify
CNS-derived
diagnose
comprehensively
discuss
promising
targets,
agents,
systems
treating
together
current
concerns
challenges
basic
clinical
applications
regarding
Exosomes
are
extracellular
vesicles
with
diameters
of
about
100
nm
that
naturally
secreted
by
cells
into
body
fluids.
They
derived
from
endosomes
and
wrapped
in
lipid
membranes.
involved
intracellular
metabolism
intercellular
communication.
contain
nucleic
acids,
proteins,
lipids,
metabolites
the
cell
microenvironment
cytoplasm.
The
contents
exosomes
can
reflect
their
cells'
origin
allow
observation
tissue
changes
states
under
disease
conditions.
Naturally
have
specific
biomolecules
act
as
"fingerprint"
parent
cells,
changed
pathological
conditions
be
used
biomarkers
for
diagnosis.
low
immunogenicity,
small
size,
cross
blood-brain
barrier.
These
characteristics
make
unique
engineering
carriers.
incorporate
therapeutic
drugs
achieve
targeted
drug
delivery.
carriers
therapy
still
infancy,
but
exosome
provides
a
new
perspective
cell-free
therapy.
This
review
discussed
relationship
occurrence
treatment
some
neuropsychiatric
diseases.
In
addition,
future
applications
diagnosis
disorders
were
evaluated
this
review.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
379(1899)
Опубликована: Фев. 19, 2024
Over
the
past
two
decades,
increased
research
has
highlighted
connection
between
endosomal
trafficking
defects
and
neurodegeneration.
The
endo-lysosomal
network
is
an
important,
complex
cellular
system
specialized
in
transport
of
proteins,
lipids,
other
metabolites,
essential
for
cell
homeostasis.
Disruption
this
pathway
linked
to
a
wide
range
neurodegenerative
diseases,
including
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis,
Huntington's
disease
frontotemporal
dementia.
Furthermore,
there
strong
evidence
that
create
opportunities
diagnostic
therapeutic
intervention.
In
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6051 - 6051
Опубликована: Март 23, 2023
Huntington's
disease
(HD)
is
characterized
by
clinical
motor
impairment
(e.g.,
involuntary
movements,
poor
coordination,
parkinsonism),
cognitive
deficits,
and
psychiatric
symptoms.
An
inhered
expansion
of
the
CAG
triplet
in
huntingtin
gene
causing
a
pathogenic
gain-of-function
mutant
(mHTT)
protein
has
been
identified.
In
this
review,
we
focus
on
known
biomarkers
mHTT,
neurofilament
light
chains)
new
biofluid
that
can
be
quantified
plasma
or
peripheral
blood
mononuclear
cells
from
mHTT
carriers.
Circulating
may
fill
current
unmet
needs
HD
management:
better
stratification
patients
amenable
to
etiologic
treatment;
initiation
preventive
treatment
premanifest
HD;
identification
central
nervous
system
cascades.
Translational Neurodegeneration,
Год журнала:
2022,
Номер
11(1)
Опубликована: Ноя. 27, 2022
Abstract
Neurodegenerative
disorders
are
one
of
the
most
common
causes
disability
and
represent
6.3%
global
burden
disease.
Among
them,
Alzheimer’s,
Parkinson’s,
Huntington’s
diseases
cause
cognitive
decline,
representing
disabling
symptom
on
both
personal
social
levels.
The
molecular
mechanisms
underlying
onset
progression
dementia
still
poorly
understood,
include
secretory
factors
potentially
affecting
differentiated
neurons,
glial
cells
neural
stem
cell
niche.
In
last
decade,
much
attention
has
been
devoted
to
exosomes
as
novel
carriers
information
exchanged
among
neighbouring
distant
cells.
These
vesicles
can
be
generated
internalized
by
different
brain
including
cells,
astrocytes,
microglia,
thereby
plasticity
functions
in
physiological
pathological
conditions.
Here,
we
review
data
roles
bioactive
molecules
involved
pathogenesis
neurodegenerative
detectable
biological
fluids
biomarkers
dementia.
We
also
discuss
experimental
evidence
therapeutic
potential
cell-derived
models
neurodegeneration-dependent
decline.
Biomolecules,
Год журнала:
2023,
Номер
13(8), С. 1250 - 1250
Опубликована: Авг. 16, 2023
Mesenchymal
stem
cells
(MSCs)
are
a
type
of
versatile
adult
present
in
various
organs.
These
give
rise
to
extracellular
vesicles
(EVs)
containing
diverse
array
biologically
active
elements,
making
them
promising
approach
for
therapeutics
and
diagnostics.
This
article
examines
the
potential
therapeutic
applications
MSC-derived
EVs
addressing
neurodegenerative
disorders
such
as
Alzheimer’s
disease
(AD),
multiple
sclerosis
(MS),
Parkinson’s
(PD),
amyotrophic
lateral
(ALS),
Huntington’s
(HD).
Furthermore,
state-of-the-art
MSC-EV-based
therapy
AD,
HD,
PD,
ALS,
MS
is
discussed.
Significant
progress
has
been
made
understanding
etiology
treatments
range
diseases
(NDs)
over
last
few
decades.
The
contents
carried
across
intercellular
contact,
which
often
results
control
recipient
cell’s
homeostasis.
Since
represent
therapeutically
beneficial
cargo
parent
devoid
many
ethical
problems
connected
with
cell-based
treatments,
they
offer
viable
cell-free
alternative
tissue
regeneration
repair.
Developing
innovative
EV-dependent
medicines
proven
difficult
due
lack
standardized
procedures
EV
extraction
processes
well
their
pharmacological
characteristics
mechanisms
action.
However,
recent
biotechnology
engineering
research
greatly
enhanced
content
applicability
MSC-EVs.
Cells,
Год журнала:
2024,
Номер
13(8), С. 670 - 670
Опубликована: Апрель 12, 2024
Neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
Huntington’s
(HD),
stroke,
and
aneurysms,
are
characterized
by
the
abnormal
accumulation
aggregation
of
disease-causing
proteins
in
brain
spinal
cord.
Recent
research
suggests
that
linked
to
these
conditions
can
be
secreted
transferred
among
cells
using
exosomes.
The
transmission
protein
buildup
gradual
degeneration
brains
impacted
individuals
might
supported
Furthermore,
it
has
been
reported
neuroprotective
functions
also
attributed
exosomes
neurodegenerative
diseases.
potential
may
play
a
role
preventing
formation
aggregates
associated
with
disease.
present
review
summarizes
roles
diseases
well
elucidating
their
therapeutic
AD,
PD,
ALS,
HD,
aneurysms.
By
two
aspects
exosomes,
valuable
insights
into
targets
for
treating
provided.
Abstract
Central
Nervous
System
(CNS)
disorders
represent
a
profound
public
health
challenge
that
affects
millions
of
people
around
the
world.
Diseases
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
and
traumatic
brain
injury
(TBI)
exemplify
complexities
diversities
complicate
their
early
detection
development
effective
treatments.
Amid
these
challenges,
emergence
nanotechnology
extracellular
vesicles
(EVs)
signals
new
dawn
for
treating
diagnosing
CNS
ailments.
EVs
are
cellularly
derived
lipid
bilayer
nanosized
particles
pivotal
in
intercellular
communication
within
have
potential
to
revolutionize
targeted
therapeutic
delivery
identification
novel
biomarkers.
Integrating
with
amplifies
diagnostic
capabilities,
opening
avenues
managing
diseases.
This
review
focuses
on
examining
fascinating
interplay
between
theranostics.
Through
highlighting
remarkable
advancements
unique
methodologies,
we
aim
offer
valuable
perspectives
how
approaches
can
bring
about
revolutionary
change
management.
The
objective
is
harness
distinctive
attributes
forge
personalized,
efficient
interventions
disorders,
thereby
providing
beacon
hope
affected
individuals.
In
short,
confluence
heralds
promising
frontier
impactful
treatments
against
diseases,
which
continue
pose
significant
challenges.
By
focusing
personalized
powerful
methods,
might
improve
quality
patients.
