Yellow Himalayan Raspberry (Rubus ellipticus Sm.): Ethnomedicinal, Nutraceutical, and Pharmacological Aspects DOI Creative Commons
Ananda Lamichhane, Gopal Lamichhane, Hari Prasad Devkota

и другие.

Molecules, Год журнала: 2023, Номер 28(16), С. 6071 - 6071

Опубликована: Авг. 15, 2023

Yellow Himalayan raspberry (Rubus ellipticus Sm., Rosaceae) is a native species of the Indian subcontinent, Southern China, and Philippines, which has been historically used as traditional medicine food. All parts this plant have in to treat respiratory ailments, diabetes, gastrointestinal disorder, an anti-infective agent. The scientific evaluation revealed richness macronutrients, micronutrients, minerals fruits, indicating its potential use nutraceutical. Furthermore, found be rich various secondary metabolites, including polyphenols, flavonoids, anthocyanins, tannins, terpenoids. Ascorbic acid, kaempferol, gallic catechin are some compounds plant, widely discussed for their health benefits. extracts obtained from R. shown antioxidant, antidiabetic, anticancer, anti-inflammatory, nephroprotective, antipyretic, anticonvulsant, activities investigated through different study models. These findings literature validated widespread uses fruits folk medicinal systems consumption nutritious wild fruit by local communities. In conclusion, holds strong development It can also improve nutritional status villagers uplift economy if properly utilized marketed.

Язык: Английский

Chemical compositions, health benefits, safety assessment, and industrial applications of wampee (Clausena lansium (Lour.) Skeels): A comprehensive review DOI

L. Ding,

Xiaoze Liu,

Tao Fei

и другие.

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104922 - 104922

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Effects of luteolin on sepsis: A comprehensive systematic review DOI
Mahdi Vajdi, Arash Karimi, Mozhdeh Karimi

и другие.

Phytomedicine, Год журнала: 2023, Номер 113, С. 154734 - 154734

Опубликована: Фев. 26, 2023

Язык: Английский

Процитировано

21
Natural products with potential hypoglycemic activity in T2DM: 2019–2023 DOI
Zhang Fei,

Yang Xu,

Guoyu Zhang

и другие.

Phytochemistry, Год журнала: 2024, Номер 223, С. 114130 - 114130

Опубликована: Май 5, 2024

Язык: Английский

Процитировано

7
Relationship between Flavonoid Chemical Structures and Their Antioxidant Capacity in Preventing Polycyclic Aromatic Hydrocarbons Formation in Heated Meat Model System DOI Creative Commons
Thi Thu Huong Huynh, Wanwisa Wongmaneepratip, Kanithaporn Vangnai

и другие.

Foods, Год журнала: 2024, Номер 13(7), С. 1002 - 1002

Опубликована: Март 25, 2024

The relationship between the chemical structures of six flavonoids and their abilities to inhibit formation polycyclic aromatic hydrocarbons (PAHs) in a heated meat model system was investigated. PAH8 forming samples analyzed by using QuEChERS coupled GC-MS. Inhibitory effects PAHs were myricetin (72.1%) > morin (55.7%) quercetin (57.3%) kaempferol (49.9%) rutin (32.7%) taxifolin (30.2%). antioxidant activities these flavonoids, assessed through (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging activity assay (DPPH), [2,2′-azinobis (3-ethylbenzothiazoline-6-sulphonic acid)] (ABTS) ferric ion reducing power (FRAP) assays, exhibited significant negative correlation with PAH reduction. Notably, that contained three hydroxyl groups on B-ring, along 2,3-double bond conjugation 4-keto moiety C-ring, demonstrated strong properties abilities, which significantly contributed ability formation. However, taxifolin, substituted at C-3 position decreased inhibitory activity. ABTS proved most effective demonstrating flavonoid capacity systems. Thus, inhibition can be achieved dietary according structures.

Язык: Английский

Процитировано

6
Regulation of bone homeostasis by traditional Chinese medicine active scaffolds and enhancement for the osteoporosis bone regeneration DOI
Xi Wang, Pengfei Tang,

Kun Yang

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118141 - 118141

Опубликована: Апрель 2, 2024

Язык: Английский

Процитировано

6
Virtual screening, ADME prediction, drug-likeness, and molecular docking analysis of Fagonia indica chemical constituents against antidiabetic targets DOI

Rabia Riaz,

Shagufta Parveen, Nusrat Shafiq

и другие.

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Июль 16, 2024

Язык: Английский

Процитировано

6
Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review DOI Creative Commons
Erdan Luo,

Hai‐Mei Jiang,

Wei Chen

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 13

Опубликована: Янв. 9, 2023

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women reproductive age and features complex pathological symptoms mechanisms. Existing medical treatments have, to some extent, alleviated deterioration PCOS. However, these strategies only temporarily control symptoms, with a few side effects no preventive effect. Phytochemicals extracted from medicinal herbs plants are vital for discovering novel drugs. In recent years, many kinds research have proven that phytochemicals isolated traditional Chinese medicine (TCM) show significant potential preventing, alleviating, treating Nevertheless, compared abundance experimental literature minimal specific-topic reviews related PCOS, there lack systematic summarize advancements this promising field. Under background, we systematically document progress bioactive TCM including flavonoids, polyphenols, alkaloids. According literature, valuable demonstrated therapeutic on PCOS supported by vivo vitro experiments, mainly depending anti-inflammatory, antioxidation, improvement hormone disorder insulin resistance (IR), alleviation hyperinsulinemia. Based current progress, future directions should emphasize 1) exploring potentially mediate bone metabolism treatment PCOS; 2) improving unsatisfactory bioavailability using advanced drug delivery systems such as nanoparticles antibody-conjugated drugs, well chemical modification; 3) conducting in-depth pathogenesis impact gut microbiota its metabolites evolution 4) revealing pharmacological at genetic level; 5) hypothetical unprecedented functions regulating serving proteolysis-targeting chimeras molecular glues small molecule brief, review aims provide detailed mechanisms hopefully practical reliable insight into clinical applications concerning

Язык: Английский

Процитировано

16
Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World DOI Open Access

Rachid Kacemi,

María G. Campos

Nutrients, Год журнала: 2023, Номер 15(10), С. 2413 - 2413

Опубликована: Май 22, 2023

The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved the genesis development of many world-scale public health burdens, such as metabolic cardiovascular diseases. In recent years, bee pollen emerging scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix being extensively studied, has proven very rich well-balanced nutrient pool. this work, we reviewed available evidence interest source. We mainly focused richness nutrients its possible roles main pathophysiological processes that are directly linked imbalances. scoping review analyzed scientific works published last four focusing clearest inferences perspectives translate cumulated experimental preclinical into clinically relevant insights. promising uses for malnutrition, digestive health, disorders, other bioactivities could helpful readjust homeostasis (as it also true case anti-inflammatory or anti-oxidant needs), well benefits diseases, were identified. knowledge gaps identified, along with practical challenges hinder establishment fructification these uses. A complete data collection made major range botanical species allows more robust clinical information.

Язык: Английский

Процитировано

15
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells DOI Creative Commons
Xiongxiong Liu, Ting Zhao, Zheng Shi

и другие.

Molecules, Год журнала: 2023, Номер 28(13), С. 4947 - 4947

Опубликована: Июнь 23, 2023

Non-small cell lung cancer (NSCLC) is one of the leading killers. Apigenin (Api) and Naringenin (Nar) are natural bioactive substances obtained in various vegetables fruits, possessing anti-tumor effects across multiple studies. This study investigated latent synergistic antiproliferative functions Api Nar A549 H1299 NSCLC cells. Cell viability was determined after incubating with different concentrations Api, Nar, or combination (CoAN) for 24 h. Analysis using CompuSyn software revealed that CI value each combined dose < 1, depicting two drugs had a inhibitory effect. The CoAN (A:N = 3:2) group lowest selected subsequent experiments. IC50 used to determine cycle, expression ratio Bax Bcl2, Caspase 3 activity, mitochondrial function assess oxidative stress apoptosis. results established treatment caused significant cytotoxicity cycle arrest at G2/M phases. Furthermore, significantly enhanced mitochondria dysfunction, elevated stress, activated apoptotic pathway versus alone groups. Thus, chemotherapy approach promising deserves further research.

Язык: Английский

Процитировано

15
Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication DOI
Guilherme S. Caleffi, Alice dos Santos Rosa, Luana G. de Souza

и другие.

Journal of Natural Products, Год журнала: 2023, Номер 86(6), С. 1536 - 1549

Опубликована: Май 31, 2023

Aurones are a small subgroup of flavonoids in which the basic C6–C3–C6 skeleton is arranged as (Z)-2-benzylidenebenzofuran-3(2H)-one. These compounds structural isomers flavones and flavonols, natural products reported potent inhibitors SARS-CoV-2 replication. Herein, we report design, synthesis, anti-SARS-CoV-2 activity series 25 aurones bearing different oxygenated groups (OH, OCH3, OCH2OCH3, OCH2O, OCF2H, OCH2C6H4R) at A- and/or B-rings using cell-based screening assays. We observed that 12 exhibit EC50 < 3 μM (8e, 8h, 8j, 8k, 8l, 8m, 8p, 8q, 8r, 8w, 8x, 8y), five presented 1 (8h, 8w) without evident cytotoxic effect Calu-3 cells. The substitution B-ring with OCF2H seems beneficial for antiviral activity, while corresponding phenolic derivatives showed significant decrease activity. most compound series, aurone 8q (EC50 = 0.4 μM, SI 2441.3), 2 to times more effective than polyphenolic myricetin (2) baicalein (1), respectively. Investigation active 3CLpro based on molecular dynamic calculations suggested these should detach from site 3CLpro, and, probably, they could bind another protein target (either receptor or enzyme).

Язык: Английский

Процитировано

14