Basic & Clinical Pharmacology & Toxicology,
Год журнала:
2025,
Номер
136(4)
Опубликована: Март 20, 2025
This
study
aimed
to
explore
the
effect
and
mechanism
of
baicalin
on
L-glutamate-induced
oxidative
stress
injury
in
hippocampus
mice.
Forty
mice
were
divided
into
five
groups:Sham,
model,
N-acetyl-L-cysteine
(NAC)
(BA-7.5
mg/kg
BA-15
mg/kg).
A
model
excitatory
amino
acid
toxicity
with
was
induced
by
injecting
L-glutamate
lateral
ventricle.
Drugs
administered
intraperitoneally
post-modelling.
Six
hours
later,
behavioural
tests
performed.
Brain
lesions
observed
via
HE
staining,
neuronal
apoptosis
evaluated
using
TUNEL
staining.
The
levels
superoxide
dismutase
(SOD)
malondialdehyde
(MDA)
determined
biochemical
methods.
Fluorescent
staining
employed
detect
expression
reactive
oxygen
species
(ROS).
Cytochrome
C
(CytC)
assessed
immunohistochemistry.
Nrf2,
HO-1,
SOD2
catalase
(Cat)
detected
qPCR
WB.
showed
that
motion
distance
pain
threshold
reduced
group.
MDA,
ROS
CytC
increased,
while
SOD
Cat
decreased
after
modelling.
CA3
region
exhibited
pathological
changes,
rate
TUNEL-positive
increased.
Baicalin
could
reverse
these
especially
BA-7.5
mg/kg.
can
reduce
L-glutamate,
might
be
related
activation
Nrf2/HO-1
pathway.
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2023,
Номер
9, С. 100326 - 100326
Опубликована: Ноя. 7, 2023
Chinese
Skullcap
(Scutellaria
baicalensis)
is
a
traditional
medicinal
herb
with
rich
history
of
use
in
Traditional
Medicine
(TCM).
This
review
aims
to
provide
an
updated
overview
the
phytochemical
constituents
and
pharmacological
attributes
Skullcap,
shedding
light
on
its
potential
therapeutic
applications.
A
comprehensive
search
scientific
databases,
including
PubMed,
Scopus,
Web
Science,
was
conducted
gather
relevant
literature
published
up
September
2023.
Keywords
such
as
"Scutellaria
baicalensis,"
"phytochemicals,"
"pharmacological
properties"
were
used
identify
pertinent
studies.
found
contain
diverse
array
constituents,
flavonoids,
alkaloids,
terpenoids,
baicalin
baicalein
being
most
prominent
bioactive
compounds.
These
compounds
have
demonstrated
wide
range
activities,
anti-inflammatory,
antioxidant,
anti-cancer,
neuroprotective,
hepatoprotective
effects.
Additionally,
has
been
investigated
for
treating
various
diseases,
cancer,
cardiovascular
disorders,
neurodegenerative
conditions.
represents
compelling
avenue
future
development,
emphasizing
ongoing
need
exploration
clinical
investigation.
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 775 - 775
Опубликована: Июнь 27, 2024
Rheumatoid
arthritis
(RA)
is
a
persistent
autoimmune
disorder
that
characterized
by
joint
inflammation,
discomfort,
and
impairment.
Despite
the
existence
of
several
therapeutic
approaches,
their
effectiveness
often
restricted
may
be
linked
to
unfavorable
side
effects.
Consequently,
there
has
been
growing
interest
in
investigating
naturally
derived
compounds
as
plausible
agents
for
RA
disease.
The
objective
this
review
summarize
existing
preclinical
clinical
evidence
regarding
efficacy
extracted
plant
extracts
treatment
RA,
focusing
on
anti-inflammatory,
anti-oxidative,
immunomodulatory
properties.
Some
problems
with
using
natural
chemicals
are
uneven
quality
commercially
available
preparations
poor
bioavailability
these
compounds.
Future
investigations
should
focus
improving
formulations,
conducting
thorough
trials,
exploring
different
techniques
fully
utilize
intrinsic
potential
treating
RA.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 5, 2024
The
prevalence
of
colorectal
cancer
is
increasing
worldwide,
and
despite
advances
in
treatment,
(CRC)
remains
the
top
three
for
mortality
due
to
several
issues,
including
drug
resistance
low
efficiency.
There
evidence
that
baicalin
baicalein,
novel
small
molecule
inhibitor
extracts
Chinese
herb
Scutellaria
baicalensis,
have
better
anti-colorectal
effects
are
less
likely
induce
cells.
present
review
article
explains
anti-proliferative
properties
baicalein
context
against
CRC.
Additionally,
it
explores
underlying
mechanisms
by
which
these
compounds
modulate
diverse
signaling
pathways
associated
with
apoptosis,
cell
proliferation,
tumor
angiogenesis,
invasion,
metastasis,
microenvironment.
Moreover,
this
highlights
inhibitory
effect
inflammatory-cancer
transformation
near-term
therapeutic
strategy
using
them
as
adjuvant
agents
chemotherapy.
Saudi Pharmaceutical Journal,
Год журнала:
2024,
Номер
32(6), С. 102100 - 102100
Опубликована: Май 14, 2024
We
previously
demonstrated
that
baicalin
had
efficacy
against
gouty
arthritis
(GA)
by
oral
administration.
In
this
paper,
a
novel
baicalin-loaded
microemulsion-based
gel
(B-MEG)
was
prepared
and
assessed
for
the
transdermal
delivery
of
GA.
The
preparation
method
capability
B-MEG
screened
optimized
using
central
composite
design,
Franz
diffusion
cell
experiments,
split-split
plot
design.
Skin
irritation
tests
were
performed
in
guinea
pigs.
anti-gout
effects
evaluated
mice.
comprised
50
%
pH
7.4
phosphate
buffered
saline,
4.48
ethyl
oleate,
31.64
tween
80,
13.88
glycerin,
2
borneol,
0.5
clove
oil
xanthan
gum,
with
content
(10.42
±
0.08)
mg/g
particle
size
(15.71
0.41)
nm.
After
12
h,
cumulative
amount
permeated
from
(672.14
44.11)
μg·cm
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 501 - 501
Опубликована: Янв. 9, 2025
Ischemic
stroke,
caused
by
blocked
cerebral
blood
flow,
requires
prompt
intervention
to
prevent
severe
motor
and
cognitive
impairments.
Despite
extensive
drug
development
efforts,
the
failure
rate
of
clinical
trials
remains
high,
highlighting
need
for
novel
therapeutic
approaches.
This
study
investigated
potential
a
natural
herbal
extract
mixture
Astragalus
mongholicus
Bunge
(AM)
Scutellaria
baicalensis
Georgi
(SB),
traditionally
used
in
Eastern
Asian
medicine
(EAHM)
ischemic
stroke
treatment.
Using
transient
middle
artery
occlusion
(tMCAO)
photothrombotic
(PTB)
mouse
models,
oral
administration
AM-SB
was
evaluated
during
both
acute
chronic
phases.
Results
showed
that
significantly
reduced
infarction
volume,
inflammation
(IL-1β,
TNF-α),
pyroptosis-related
markers
(NLRP3,
GSDMD,
ASC,
Caspase-1),
while
decreasing
gliosis
improving
metabolites.
Behavioral
assessments
revealed
early
sustained
enhanced
functions,
as
measured
mNSS,
Rotarod,
Novel
Object
Recognition,
Passive
Avoidance
tests.
These
findings
suggest
is
promising
alternative
therapy
management.
