The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9317 - 9317

Опубликована: Май 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Язык: Английский

---

The crucial function of gut microbiota on gut-liver repair

hLife, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation

Inflammation, Год журнала: 2022, Номер 46(1), С. 35 - 46

Опубликована: Авг. 11, 2022

Язык: Английский

---

Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota–Lipid Metabolism–Th1/Th2/Th17 Cells Axis

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(50), С. 20073 - 20091

Опубликована: Дек. 8, 2023

Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aimed to explore the therapeutic effects underlying mechanisms of G-Rg1 on colitis complicated by obesity. The results indicate that effectively alleviates in obese mice improves serum lipid levels liver function. Importantly, improved composition gut microbiota with colitis, increases alpha diversity indexes Sobs, Ace, Chao, a significant down-regulation relative abundance Romboutsia, up-regulation Rikenellaceae_RC9_gut_group, Lachnospiraceae_NK4A136_group, Enterorhabdus, Desulfovibrio, Alistipes. Meanwhile, metabolism colonic contents colitis. Additionally, significantly reduced percentages helper T (Th)1, Th17, central memory (TCM), effector (TEM) cells while increasing Naïve Th2 cells. In conclusion, could be promising option for alleviating obesity through regulation as well Th1/Th2/Th17 cell differentiation.

Язык: Английский

---

Baicalin nanoemulsion mitigates cisplatin-induced hepatotoxicity by alleviating oxidative stress, inflammation, and restoring cellular integrity

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117231 - 117231

Опубликована: Янв. 1, 2025

Язык: Английский

---

Evaluating the Efficacy of Secondary Metabolites in Antibiotic-Induced Dysbiosis: A Narrative Review of Preclinical Studies

Antibiotics, Год журнала: 2025, Номер 14(2), С. 138 - 138

Опубликована: Фев. 1, 2025

Background/Objectives: Drug-induced dysbiosis, particularly from antibiotics, has emerged as a significant contributor to chronic diseases by disrupting gut microbiota composition and function. Plant-derived secondary metabolites, such polysaccharides, polyphenols, alkaloids, saponins, show potential in mitigating antibiotic-induced dysbiosis. This review aims consolidate evidence preclinical studies on the therapeutic effects of metabolites restoring microbial balance, emphasizing their mechanisms efficacy. Methods: A narrative was conducted using PubMed, Scopus, Web Science. Studies were selected based specific inclusion criteria, focusing animal models treated with for The search terms included “gut microbiota”, “antibiotics”, “secondary metabolites”. Data extraction focused alterations, metabolite-specific effects, action. Relevant findings systematically analyzed summarized. Results: Secondary demonstrated diverse impact dysbiosis modulating composition, reducing inflammation, supporting host biological markers. Polysaccharides polyphenols restored Firmicutes/Bacteroidetes ratio, increased beneficial taxa Lactobacillus Bifidobacterium, suppressed pathogenic bacteria like Escherichia-Shigella. Metabolites triterpenoid saponins enhanced barrier integrity upregulating tight junction proteins, while alkaloids reduced inflammation proinflammatory cytokines (e.g., TNF-α, IL-1β). These also improved short-chain fatty acid production, which is crucial systemic health. While primary focus, other drug classes PPIs, metformin) require further investigation. Conclusions: promise managing improving Future research should explore applicability types drug-induced validate human enhance clinical relevance.

Язык: Английский

---

Baicalin restores innate lymphoid immune imbalance during exacerbation of COPD

Immunologic Research, Год журнала: 2025, Номер 73(1)

Опубликована: Апрель 16, 2025

Chronic obstructive pulmonary disease (COPD) is characterized by immune dysregulation, including altered innate lymphoid cell (ILC) responses, particularly during exacerbations (ECOPD). Baicalin, a natural compound prevalent in various herbal medicines, has shown promise as therapeutic candidate ECOPD. However, its potential and molecular mechanism for addressing ILC imbalance ECOPD remain poorly understood. First, this study conducted cross-sectional analysis of responses stable COPD patients those experiencing exacerbations. Then, clinical findings skewed immunity were validated cigarette smoke lipopolysaccharide-induced mouse models. Lastly, the effect baicalin on restoring homeostasis was investigated experimental Significant downregulation ILC2 observed exacerbations, accompanied increased ILC1 ILC3 cases associated with bacterial infections. Notably, elevated IL-22 levels group. Administration recombinant models disrupted lung homeostasis, specifically inhibiting accumulation ILC2. Proteomics transcriptomics analyses suggested mediator type 2 suppression creating environment that favors 1 3 immunity. Treatment effectively restored enhancing recruitment activation while suppressing responses. Importantly, attenuated production from ILC3, highlighting an inhibitor. Baicalin demonstrates strategy partially production. Clinical registration The registered Chinese Trial Registry (ChiCTR2100050683).

Язык: Английский

---

Xiaohuang Qudan decoction alleviates ANIT-induced cholestatic liver injury by inhibiting the JAK2/STAT3 pathway and regulating TH17/Treg

Chinese Journal of Natural Medicines, Год журнала: 2025, Номер 23(4), С. 457 - 470

Опубликована: Апрель 1, 2025

Язык: Английский

---

Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 9, 2024

Baicalin is a flavonoid glycoside obtained from the dried root of

Язык: Английский

---

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

Frontiers in Microbiology, Год журнала: 2023, Номер 13

Опубликована: Янв. 4, 2023

Baicalin (BA) is among the most effective and abundant flavonoids extracted from Scutellaria baicalensis that may be utilized to treat diseases associated with hepatic fibrosis (HF). Through network pharmacology, gut microbiota, experimental validation, this research intends elucidate multi-target mechanism of BA on HF. targets were screened using databases literature. As a result, In anti-HF mechanism, 191 HF-associated interact, 9 specific indicating BA's closely linked microbiota. Consequently, rat intestinal content samples obtained examined 16S rRNA sequencing. BA-treated group, microbiota was positively regulated at phylum,and genus levels, Lactobacillus performing significantly. The study concluded has multi-targeted effect changed microbial ecosystem.

Язык: Английский

---