Inflammation Research, Год журнала: 2023, Номер 72(9), С. 1839 - 1859
Опубликована: Сен. 1, 2023
Язык: Английский
Journal of Chemistry, Год журнала: 2024, Номер 2024, С. 1 - 21
Опубликована: Май 31, 2024
Absorption of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.
Язык: Английский
Процитировано
29
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Янв. 29, 2024
Numerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of channels. Abundant associated with oxidative stress have been documented, including Parkinson’s, Alzheimer’s, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington’s disease. Reactive oxygen nitrogen species compounds trigger posttranslational alterations that target specific sites within subunits responsible for assembly. These include adjustment cysteine residues through reactions induced by reactive (ROS), nitration, S-nitrosylation assisted nitric oxide tyrosine peroxynitrite. Several channels directly investigated their functional responses to oxidizing agents stress. This review primarily explores relationship potential links between in conditions, such as cerebellar ataxias Parkinson’s correlation could hold promise developing innovative therapies common diseases.
Язык: Английский
Процитировано
22
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3010 - 3010
Опубликована: Март 5, 2024
This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.
Язык: Английский
Процитировано
17
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(8), С. 3327 - 3361
Опубликована: Май 13, 2024
Mitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS–STING pathway, crucial innate immunity. This pathway responds DNA and associated with cellular stress. Our review explores molecular details regulatory mechanisms of mitophagy pathway. We critically evaluated literature demonstrating how dysfunctional leads neuroinflammatory conditions, primarily through accumulation mitochondria, activating activation prompts production proinflammatory cytokines, exacerbating neuroinflammation. emphasizes interaction between Effective might suppress offering protection against Conversely, impaired may activate potentially leading chronic Additionally, we explored this influences neurodegenerative disorders, suggesting a common mechanism in such diseases. In conclusion, there need additional targeted research unravel complexities mitophagy–cGAS–STING interactions their role neurodegeneration. highlights potential therapies targeting these pathways, which could lead new treatments conditions. synthesis enhances our understanding foundations neuroinflammation opens therapeutic avenues disease research.
Язык: Английский
Процитировано
16
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 3, 2025
Oxidative stress and neuroinflammation are recognized as key factors in the development of neurodegenerative diseases, yet effective interventions biomarkers to address oxidative these conditions limited. Uric acid (UA), traditionally associated with gout, is now gaining prominence a potential target diseases. Soluble UA stands out one most vital antioxidant compounds produced by human body, accounting for up 55% extracellular capacity neutralize free radicals. While there increasing evidence supporting neuroprotective properties Parkinson's disease Alzheimer's disease, gaps knowledge still exist regarding underlying mechanisms how effectively translate benefits into clinical practice. Moreover, current elevation therapy exhibits unstable properties, individual variability, even adverse effects, limiting its applications. This review consolidates recent advancements understanding exerts effects on diseases emphasizes dual roles managing neuroinflammation. Additionally, elucidates through which confers neuroprotection. Based this, underscores significance biomarker aims provide comprehensive therapeutic target, while also addressing possible challenges implementation.
Язык: Английский
Процитировано
2
Neurogenetics, Год журнала: 2025, Номер 26(1)
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
2
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(20), С. 12289 - 12289
Опубликована: Окт. 14, 2022
The bidirectional interaction between the gut microbiota (GM) and Central Nervous System, so-called brain axis (GMBA), deeply affects function has an important impact on development of neurodegenerative diseases. In Parkinson’s disease (PD), gastrointestinal symptoms often precede onset motor non-motor manifestations, alterations in GM composition accompany pathogenesis. Several studies have been conducted to unravel role dysbiosis intestinal permeability PD progression, but therapeutic diagnostic applications modifying approaches remain be fully elucidated. After a brief introduction involvement GMBA disease, we present evidence for leaky patients. According these data, then review potential GM-based signatures serve as biomarkers highlight emerging probiotics, prebiotics, antibiotics, dietary interventions, fecal transplantation supportive PD. Finally, analyze mutual influence commonly prescribed medications gut-microbiota, offer insights also nasal oral pathology, thus providing comprehensive up-to-date overview microbial features diagnosis treatment.
Язык: Английский
Процитировано
46
Biomedicines, Год журнала: 2022, Номер 10(7), С. 1706 - 1706
Опубликована: Июль 14, 2022
Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in number of people that are affected and constantly aging population. Among all NDs, Alzheimer’s Parkinson’s disease most common, many efforts been made development effective reliable therapeutic strategies. The intranasal route drug administration offers numerous advantages, such as bypassing blood–brain barrier providing direct entrance brain through olfactory trigeminal neurons. present review summarizes available information on recent advances micro- nanoscale nose-to-brain drug-delivery systems novel strategy for treatment disease. Specifically, polymer- lipid-base nanoparticles studied feasible approach bioavailability certain drugs. Furthermore, nanocomposites discussed suitable formulation into nasal cavity.
Язык: Английский
Процитировано
42
Antioxidants, Год журнала: 2022, Номер 11(10), С. 2049 - 2049
Опубликована: Окт. 18, 2022
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic have received growing interest as treatment options in neurodegenerative conditions. various experimental settings, they displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, neuroprotective effects. However, due to numerous targets downstream effectors of their action, cellular molecular mechanisms underlying these effects are rather complex still under discussion. Cannabinoids able neutralize free radicals modulate production reactive oxygen species activity antioxidative systems acting on CB1 CB2 cannabinoid receptors. The activation receptors stimulates signaling pathways involved defense survival (such phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), Nrf2 pathways) regulates glutamatergic signaling, N-methyl-D-aspartate (NMDA) receptors, calcium influx, induction Ca2+-regulated cascades, whereas mediated by suppression microglial release prooxidative proinflammatory mediators. This review summarizes main new advances understanding cannabinoids. Because plethora possible pharmacological interventions related oxidative stress cannabinoid-mediated neuroprotection, future research should be directed towards a better interplay between activated signal transduction with aim improve efficacy targeting endocannabinoid system.
Язык: Английский
Процитировано
39