Генетика, Год журнала: 2023, Номер 59(12), С. 1382 - 1392
Опубликована: Дек. 1, 2023
Язык: Английский
Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)
Опубликована: Май 13, 2024
Abstract Background The study of plant-based medications, or phytomedicine, involves a wide spectrum biological activities. Due to the existence secondary metabolites, herbal medicine has been used and practiced throughout history for treatment both acute chronic conditions. Over past century so, numerous novel compounds with medicinal potential have derived from plants. In age growing super infections emergence resistant strains, natural medicines are inspiring optimism. Main body abstract review discusses role as antibacterial agents their use in wound care management wounds critical metabolites plants fighting bacterial infections. Some such St. John’s wort (SJW) ( Hypericum perforatum ), Rosemary Rosmarinus officinalis Ginger Zingiber officinale nopal cactus Opuntia ficusindica L. )) also possess range activities can give synergistic effect if combined antibiotics. addition, biopolymers play an important well physiological processes skin (hemostasis, inflammation, proliferation, remodelling). Method A narrative papers relevant phytomedicine treating was conducted by using electronic databases PubMed, CrossREF, Google Scholar. Short conclusion Phytomedicine is one top options illnesses millions people around world. To learn about bioactive components plants, medical benefits, additive effects enhance action substantial new studies still needed. Graphical
Язык: Английский
Процитировано
7
Antibiotics, Год журнала: 2025, Номер 14(5), С. 430 - 430
Опубликована: Апрель 24, 2025
Background: The use of antimicrobial peptides (AMPs) as biotechnological tools is an area growing interest in the research that seeks to improve crop defense. SmAPα1–21 and SmAPγ27–44 were previously reported inhibit Fusarium graminearum, permeabilize plasma membrane induce cytoplasmic disorganization. To exert its activity, initially enters through basal apical cells F. graminearum conidia then displays a general but non-homogeneous distribution cytoplasm all conidial cells, contrast. Methods: We analyzed, focusing on interaction, mode action SmAPγ27–44, peptide based γ-core defensins DefSm2-D DefSm3, SmAPα1–21, α-core DefSm2-D. Additionally, we compared behavior with SmAP3α1–21 DefSm3 no activity against graminearum. Results: In this study, showed discrete intracellular localization. Furthermore, both disrupted membrane, different modes action. When large unilamellar liposomes (LUVs) containing phosphatidic acid ergosterol used filamentous fungal model, strongly induced aggregation concomitantly solubilization maximal insertion tryptophan moiety into membrane’s hydrophobic interior. comparison, high effect ζ potential anionic vesicles, vesicle capacity after reaching concentration threshold, moderate transfer membrane. SmAP3α1–21, other hand, poor superficial adsorption liposomes. Conclusions: view our results, cell penetration peptide-like was pictured for defensin-derived classical AMP observed one.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 483 - 483
Опубликована: Дек. 28, 2022
The γ-core motif is a structural element shared by most host antimicrobial peptides (AMPs), which supposed to contribute their properties. In this review, we summarized the available data on of plant AMPs. We describe that have been shown exhibit inhibitory activity against and human bacterial fungal pathogens make them attractive scaffolds for development novel anti-infective agents. Their advantages include origin from natural AMP sequences, broad-spectrum potent activity, cost-effective production. addition, some combine immunomodulatory functions, thus broadening spectrum practical applications. Some act synergistically with antimycotics fungicides, so combinations conventionally used antifungal agents can be suggested as an effective strategy reduce doses potentially harmful chemicals. presented information will pave way design antimicrobials basis peptides, find application in medicine protection crops diseases.
Язык: Английский
Процитировано
10
Journal of Fungi, Год журнала: 2024, Номер 10(4), С. 258 - 258
Опубликована: Март 28, 2024
Peptides play an essential role in plant development and immunity. Filipendula ulmaria, belonging to the Rosaceae family, is a medicinal which exhibits valuable pharmacological properties. F. ulmaria extracts vitro inhibit growth of variety human pathogens. The peptides defense against pathogens remains unknown. objective this study was explore repertoire antimicrobial (AMPs) defense-related signaling peptide genes expressed by response infection with Bipolaris sorokiniana using RNA-seq. Transcriptomes healthy infected plants at two time points were sequenced on Illumina HiSeq500 platform de novo assembled. A total 84 encoding novel putative AMPs predicted transcriptomes. They belong known, as well new, families. Transcriptional profiling disclosed complex expression patterns identified both up- down-regulated each family. Among differentially genes, vast majority down-regulated, suggesting suppression immune fungus. 13 up-regulated, indicating their possible involvement triggering response. After functional studies, encoded can be used biofungicides resistance inducers.
Язык: Английский
Процитировано
1
Russian Journal of Genetics, Год журнала: 2024, Номер 60(10), С. 1341 - 1354
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Генетика, Год журнала: 2024, Номер 60(10), С. 56 - 70
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
0
Опубликована: Ноя. 23, 2023
Global agriculture has been forced to increase food production feed the growing human population, while confronting various environmental obstacles such as global warming, resistance pathogens, and constraints on arable land caused by soil salinity, drought, rising sea level, saltwater intrusion, urbanization. Regarding abiotic stresses, salinity is a worldwide problem for agricultural production. Many efforts, therefore, have made cope with challenges, however, progress of salinization, which mainly accelerated anthropogenic activities, likely faster than our in finding ways deal this problem. In addition, drought represents threat major crops. pests pathogens cause significant crop losses diminish security. Among strategies that investigated applied plant science, antimicrobial peptides derived from plants caught widespread attention scientists since these exhibit beneficial biological activities. there reports roles active properties against biotic stresses. Non-specific lipid transfer proteins, thionins, systemins, defensins, cyclotides, heveins-like are common found be involved defense system fungi insect pests. Based their potential ability protect crops pests, bacteria, pathogenic fungi, use peptide genes creating transgenic largely conducted during last decades, studies obtained positive results growth bacteria. This review will focus latest related stress tolerance plants. We also update current development peptide-based
Язык: Английский
Процитировано
1
Russian Journal of Genetics, Год журнала: 2023, Номер 59(12), С. 1310 - 1319
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
1
Генетика, Год журнала: 2023, Номер 59(12), С. 1382 - 1392
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
0