Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota

Nutrients, Год журнала: 2023, Номер 15(1), С. 228 - 228

Опубликована: Янв. 2, 2023

Dyslipidemia is a multifaceted condition with various genetic and environmental factors contributing to its pathogenesis. Further, this represents an important risk factor for related sequalae including cardiovascular diseases (CVD) such as coronary artery disease (CAD) stroke. Emerging evidence has shown that gut microbiota their metabolites can worsen or protect against the development of dyslipidemia. Although there are currently numerous treatment modalities available lifestyle modification pharmacologic interventions, been promising research on dyslipidemia involves benefits modulating in treating alterations lipid metabolism. In review, we examine relationship between dyslipidemia, impact current dietary prebiotics, probiotics, synbiotics transplant therapeutic prevention disease. Overall, understanding mechanisms by which affect progression will help develop more precise targets optimize

Язык: Английский

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Erchen Decoction alleviates obesity-related hepatic steatosis via modulating gut microbiota-drived butyric acid contents and promoting fatty acid β-oxidation

Journal of Ethnopharmacology, Год журнала: 2023, Номер 317, С. 116811 - 116811

Опубликована: Июнь 17, 2023

Язык: Английский

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A High-Fat, High-Cholesterol Diet Promotes Intestinal Inflammation by Exacerbating Gut Microbiome Dysbiosis and Bile Acid Disorders in Cholecystectomy

Nutrients, Год журнала: 2023, Номер 15(17), С. 3829 - 3829

Опубликована: Сен. 1, 2023

Patients with post-cholecystectomy (PC) often experience adverse gastrointestinal conditions, such as PC syndrome, colorectal cancer (CRC), and non-alcoholic fatty liver disease (NAFLD), that accumulate over time. An epidemiological survey further revealed the risk of cholecystectomy is associated high-fat high-cholesterol (HFHC) dietary intake. Mounting evidence suggests disrupted gut microbial homeostasis dysregulated bile acids (BAs) metabolism. However, effect an HFHC diet on complications after has not been elucidated. Here, we aimed to investigate microbiota–BA metabolic axis elucidate association between this alteration development intestinal inflammation. In study, a mice model was established, levels IL-Iβ, TNF-α, IL-6 in colon were increased fed for 6 weeks. Analysis fecal BA metabolism showed altered rhythm by upregulating CPY7A1, CYP8B1, BSEP ileal ASBT mRNA expression levels, resulting levels. addition, feeding caused significant dysbiosis microbiota, which characterized enrichment microbiota involved BAs; abundance pro-inflammatory related metabolite also significantly higher. contrast, major short-chain acid (SCFA)-producing bacteria decreased. Overall, our study promotes inflammation exacerbating microbiome cholecystectomy. Our provides useful insights into maintenance health through or probiotic intervention strategies.

Язык: Английский

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Lactiplantibacillus plantarum ATCC8014 Alleviates Postmenopausal Hypercholesterolemia in Mice by Remodeling Intestinal Microbiota to Increase Secondary Bile Acid Excretion

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(12), С. 6236 - 6249

Опубликована: Март 14, 2024

Hypercholesterolemia poses a significant cardiovascular risk, particularly in postmenopausal women. The anti-hypercholesterolemic properties of Lactiplantibacillus plantarum ATCC8014 (LP) are well recognized; however, its improving symptoms on hypercholesterolemia and the possible mechanisms have yet to be elucidated. Here, we utilized female ApoE-deficient (ApoE–/–) mice undergoing bilateral ovariectomy, fed high-fat diet, administered 109 colony-forming units (CFU) LP for 13 consecutive weeks. intervention reduces total cholesterol (TC) triglyceride (TG) accumulation serum liver accelerates their fecal excretion, which is mainly accomplished by increasing excretion secondary bile acids (BAs), thereby facilitating conversion. Correlation analysis revealed that lithocholic acid (LCA) an important regulator lipid abnormalities. can reduce LCA while enhancing elevating relative abundances Allobaculum Olsenella ileum. Our findings demonstrate dysfunction accompanied abnormalities BA metabolism dysbiosis intestinal microbiota. holds therapeutic potential hypercholesterolemia. Its effectiveness ameliorating dysregulation primarily achieved through reshaping diversity abundance microbiota correct

Язык: Английский

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The bile–gut axis and metabolic consequences of cholecystectomy

European Journal of Endocrinology, Год журнала: 2024, Номер 190(4), С. R1 - R9

Опубликована: Март 28, 2024

Abstract Cholelithiasis and cholecystitis affect individuals of all ages are often treated by surgical removal the gallbladder (cholecystectomy), which is considered a safe, low-risk procedure. Nevertheless, recent findings show that bile its regulated storage excretion may have important metabolic effects cholecystectomy associated with several diseases postoperatively. Bile acids long been known as emulsifiers essential to assimilation lipids absorption lipid-soluble vitamins, but more recently, they also reported act signaling agents. The nuclear receptor, farnesoid X receptor (FXR), G protein–coupled membrane Takeda 5 (TGR5), specific acids. Through activation these receptors, control numerous functions. Cholecystectomy affects acids, in turn influence FXR TGR5 their on metabolism including processes leading conditions such dysfunction–associated steatotic liver disease syndrome. Here, aim elucidating mechanisms behind cholecystectomy-associated dysmetabolism, we review studies potentially linking acid–mediated discuss possible pathophysiological dysmetabolism.

Язык: Английский

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Modulation of the Gut Microbiota in Memory Impairment and Alzheimer’s Disease via the Inhibition of the Parasympathetic Nervous System

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13574 - 13574

Опубликована: Ноя. 5, 2022

The gut microbiota has been demonstrated to play a critical role in maintaining cognitive function via the gut-brain axis, which may be related parasympathetic nervous system (PNS). However, exact mechanism remains determined. We investigated that patients with mild impairment (MCI) and Alzheimer's disease (AD) could exhibit an altered through suppression of PNS, compared healthy individuals, using combined data from previous human studies. hypothesis was validated rats suppress PNS by scopolamine injections. fecal bacterial FASTA/Q files were selected four different AD studies (n = 410). All had high-fat diet treatments for six weeks. MD memory injection (2 mg/kg body weight; MD, Control) or no saline injection. scopolamine-injected donepezil intake as positive group. In optimal model generated XGboost analysis, Blautia luti, Pseudomonas mucidoiens, Escherichia marmotae, Gemmiger formicillis showed correlation MCI while fergusonii, Mycobacterium neglectum, Lawsonibacter asaccharolyticus positively correlated participants enterotype Bacteroides (ET-B, n 369). predominant bacteria group negatively associated networking analysis ET-B participants. From animal study, relative abundance Bilophilia lower, Escherichia, Blautia, Clostridium higher scopolamine-induced deficit (MD) than normal These results suggest progress exacerbating dysbiosis. increased its progression elevated Pseudomonas. Therefore, modulation might linked brain function, potentially axis.

Язык: Английский

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Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2022, Номер 108(2), С. 251 - 270

Опубликована: Ноя. 14, 2022

Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy metabolism and inflammation. Recent epidemiological studies have reported specific alterations in circulating BA profiles certain disease states, including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver (NAFLD), Alzheimer (AD). In the past decade, breakthroughs been made regarding translation of profiling into clinical use for prediction. this review, we summarize synthesize recent data on variation patients with various diseases to evaluate value these biomarkers human plasma early diagnosis. Evidence Acquisition This review is based a collection primary literature gathered from PubMed search BAs, T2DM, insulin resistance (IR), NAFLD, hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), colon cancer, AD, among other keywords. Synthesis Individuals HCC, CCA, or AD showed profiles. These may existed long before initial diagnosis diseases. The intricate relationship between IR, NAFLD complicates establishment clear independent associations steatohepatitis. Alterations levels total BAs several species were seen across entire spectrum demonstrating significant increases worsening histological features. Conclusions Aberrant an event onset progression AD. pleiotropic effects explain broad connections. Circulating could provide basis development prevention wide range

Язык: Английский

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Fecal Microbiota Composition, Their Interactions, and Metagenome Function in US Adults with Type 2 Diabetes According to Enterotypes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9533 - 9533

Опубликована: Май 31, 2023

T2DM etiology differs among Asians and Caucasians may be associated with gut microbiota influenced by different diet patterns. However, the association between fecal bacterial composition, enterotypes, susceptibility remained controversial. We investigated co-abundance network, metagenome function in US adults compared to healthy based on enterotypes. analyzed 1911 files of 1039 872 from Human Microbiome Projects. Operational taxonomic units were obtained after filtering cleaning using Qiime2 tools. Machine learning network analysis identified primary bacteria their interactions influencing incidence, clustered into Bacteroidaceae (ET-B), Lachnospiraceae (ET-L), Prevotellaceae (ET-P). ET-B showed higher incidence. Alpha-diversity was significantly lower ET-L ET-P (p < 0.0001), but not ET-B. Beta-diversity revealed a distinct separation groups across all enterotypes 0.0001). The XGBoost model exhibited high accuracy sensitivity. Enterocloster bolteae, Facalicatena fissicatena, Clostridium symbiosum, Facalibacterium prausnitizii more abundant group than group. Bacteroides koreensis, Oscillibacter ruminantium, uniformis, Blautia wexlerae regardless patterns microbial varied affecting risk. interaction tightly regulated 0.001). Metagenomic an inverse abundance T2DM, energy utility, butanoate propanoate metabolism, insulin signaling pathway In conclusion, play role pathogenesis, particularly within providing valuable insights link population.

Язык: Английский

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Impact of cholecystectomy on the gut-liver axis and metabolic disorders

Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2024, Номер 48(7), С. 102370 - 102370

Опубликована: Май 9, 2024

Язык: Английский

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Depressive disorder prevention by DIET crosslink: Diet, intestinal microbiota, enzyme and traits of metabolism

Trends in Food Science & Technology, Год журнала: 2024, Номер 150, С. 104596 - 104596

Опубликована: Июнь 14, 2024

Язык: Английский

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