Molecules,
Год журнала:
2023,
Номер
28(16), С. 6071 - 6071
Опубликована: Авг. 15, 2023
Yellow
Himalayan
raspberry
(Rubus
ellipticus
Sm.,
Rosaceae)
is
a
native
species
of
the
Indian
subcontinent,
Southern
China,
and
Philippines,
which
has
been
historically
used
as
traditional
medicine
food.
All
parts
this
plant
have
in
to
treat
respiratory
ailments,
diabetes,
gastrointestinal
disorder,
an
anti-infective
agent.
The
scientific
evaluation
revealed
richness
macronutrients,
micronutrients,
minerals
fruits,
indicating
its
potential
use
nutraceutical.
Furthermore,
found
be
rich
various
secondary
metabolites,
including
polyphenols,
flavonoids,
anthocyanins,
tannins,
terpenoids.
Ascorbic
acid,
kaempferol,
gallic
catechin
are
some
compounds
plant,
widely
discussed
for
their
health
benefits.
extracts
obtained
from
R.
shown
antioxidant,
antidiabetic,
anticancer,
anti-inflammatory,
nephroprotective,
antipyretic,
anticonvulsant,
activities
investigated
through
different
study
models.
These
findings
literature
validated
widespread
uses
fruits
folk
medicinal
systems
consumption
nutritious
wild
fruit
by
local
communities.
In
conclusion,
holds
strong
development
It
can
also
improve
nutritional
status
villagers
uplift
economy
if
properly
utilized
marketed.
Biomolecules,
Год журнала:
2024,
Номер
14(2), С. 234 - 234
Опубликована: Фев. 17, 2024
Recent
studies
have
demonstrated
that
the
interaction
of
dietary
constituents
with
taste
and
olfactory
receptors
nociceptors
expressed
in
oral
cavity,
nasal
cavity
gastrointestinal
tract
regulate
homeostasis
through
activation
neuroendocrine
system.
Polyphenols,
which
8000
been
identified
to
date,
represent
greatest
diversity
secondary
metabolites
plants,
most
are
bitter
some
them
astringent.
Epidemiological
shown
polyphenol
intake
contributes
maintaining
improving
cardiovascular,
cognitive
sensory
health.
However,
because
polyphenols
very
low
bioavailability,
mechanisms
their
beneficial
effects
unknown.
In
this
review,
we
focused
on
from
perspective
nutrition,
summarized
results
previous
relationship
bioregulation
discussed
future
potential.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 692 - 692
Опубликована: Май 27, 2024
There
are
a
wide
variety
of
phytochemicals
collectively
known
as
polyphenols.
Their
structural
diversity
results
in
broad
range
characteristics
and
biological
effects.
Polyphenols
can
be
found
foods
drinks,
including
fruits,
cereals,
tea,
coffee.
Studies
both
vitro
vivo,
well
clinical
trials,
have
shown
that
they
possess
potent
antioxidant
activities,
numerous
therapeutic
effects,
health
advantages.
Dietary
polyphenols
demonstrated
the
potential
to
prevent
many
problems,
obesity,
atherosclerosis,
high
blood
sugar,
diabetes,
hypertension,
cancer,
neurological
diseases.
In
this
paper,
protective
effects
mechanisms
behind
them
investigated
detail,
citing
most
recent
available
literature.
This
review
aims
provide
comprehensive
overview
current
knowledge
on
role
preventing
managing
chronic
The
cited
publications
derived
from
vitro,
human-based
studies
trials.
A
more
complete
understanding
these
naturally
occurring
metabolites
will
pave
way
for
development
novel
polyphenol-rich
diet
drug
programs.
This,
turn,
provides
further
evidence
their
benefits.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 26, 2023
Phyllanthus
emblica
Linn,
a
prominent
member
of
the
euphorbiaceae
family,
exhibits
extensive
distribution
across
multitude
tropical
and
subtropical
nations.
Referred
to
as
“Balakka”
in
Indonesia,
this
plant
assumes
various
names
regions,
such
“kimalaka,”
“balakka,”
“metengo,”
“malaka,”
“kemloko”
North
Sumatra,
Ternate,
Sundanese,
Java
respectively.
thrives
locales
like
Malaysia,
Thailand,
while
also
making
its
presence
felt
regions
India,
China,
Uzbekistan,
Sri
Lanka.
The
fruits
Balakka
are
enriched
with
bioactive
constituents
recognized
for
their
wide-ranging
benefits,
including
antioxidant,
anti-aging,
anti-cholesterol,
anti-diabetic,
immunomodulatory,
antipyretic,
analgesic,
anti-inflammatory,
chemoprotective,
hepatoprotective,
cardioprotective,
antimutagenic,
antimicrobial
properties.
Comprising
spectrum
phenolic
compounds
(such
tannins,
acids,
flavonoids),
alkaloids,
phytosterols,
terpenoids,
organic
amino
vitamins,
components
Malacca
fruit
offer
diverse
array
health-promoting
attributes.
In
light
these
insights,
review
aims
comprehensively
examine
pharmacological
activities
associated
P.
delve
into
intricate
composition
phytochemical
constituents.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Март 14, 2023
Osteoarthritis
(OA)
is
a
typical
joint
disease
associated
with
chronic
inflammation.
The
nuclear
factor-kappaB
(NF-κB)
pathway
plays
an
important
role
in
inflammatory
activity
and
inhibiting
NF-κB-mediated
inflammation
can
be
potential
strategy
for
treating
OA.
Flavonoids
are
class
of
naturally
occurring
polyphenols
anti-inflammatory
properties.
Structurally,
natural
flavonoids
divided
into
several
sub-groups,
including
flavonols,
flavones,
flavanols/catechins,
flavanones,
anthocyanins,
isoflavones.
Increasing
evidence
demonstrates
that
exhibit
protective
against
the
pathological
changes
OA
by
NF-κB
signaling
pathway.
Potentially,
may
suppress
signaling-mediated
responses,
ECM
degradation,
chondrocyte
apoptosis.
different
biological
actions
chondrocytes
might
differentially
substituted
groups
on
structures.
In
this
review,
efficacy
action
mechanism
development
discussed
targeting
could
become
useful
inhibitors
therapeutic
management
Molecules,
Год журнала:
2023,
Номер
28(1), С. 426 - 426
Опубликована: Янв. 3, 2023
Stereoselective
synthesis
has
been
emerging
as
a
resourceful
tool
because
it
enables
the
obtaining
of
compounds
with
biological
interest
and
high
enantiomeric
purity.
Flavonoids
are
natural
products
several
activities.
Owing
to
their
potential
aiming
achieve
enantiomerically
pure
forms,
methodologies
stereoselective
have
implemented.
Those
approaches
encompass
chalcone
epoxidation,
Sharpless
asymmetric
dihydroxylation,
Mitsunobu
reaction,
cycloaddition
1,4-benzoquinone.
Chiral
auxiliaries,
organo-,
organometallic,
biocatalysis,
well
chiral
pool
approach
were
also
employed
goal
bioactive
flavonoids
ratio.
Additionally,
employment
Diels–Alder
reaction
based
on
stereodivergent
racemic
mixture
strategy
or
using
catalyst
complexes
synthesise
enantiomers
was
reported.
Furthermore,
biomimetic
pathways
displayed
another
illustrated
by
coupling
2-hydroxychalcones
driven
visible
light.
Recently,
an
transfer
hydrogen-dynamic
kinetic
resolution
applied
(R,R)-cis-alcohols
which,
in
turn,
would
be
used
building
blocks
for
flavonoids.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 836 - 836
Опубликована: Июль 11, 2024
Polyphenols
are
natural
bioactives
occurring
in
medicinal
and
aromatic
plants
food
beverages
of
plant
origin.
Compared
with
conventional
therapies,
plant-derived
phytochemicals
more
affordable
accessible
have
no
toxic
side
effects.
Thus,
pharmaceutical
research
is
increasingly
inclined
to
discover
study
new
innovative
molecules
for
the
treatment
several
chronic
human
diseases,
like
type
2
diabetes
mellitus
(T2DM)
osteoporosis.
These
pathological
conditions
characterized
by
a
inflammatory
state
persistent
oxidative
stress,
which
interconnected
lead
development
worsening
these
two
health
disorders.
Oral
nano
delivery
strategies
been
used
improve
bioavailability
polyphenols
allow
exert
their
antioxidant,
anti-inflammatory,
anti-diabetic,
pro-osteogenic
biological
activities
vivo
experimental
models
patients.
commonly
formulations
nutraceuticals,
can
counteract
detrimental
effects
T2DM
osteoporosis
pathologies.
This
review
describes
that
protective
against
through
modulation
specific
molecular
markers
pathways.
could
be
as
adjuvants,
combination
synthetic
drugs,
future
develop
therapeutic
Foods,
Год журнала:
2024,
Номер
13(15), С. 2441 - 2441
Опубликована: Авг. 2, 2024
Aging
is
a
natural
and
irreversible
process,
affecting
living
organisms
by
negatively
impacting
the
tissues'
cells'
morphology
functionality
consequently
being
responsible
for
aging-related
diseases.
Taking
into
account
actual
preoccupations
of
both
consumers
researchers,
healthy
anti-aging
alternatives
are
intensively
studied
in
order
to
address
such
concerns.
Due
their
functional
features,
plant
flavonoids
can
be
considered
valuable
nutraceuticals.
This
paper
highlights
possibilities
use
extracted
from
various
plants
potential
on
skin,
brain,
heart.
Moreover,
anticarcinogenic,
anti-inflammatory,
anti-diabetic
properties
summarized,
along
with
senescence-associated
mechanisms.
Both
nutraceutical
cosmeceutical
fields
continuously
developing
originating
promising
candidates
obtain
products.
Thus,
bioactive
compounds'
extraction
subsequent
involvement
innovative
product
manufacturing
must
carefully
performed
while
aware
intrinsic
extrinsic
factors
that
may
affect
phytochemicals'
structures,
bioavailability,
health
effects.
