Molecular Physics,
Год журнала:
2024,
Номер
122(18)
Опубликована: Фев. 22, 2024
In
this
work,
photophysical
properties
of
the
flavone-based
dyes
APG,
BCN,
CYS,
LUT,
and
OX-A
were
investigated
using
TD-DFT
calculations
at
PBE0/6-311++G
(d,p)
level
in
gas
phase
solvent
media.
The
structural
parameters,
absorption
emission
spectra,
potential
energy
curves,
natural
charges,
electron
density
properties,
reduced
gradient,
protein–ligand
docking
calculated.
S1
state,
normal
form
all
was
directly
converted
to
its
tautomeric
T
by
no
barrier.
results
demonstrated
that
O1–H2···O6
H-bonding
S0
state
is
stronger
than
O1···H2–O6
one
state.
Upon
photoexcitation
flavones
exhibit
keto
fluorescence
near-infrared
(NIR)
wavelengths
848.0
nm
for
APG
1143.1
OX-A,
making
application
these
molecules
more
attractive
medical
physiological
diagnostics.
addition,
anti-aging
flavonoids
studied
process
on
two
aging
targets
brain-derived
neurotrophic
factor
(BDNF)
nerve
growth
factors
(NGF).
Our
study
can
provide
insights
into
design
a
ESIPT
fluorescent
probe
which
might
inspire
future
applications
field
chemical
sensing,
imaging
drug
design.
Biomedicines,
Год журнала:
2023,
Номер
11(7), С. 2078 - 2078
Опубликована: Июль 24, 2023
In
recent
years,
plant
polyphenols
have
become
a
popular
focus
for
the
development
of
novel
functional
foods.
Polyphenols,
class
bioactive
compounds,
including
flavonoids,
phenolic
acids,
and
lignans,
are
commonly
found
in
plant-based
diets
with
variety
biological
actions,
antioxidant,
anti-inflammatory,
anticancer
effects.
Unfortunately,
not
widely
used
nutraceuticals
since
many
chemicals
possess
poor
oral
bioavailability.
Thankfully,
can
be
encapsulated
transported
using
bio-based
nanocarriers,
thereby
increasing
their
Polyphenols'
limited
water
solubility
low
bioavailability
limiting
factors
practical
usage,
but
this
issue
resolved
if
suitable
delivery
vehicles
developed
encapsulating
delivering
polyphenolic
compounds.
This
paper
provides
an
overview
study
nanocarriers
enhancement
polyphenol
bioavailability,
as
well
summary
health
advantages
prevention
treatment
several
diseases.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8250 - 8250
Опубликована: Июль 28, 2024
The
intricate
relationship
between
the
gastrointestinal
(GI)
microbiome
and
progression
of
chronic
non-communicable
diseases
underscores
significance
developing
strategies
to
modulate
GI
microbiota
for
promoting
human
health.
administration
probiotics
prebiotics
represents
a
good
strategy
that
enhances
population
beneficial
bacteria
in
intestinal
lumen
post-consumption,
which
has
positive
impact
on
In
addition,
dietary
fibers
serve
as
significant
energy
source
inhabiting
cecum
colon.
Research
articles
reviews
sourced
from
various
global
databases
were
systematically
analyzed
using
specific
phrases
keywords
investigate
these
relationships.
There
is
clear
association
fiber
intake
improved
colon
function,
gut
motility,
reduced
colorectal
cancer
(CRC)
risk.
Moreover,
state
health
reflected
reciprocal
bidirectional
relationships
among
food,
antioxidants,
inflammation,
body
composition.
They
are
known
their
antioxidant
properties
ability
inhibit
angiogenesis,
metastasis,
cell
proliferation.
Additionally,
they
promote
survival,
immune
inflammatory
responses,
inactivate
pro-carcinogens.
These
actions
collectively
contribute
role
prevention.
different
investigations,
supplements
containing
vitamins
have
been
shown
lower
risk
types.
contrast,
some
evidence
suggests
taking
can
increase
cancer.
Ultimately,
collaborative
efforts
immunologists,
clinicians,
nutritionists,
dietitians
imperative
designing
well-structured
nutritional
trials
corroborate
clinical
efficacy
therapy
managing
inflammation
preventing
carcinogenesis.
This
review
seeks
explore
interrelationships
fiber,
microbiome,
with
particular
focus
potential
implications
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
274, С. 133295 - 133295
Опубликована: Июнь 22, 2024
The
stability
and
bioavailability
of
green
tea
polyphenols,
crucial
for
their
health
benefits,
are
compromised
by
environmental
sensitivity,
limiting
use
in
functional
foods
supplements.
This
study
introduces
a
novel
water-in-oil-in-water
double
emulsion
technique
with
microwave-assisted
extraction,
significantly
enhancing
the
these
compounds.
primary
objective
this
was
to
assess
effectiveness
several
encapsulating
agents,
such
as
gum
Arabic
control
native
modified
starches,
improving
encapsulated
substances'
release
control.
Native
starches
were
chosen
outstanding
film-forming
properties,
encapsulation
efficiency
protecting
bioactive
compounds
from
oxidative
degradation.
combination
maltodextrin
tapioca
starch
improved
phenolic
content
retention,
giving
46.25
±
2.63
mg/g
microcapsules
(GTTA)
41.73
3.24
arabic
(GTGA).
Besides
control,
also
had
most
potent
antioxidant
activity,
45
%
inhibition
(inh%)
DPPH
analysis.
Oat
oil
utilized
its
superior
viscosity
nutritional
profile,
boosting
providing
integrity
indicated
microcapsules'
narrow
span
index
(1.30
0.002).
thermal
behavior
structural
confirmed
using
advanced
methods
Differential
Scanning
Calorimetry
(DSC)
Fourier-Transform
Infrared
Spectroscopy
(FT-IR).
highlights
critical
role
choosing
appropriate
wall
materials
extraction
techniques.
It
sets
new
standard
microencapsulation
applications
food
industry,
paving
way
future
innovations.
Nutraceuticals,
Год журнала:
2024,
Номер
4(4), С. 562 - 595
Опубликована: Окт. 11, 2024
The
major
constituent
of
turmeric,
curcumin,
is
a
bioactive
phenolic
compound
that
has
been
studied
for
its
potential
health
benefits
and
therapeutic
properties.
Within
this
article,
the
anti-inflammatory,
antioxidant
antithrombotic
properties
mechanisms
action
curcumin
are
thoroughly
reviewed
main
focus
shifted
to
associated
health-promoting
effects
against
inflammation-related
chronic
disorders.
An
overview
cardio-protective,
anti-tumor,
anti-diabetic,
anti-obesity,
anti-microbial
neuro–protective
reviewed,
while
relative
outcomes
obtained
from
clinical
trials
also
presented.
Emphasis
given
wound-healing
as
presented
by
several
studies
trials,
which
further
promote
application
ingredient
in
functional
products,
including
foods,
nutraceuticals,
cosmetics
drugs.
Limitations
future
perspectives
such
uses
bio-functional
discussed.
Colorectal
cancer
(CRC)
is
one
of
the
major
reasons
for
cancer-related
deaths
around
world.
Constitutive
activation
WNT
pathway,
due
to
APC
gene
mutation,
characteristic
feature
most
human
colon
tumors.
Familial
adenomatous
polyposis
(FAP)
patients
inherit
mutations
and
pose
an
absolute
risk
developing
CRC
in
their
lifetime.
The
genetically
modified
mouse
models
have
paved
way
study
various
aspects
hereditary
CRC,
including
biochemical,
molecular,
histological
aspects.
Preclinical
clinical
data
suggest
that
certain
dietary
supplements,
NSAIDs,
natural
products,
chemically
synthesized
compounds,
can
help
intercepting
incidence
progression
by
modulating
hallmarks
cancer.
In
this
review,
we
provided
a
summary
promising
synthetic
agents
demonstrated
chemopreventive
efficacy
against
FAP-mimicking
APCMin/+
model.
Biomedicines,
Год журнала:
2023,
Номер
11(6), С. 1709 - 1709
Опубликована: Июнь 14, 2023
Chemotherapy
resistance
is
still
a
serious
problem
in
the
treatment
of
most
cancers.
Many
cellular
and
molecular
mechanisms
contribute
to
both
inherent
acquired
drug
resistance.
They
include
use
unaffected
growth-signaling
pathways,
changes
tumor
microenvironment,
active
transport
medicines
out
cell.
The
antioxidant
capacity
polyphenols
their
potential
inhibit
activation
procarcinogens,
cancer
cell
proliferation,
metastasis,
angiogenesis,
as
well
promote
inhibition
or
downregulation
efflux
transporters,
have
been
linked
reduced
risk
epidemiological
studies.
Polyphenols
also
ability
alter
immunological
responses
inflammatory
cascades,
trigger
apoptosis
cells.
discovery
relationship
between
abnormal
growth
signaling
metabolic
dysfunction
cells
highlights
importance
further
investigating
effects
dietary
polyphenols,
including
boost
efficacy
chemotherapy
avoid
multidrug
(MDR).
Here,
it
summarized
what
known
regarding
effectiveness
natural
polyphenolic
compounds
counteracting
that
might
develop
drugs
result
variety
different
mechanisms.
