Biological Psychiatry,
Год журнала:
2023,
Номер
95(9), С. 839 - 848
Опубликована: Дек. 22, 2023
BACKGROUNDEpidemiological
studies
suggest
that
the
maternal
diet
quality
during
pregnancy
may
influence
risk
of
neurodevelopmental
disorders
in
offspring.
Here
we
investigated
associations
between
intake
dietary
fiber
and
ADHD
symptoms
early
childhood.METHODSWe
used
longitudinal
data
up
to
21,852
mother-father-child
trios
(49.2%
females)
from
Norwegian
Mother,
Father,
Child
Cohort
Study.
The
relationships
offspring
at
ages
three,
five,
eight
years
were
examined
using:
a)
multivariate
regression
(overall
levels
symptoms),
b)
latent
class
analysis
(subclasses
by
sex
each
age),
c)
growth
curves
(longitudinal
change
symptoms).
Covariates
polygenic
scores
child
parents,
total
energy
energy-adjusted
sugar
intake,
parental
birth
child,
socio-demographic
factors.RESULTS:
Higher
prenatal
was
associated
with
lower
symptom
all
(βage3=-0.14(95%CI
-0.18,
-0.10);
βage5=-0.14(-0.19,
-0.09);
βage8=-0.14(-0.20,
-0.09)).
Of
derived
low/middle/high
subclasses
symptoms,
belonging
middle
subclass
for
boys
girls,
high
girls
only
(middle:
ORboys
0.91(0.86-0.97)/ORgirls
0.86
(0.81-0.91);
ORgirls
0.82
(0.72-0.94)).
Maternal
rate
across
not
associated.CONCLUSIONSA
low
increase
childhood,
independently
genetic
predisposition
ADHD,
unhealthy
exposures,
factors.
Movement Disorders Clinical Practice,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
Background
The
gut‐brain
axis,
i.e.
the
bidirectional
communication
system
between
gut
and
brain,
has
become
of
central
importance
in
Parkinson
disease
(PD)
research
over
past
20
years.
Aims
We
aimed
to
describe
milestones
axis
PD
development
theories
proposing
involvement
gastrointestinal
tract
pathogenesis.
Methods
searched
PubMed
using
terms
‘gut‐brain
axis’
AND
‘Parkinson
disease’,
selected
relevant
articles
provide
foundation
for
reconstructing
an
historical
overview
PD.
Results
Mounting
evidence
from
preclinical,
clinical
post‐mortem
studies
suggests
that
a
subgroup
patients
present
with
range
prodromal
symptoms
(e.g.,
autonomic
dysfunction,
rapid
eye
movement
sleep
behaviour
disorder)
which
reflect
initial
accumulation
later
spread
pathological
α‐synuclein
rostrally
(“body‐first”
PD).
Through
neural
connections
along
may
producing
clinically
manifest
disease.
Recently,
two
mechanisms
involving
have
attracted
increasing
attention
their
role
pathogenesis
progression,
namely
perturbation
composition
microorganisms
living
(the
microbiome),
dysfunction
enteroendocrine
cells.
Conclusion
Treatments
targeting
especially
microbiome
cells
pathway,
could
potentially
slow
progression
or
even
prevent
onset.
Among
these,
pre/probiotics,
faecal
microbiota
transplantation,
glucagon‐like
peptide‐1
receptor
agonists,
entered
advanced
stages
trials
humans
shown
potential
symptomatic
disease‐modifying
effects.
Revista Argentina de Microbiología,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
pathogenesis
of
non-organic
anorexia
in
children
is
not
clear.
This
study
intends
to
analyze
intestinal
bacteria
provide
a
relevant
theoretical
basis
for
the
clinical
rational
selection
microecological
agents.
In
present
study,
with
were
included
group
and
normal
healthy
control
group.
Stool
samples
collected
bioinformatics
analysis
after
PCR
high-throughput
sequencing.
results
showed
that
Ace,
Chao,
Shannon
indexes
higher
than
those
group,
while
Simpson
index
was
lower
There
14
taxa
11
at
phylum
level,
193
180
genus
level.
dominant
level
two
groups
same,
there
16
17
ratio
percentage
abundance
Bacteroidetes
Firmicutes
(the
B/F
index)
Actinomycetes
significant
differences
genera
between
classification
LEfSe
multilevel
species
difference
influential
bacterial
Actinobacteria
At
Bacteroides,
Faecalibacterium,
Subdoligranulum,
Bifidobacterium,
Blautia,
Streptococcus,
Lachnoclostridium,
Erysipelatoclostridium
We
conclude
increase
Bacteroides
or
reduction
Bifidobacterium
related
anorexia.
Nutrients,
Год журнала:
2023,
Номер
15(3), С. 550 - 550
Опубликована: Янв. 20, 2023
Multiple
sclerosis
(MS),
a
distinct
autoimmune
neuroinflammatory
disorder,
affects
millions
of
people
worldwide,
including
Saudi
Arabia.
Changes
in
the
gut
microbiome
are
linked
to
development
neuroinflammation
via
mechanisms
that
not
fully
understood.
Prebiotics
and
probiotics
camel
milk
has
been
fermented
have
variety
health
benefits.
In
this
study,
Bacillus
amyloliquefaciens-supplemented
(BASY)
was
used
assess
its
preventive
effect
on
MS
symptoms
myelin
oligodendrocyte
glycoprotein
(MOG)-immunized
C57BL6J
mice
model.
To
end,
MOG-induced
experimental
encephalomyelitis
(EAE)
established
level
disease
index,
pathological
scores,
anti-inflammatory
markers
BASY-treated
using
macroscopic
microscopic
examinations,
qPCR
immunoblot
were
investigated.
The
results
demonstrate
BASY
significantly
reduced
EAE
increased
total
microbial
load
(2.5
fold),
improved
levels
short-chain
fatty
acids
propionic,
butyric
caproic
diseased
group.
Additionally,
myeloperoxidase
(MPO)
proinflammatory
cytokines
(IL-1β,
IL-6,
IL-17,
TNF-α)
(TGF-β)
regulated
by
treatment.
Significant
suppression
MPO
VCAM
noticed
group
(from
168
111
µM
from
34
27
pg/mL,
respectively),
comparison
treatment
expression
inflammatory
cytokines,
progression
related
transcripts,
protein
markers.
conclusion,
may
be
develop
probiotic-based
diet
promote
host
health.
cumulative
findings
study
confirm
significant
neuroprotection
They
could
also
suggest
novel
approach
MS-associated
disorders.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(18), С. 5611 - 5611
Опубликована: Сен. 21, 2024
Background:
The
gut
microbiome
plays
a
crucial
role
in
human
health,
and
recent
research
has
highlighted
its
potential
impact
on
ocular
health
through
the
gut–eye
axis.
Dysbiosis,
or
an
imbalance
microbiota,
been
implicated
various
diseases.
Methods:
A
comprehensive
literature
search
was
conducted
using
relevant
keywords
major
electronic
databases,
prioritizing
peer-reviewed
articles
published
English.
Results:
microbiota
influences
immune
modulation,
maintenance
of
blood–retinal
barrier,
production
beneficial
metabolites.
Dysbiosis
can
disrupt
these
mechanisms,
contributing
to
inflammation,
tissue
damage,
disease
progression
conditions
such
as
uveitis,
age-related
macular
degeneration,
diabetic
retinopathy,
dry
eye
disease,
glaucoma.
Therapeutic
modulation
probiotics,
prebiotics,
synbiotics,
fecal
transplantation
shows
promise
preclinical
preliminary
studies.
Conclusions:
axis
represents
dynamic
complex
interplay
between
health.
Targeting
innovative
therapeutic
strategies
holds
for
improving
prevention
management
Biological Psychiatry,
Год журнала:
2023,
Номер
95(9), С. 839 - 848
Опубликована: Дек. 22, 2023
BACKGROUNDEpidemiological
studies
suggest
that
the
maternal
diet
quality
during
pregnancy
may
influence
risk
of
neurodevelopmental
disorders
in
offspring.
Here
we
investigated
associations
between
intake
dietary
fiber
and
ADHD
symptoms
early
childhood.METHODSWe
used
longitudinal
data
up
to
21,852
mother-father-child
trios
(49.2%
females)
from
Norwegian
Mother,
Father,
Child
Cohort
Study.
The
relationships
offspring
at
ages
three,
five,
eight
years
were
examined
using:
a)
multivariate
regression
(overall
levels
symptoms),
b)
latent
class
analysis
(subclasses
by
sex
each
age),
c)
growth
curves
(longitudinal
change
symptoms).
Covariates
polygenic
scores
child
parents,
total
energy
energy-adjusted
sugar
intake,
parental
birth
child,
socio-demographic
factors.RESULTS:
Higher
prenatal
was
associated
with
lower
symptom
all
(βage3=-0.14(95%CI
-0.18,
-0.10);
βage5=-0.14(-0.19,
-0.09);
βage8=-0.14(-0.20,
-0.09)).
Of
derived
low/middle/high
subclasses
symptoms,
belonging
middle
subclass
for
boys
girls,
high
girls
only
(middle:
ORboys
0.91(0.86-0.97)/ORgirls
0.86
(0.81-0.91);
ORgirls
0.82
(0.72-0.94)).
Maternal
rate
across
not
associated.CONCLUSIONSA
low
increase
childhood,
independently
genetic
predisposition
ADHD,
unhealthy
exposures,
factors.
