Improvement effects of green tea and pumpkin oils on myelin oligodendrocyte glycoprotein-induced Multiple sclerosis in rats DOI Creative Commons
Nahed S. Lamloum,

Hanan A. Soliman,

Rasha R. Ahmed

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 111, С. 105876 - 105876

Опубликована: Ноя. 10, 2023

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) associated with significant progressive neurodegeneration. There lot interest in use plant-based essential oils traditional medicine to treat and prevent human illnesses, including MS. This research aimed assess neuroprotective effects green tea oil (GTO) pumpkin (PO) against myelin oligodendrocyte glycoprotein (MOG)-induced MS Wistar rats as well investigate underlying molecular mechanisms. The were divided into four groups: group 1, normal control; 2, MOG-injected; groups 3 4, MOG-injected treated 5 ml/kg body weight each GTO PO, respectively. chemical profiles components within PO identified using gas chromatography-mass spectrometry (GC–MS). Treatment substantially improved decreased dopamine, serotonin, norepinephrine, acetylcholine levels brain rats. It also suppressed elevated epinephrine levels. histological injuries cortical tissue notably after supplementing PO. Furthermore, lipid peroxidation serum INF-β concentration significantly lower GSH, SOD, GPx, coenzyme Q10, α-tocopherol enhanced by supplementaion. Additionally, administration upregulated Nrf2, Bcl-2, PCNA while downregulated TNF-α, NF-κB, iNOS, p53, Bax expression Taken together, these findings suggest that efficiently ameliorate MOG-induced via enhancing antioxidant, anti-inflammatory, anti-apoptotic effects.

Язык: Английский

Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms DOI
Mazyar Yazdani

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5665 - 5679

Опубликована: Янв. 15, 2024

Язык: Английский

Процитировано

3
Establishment of the Diagnostic Signature of Ferroptosis Genes in Multiple Sclerosis DOI Creative Commons

Yang Yang,

Qianqian Bai,

Fangfei Liu

и другие.

Biochemical Genetics, Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Ferroptosis is a novel form of membrane-dependent cell death that differs from other modalities such as necrosis, apoptosis, and autophagy. Multiple sclerosis (MS) chronic inflammatory disease the central nervous system primarily affecting brain spinal cord neurons. Although pathogenesis these two conditions may seem unrelated, recent studies have indicated connection between ferroptosis multiple sclerosis. In fact, plays significant role in development MS, evidenced by presence elevated iron levels metabolism abnormalities brains, cords, neurons MS patients. These disrupt homeostasis within cells, leading to occurrence ferroptosis. However, there currently lack research on diagnostic value ferroptosis-related genes this study, we employed bioinformatics methods identify ( ATM, GSK3B, HMGCR, KLF2, MAPK1, NFE2L1, NRAS, PCBP1, PIK3CA, RPL8, VDAC3 ) associated with diagnosis constructed model. The results demonstrated model accurately identified patients’ condition. Subsequently, subgroup analysis was performed based expression genes, dividing patients into high low groups. showed differences immune function infiltration Our study not only confirms correlation but also demonstrates disease. This provides guidance for clinical practice direction further mechanistic research.

Язык: Английский

Процитировано

3
IgG Biomarkers in Multiple Sclerosis: Deciphering Their Puzzling Protein A Connection DOI Creative Commons

Leonard Apeltsin,

Xiaoli Yu

Biomolecules, Год журнала: 2025, Номер 15(3), С. 369 - 369

Опубликована: Март 4, 2025

Identifying reliable biomarkers in peripheral blood is critical for advancing the diagnosis and management of multiple sclerosis (MS), particularly given invasive nature cerebrospinal fluid (CSF) sampling. This review explores role B cells immunoglobulins (Igs), IgG IgM, as MS. cell oligoclonal bands (OCBs) CSF are well-established diagnostic tools, yet remain underdeveloped. Emerging evidence highlights structural functional variations immunoglobulin that may correlate with disease activity progression. A recent novel discovery aggregates MS patients fail to bind Protein reveals promising potential confirms previous findings unique features G link between superantigen These aggregates, enriched IgG1 IgG3 subclasses, exhibit properties, including mutations framework region 3 (FR3) IGHV3 genes, associated complement-dependent neuronal apoptosis. Data based on ELISA have demonstrated plasma can distinguish from healthy controls other central nervous system (CNS) disorders high accuracy differentiate subtypes. suggests a non-invasive monitoring.

Язык: Английский

Процитировано

0
Uncovering the Causal Link Between Obesity‐Associated Genes and Multiple Sclerosis: A Systematic Literature Review DOI Creative Commons
Ali Jafari, Sara Khoshdooz,

Melika Arab Bafrani

и другие.

Brain and Behavior, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background: Multiple sclerosis (MS) is a multifaceted neurodegenerative disorder influenced by genetics and lifestyle. This systematic literature review investigates the role of six obesity‐associated genes, including fat mass ( FTO ), FAS apoptosis inhibitory molecule 2 FAIM2 Niemann–Pick disease type C1‐like 1 NPC1 glucosamine‐6‐phosphate deaminase GNPDA2 melanocortin‐4 receptor MC4R brain‐derived neurotrophic factor BDNF ) in context MS. Methods: A search was executed using Embase, Scopus, Cochrane, Web Science, PubMed databases from inception to July 2024. The related keywords employed during process are “fas apoptotic 2,” “Niemann–Pick C1,” “fat obesity‐associated,” “melanocortin‐4 receptor,” “brain‐derived factor,” “glucosamine‐6‐phosphate “multiple sclerosis.” Results: Out 2108 papers, 27 were entered into present review. gene may affect MS susceptibility through metabolic inflammatory pathways. genes contribute pathogenesis, though their precise roles still being elucidated. have some connections with but requires further clarification. has demonstrated significant neuroprotective anti‐inflammatory effects, suggesting its potential impact on progression. plays complex neuronal survival repair influence risk Conclusion: Our findings that obesity‐related course, revealing novel insights genetic underpinnings

Язык: Английский

Процитировано

0
Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions DOI Creative Commons
Cathrin E. Hansen, Julia Konings, Gábor Tóth

и другие.

Acta Neuropathologica, Год журнала: 2025, Номер 149(1)

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Cyclooxygenase-1 and cyclooxygenase-2 densities measured using positron emission tomography are not altered in the brains of individuals with stable multiple sclerosis DOI
Shiyu Tang, Daniel M. Harrison,

Amanda Bardhoshi

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system that involves immune-mediated demyelination and axonal degeneration. Clinical imaging techniques play critical role in diagnosing assessing prognosis of MS. Magnetic resonance has been most frequently used to visualize detect acute active lesions, which are key indicators clinical course illness. Previous research also highlighted effectiveness translocator protein 18-kDa (TSPO) positron emission tomography (PET) for identifying lesions progressive pathology. Building on this work, present study PET explore cyclooxygenase-1 -2 (COX-1 COX-2)—key enzymes involved neuroinflammation—in individuals with Five participants MS were recruited, identified using 7 Tesla MRI. No significant differences COX radioligand binding observed co-registered images between lesioned areas normal-appearing brain tissues, nor healthy volunteers. The negative findings underscore complexity pathology raise several important considerations planning future studies

Язык: Английский

Процитировано

0
Neuroprotective strategies in multiple sclerosis: a status update and emerging paradigms DOI Creative Commons

Catalina Coclitu,

Cris S. Constantinescu,

Radu Tanasescu

и другие.

Expert Review of Neurotherapeutics, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

MS is a disease continuum in which maladaptive inflammation and neurodegeneration co-occur from onset evolve over time. Recent progress the understating of pathobiology creates new perspectives for novel neuroprotective therapeutic strategies. The authors briefly review mechanisms underlying discuss current emerging strategies to promote neuroprotection MS. Data were derived large part extensive published literature available on PubMed (up 5th March 2025). Strategies should be ideally implemented early course They consider interplay between neuroinflammation, demyelination neurodegeneration, changes CNS innate immunity resident cells, axonal mitochondrial dysfunction (axonal response mitochondria demyelination, ARMD), remyelination. There need adequate biomarkers can help monitor outcomes target engagement . Comorbidities aging worsen impair neuroprotective/regenerative processes. Candidate drugs preclinical clinical studies tested multi-arm multistage adaptive trials.

Язык: Английский

Процитировано

0
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination DOI Creative Commons
Kai Chen,

Xiaojin Wei,

Ruixuan Wang

и другие.

The Journal of Headache and Pain, Год журнала: 2023, Номер 24(1)

Опубликована: Окт. 24, 2023

BMP7 has been shown to have neuroprotective effects and alleviate demyelination. However, its role in trigeminal neuralgia (TN) not well investigated. The current study aims determine whether plays a demyelination, on pain behaviors mechanism of action rats with TN.We used an infraorbital-nerve chronic-constriction injury (ION-CCI) establish rat model TN. Adeno-associated viruses (AAVs) were injected into the upregulate or downregulate BMP7. mechanical withdrawal thresholds (MWT) injured detected using Von Frey filaments. changes expression levels oligodendrocyte (OL) markers examined by western blotting, quantitative real-time PCR, immunofluorescence, transmission electron microscopy.The ION-CCI induced allodynia, loss OLs reduction Short-hairpin RNA (shRNA)-BMP7 that inhibited also caused OLs, may be OL apoptosis. Overexpressing spinal subnucleus caudalis(VC) AAV-BMP7 relieved all three phenotypes CCI, alleviating Two signal pathways associated apoptosis, STAT3 p65, significantly downregulated VC after CCI rescued overexpression.BMP7 can TN reducing apoptosis subsequent behind this protection could BMP7-mediated activation NF-κB/p65 signaling pathway decrease Importantly, our presents clear evidence support as possible therapeutic target for treatment

Язык: Английский

Процитировано

7
Primary Progressive Multiple Sclerosis—A Key to Understanding and Managing Disease Progression DOI Open Access

Izabela Sempik,

Edyta Dziadkowiak, Helena Moreira

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8751 - 8751

Опубликована: Авг. 11, 2024

Primary progressive multiple sclerosis (PPMS), the least frequent type of (MS), is characterized by a specific course and clinical symptoms, it associated with poor prognosis. It requires extensive differential diagnosis often long-term follow-up before its correct recognition. Despite recent progress in research into treatment for MS, management this disease still poses challenge. Considering modern concept progression “smoldering” throughout all stages disease, thorough exploration PPMS may provide better insight mechanisms potential implications. The goal study was to review current evidence from investigations PPMS, including background, characteristics, biomarkers therapeutic opportunities. Processes underlying CNS damage are discussed, chronic immune-mediated inflammation, neurodegeneration, remyelination failure. A clinical, biochemical radiological presented, which useful monitoring predicting PPMS. Therapeutic options summarized, approved therapies, ongoing trials future directions investigations. implications findings would be reliable assessments outcomes, improvements individualized approaches and, hopefully, novel targets, relevant progression.

Язык: Английский

Процитировано

2
Plasma IgG aggregates as biomarkers for multiple sclerosis DOI

Wenbo Zhou,

Michael W. Graner, Cheryl L. Beseler

и другие.

Clinical Immunology, Год журнала: 2023, Номер 256, С. 109801 - 109801

Опубликована: Окт. 9, 2023

Язык: Английский

Процитировано

5