Association of oxidative balance score with sleep quality: NHANES 2007–2014

Journal of Affective Disorders, Год журнала: 2023, Номер 339, С. 435 - 442

Опубликована: Июль 11, 2023

Oxidative stress is correlated with sleep quality. A common tool for evaluating dietary and lifestyle exposures to oxidative the Balance Score (OBS), higher OBS suggesting more substantial antioxidant exposures. The relationship between quality unclear. Investigating association was purpose of this study. To figure out quality, we utilized weighted linear models logistic regression. Adjusted were also examined. 6300 participants who took part in National Health Nutrition Examination Survey (NHANES) from 2007 2014 recruited. negatively associated disorder (OR: 0.97; 95 % CI: 0.94–0.99), positively duration (MD: 0.02; 95%CI: 0.01–0.03). Within range > 24, each unit increase will result a 40 reduction disorder, 26 increasement after adjustment (all P trend <0.05). Dietary components closely related independently. prominent female population under 50 years age. After stratification by education level, persisted. This research cross-sectional design, it not possible deduce causality. Diet might influence modulating balance. Antioxidant diets lifestyles important reducing problems our study provided new ideas improving

Язык: Английский

---

Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology

Molecules, Год журнала: 2025, Номер 30(1), С. 167 - 167

Опубликована: Янв. 4, 2025

Caffeine has recently attracted attention as a potential remedy for hair loss. In the present review, we look into molecule’s possible mechanisms of action and pharmacodynamics. At molecular level, it appears that physiological effects caffeine are mainly due to interaction with adenosine pathways which leads an increase in cAMP level stimulation metabolic activity follicle. Moreover, also acts antioxidant may prevent degenerative processes. While intact stratum corneum seems virtually impenetrable range physical chemical methods have been proposed facilitate its penetration, follicles seem be both main entry route skin target structures at same time. readily forms bonds water other molecules influence bioavailability should taken account when engineering future products. The results clinical studies published so far promising; however, majority caffeine-based loss products offer very low evidence considerable flaws study designs. Nevertheless, ability enter accumulate combined available trials indicate could indeed prove effective safe option management

Язык: Английский

---

Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

Polymers, Год журнала: 2023, Номер 15(8), С. 1962 - 1962

Опубликована: Апрель 20, 2023

Ascorbic acid (AA) and caffeine (CAFF) work to protect cells from ultraviolet (UV) radiation slow down the photoaging process of skin. However, cosmetic application AA CAFF is limited due poor penetration across skin rapid oxidation AA. The aim this study was design evaluate dermal delivery dual antioxidants utilizing microneedles (MNs) loaded with niosomes. niosomal nanovesicles were prepared using thin film method had particle sizes ranging 130.6–411.2 nm a negative Zeta potential around −35 mV. formulation then combined polyvinylpyrrolidone (PVP) polyethylene glycol 400 (PEG 400) create an aqueous polymer solution. best deposition achieved containing 5% PEG (M3) PVP. Furthermore, role as in preventing cancer formation has been well-established. Here we validated antioxidant properties ascorbic novel referred M3 by testing its ability prevent H2O2-indued cell damage apoptosis MCF-7 breast cells. Results showed that able shield H2O2 induced at concentrations below 2.1 µg/mL for 1.05 CAFF, also exhibited anticancer effects higher 210 105 µg/mL. formulations stable two months room temperature terms moisture drug content. use MNs carriers could be promising approach hydrophilic drugs like CAFF.

Язык: Английский

---

MOF–Thermogel Composites for Differentiated and Sustained Dual Drug Delivery

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(10), С. 5724 - 5736

Опубликована: Сен. 20, 2023

In recent years, multidrug therapy has gained increasing popularity due to the possibility of achieving synergistic drug action and sequential delivery different medical payloads for enhanced treatment efficacy. While a number composite material release platforms have been developed, few combine bottom-up design versatility metal-organic frameworks (MOFs) tailor behavior, with convenience temperature-responsive hydrogels (or thermogels) in their unique ease administration formulation. Yet, despite potential, MOF-thermogel composites largely overlooked simultaneous delivery. Herein, we report first systematic study common MOFs (UiO-66, MIL-53(Al), MIL-100(Fe), MOF-808) pore sizes, geometries, hydrophobicities ability achieve dual when embedded within PEG-containing thermogel matrices. After establishing that exert small influences on rheological properties thermogels penetration polymers into MOF pores solution, profiles ibuprofen caffeine as model hydrophobic hydrophilic drugs, respectively, from were investigated. Through these studies, elucidated important role matching between loaded drugs order component distinctly influence kinetics. These findings enabled us identify viable containing UiO-66 showed vastly kinetics caffeine, enabling temporally differentiated yet sustained be achieved. Finally, shown noncytotoxic vitro, paving way underexploited materials find possible clinical applications therapy.

Язык: Английский

---

Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12003 - 12003

Опубликована: Ноя. 8, 2024

Natural caffeine is found in many plants, including coffee beans, cacao and tea leaves. Around the world, beverages, coffee, tea, energy drinks, some soft have this natural compound. This paper reviewed results of meta-studies on caffeine's effects chronic diseases. Of importance, shown that regularly drinking or caffeinated significantly reduces risk developing Alzheimer's disease, epilepsy, Parkinson's disease. Based health supplements caffeine, review summarizes various aspects related to application its pharmacokinetics, functional benefits such as central nervous system. The importance use alleviating treating cancer, diabetes, eye diseases, autoimmune cardiovascular diseases also discussed. Overall, consuming daily drinks containing antioxidant neuroprotective properties, prevents progressive neurodegenerative Parkinson's. Furthermore, effectively deliver body, recently developed nanoformulations using for instance, nanoparticles, liposomes, etc., are summarized along with regulatory safety considerations caffeine. U.S. Department Agriculture (USDA) Food Drug Administration (FDA) recommended healthy adults consume up 400 mg per day 5~6 mg/kg body weight. Since a cup contains, average, 100 150 1 3 cups may help prevent interesting important areas research applications human health.

Язык: Английский

---

Caffeine, vanillin and their combination modulate purinergic enzyme activities, mRNA expressions of some synapticsentry proteins and histomorphological status of hippocampal tissue in aluminum chloride-induced neurotoxicity in rats

Pharmacological Research - Natural Products, Год журнала: 2025, Номер unknown, С. 100201 - 100201

Опубликована: Март 1, 2025

Язык: Английский

---

The Role of Xenobiotic Caffeine on Cardiovascular Health: Promises and Challenges

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 51 - 51

Опубликована: Март 31, 2025

Cardiovascular diseases (CVDs) represent a leading cause of premature mortality and disability worldwide, with their incidence expected to rise, potentially reaching 24 million deaths per year by 2030. These multifactorial diseases, including hypertension, coronary artery disease, arrhythmia, heart failure, are often linked metabolic disturbances such as diabetes, oxidative stress, endothelial dysfunction, inflammation. Natural compounds, caffeine, have been explored for potential therapeutic effects on CVDs. Caffeine, found in coffee, tea, cocoa, various energy drinks, is widely consumed psychoactive compound noted analgesic anti-inflammatory properties. Despite its long history use, caffeine’s impact cardiovascular health remains controversial, both beneficial harmful reported. This review examines the current literature caffeine (CVDs), an emphasis preclinical clinical studies, pharmacokinetic properties, molecular mechanisms it modulates. There evidence that moderate intake can be some CVDs, while other dyslipidemia, collected so far suggests could detrimental since increases total cholesterol levels. But variability dosage, patterns, individual factors (such genetics diet) complicates reliability results. Additionally, challenges related dose standardization absence consistent trial designs hinder full utilization CVD treatment. Nonetheless, appears safe individuals without significant conditions. Future research should aim well-designed studies precise patient cohorts standardized methodologies better assess role management.

Язык: Английский

---

Chemical composition and anti-radical properties of coffee cherry cultivated in Mediterranean climate

Food Bioscience, Год журнала: 2023, Номер 56, С. 103349 - 103349

Опубликована: Ноя. 19, 2023

Язык: Английский

---

Applying HS-SPME-GC-MS combined with PTR-TOF-MS to analyze the volatile compounds in coffee husks of Coffea arabica with different primary processing treatments in Yunnan

LWT, Год журнала: 2023, Номер 191, С. 115675 - 115675

Опубликована: Дек. 21, 2023

Primary processing treatments are crucial to the flavor profile of coffee beans, which create precursors basis in husks and diffuse into with satisfying outcomes. In this study, eleven Coffea arabica different primary (sun exposure, washing honey treatment) from three latitudes Yunnan were investigated by combination HS-SPME-GC-MS PTR-TOF-MS. A total 114 volatile organic compounds (VOCs) 77 masses identified. The characteristic octanoic acid (S1) methyl linoleate (S11) sun-exposed, phenethyl alcohol (F4), salicylate (F7), 3,5-dimethylbenzaldehyde (F9) phytone (T9) washed n-hexadecanoic (S9) honey-treated recognized ions at m/z 33.032, 68.049, 83.049, 67.054, 57.034, 41.030 49.010, respectively. This study demonstrated feasibility complementarity PTR-TOF-MS rapid identification VOCs husks. Meanwhile, antioxidant capacities 11 evaluated vitro, sun-exposed samples exhibited most promising potency, (S11), linolenate (S13), ethyl (S14), (S16), linalool (T1), citronellol (T2) caffeine (J3) contributed mainly capacities.

Язык: Английский

---

Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling

npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)

Опубликована: Июнь 29, 2024

Abstract Many studies have reported metabolomic analysis of different bio-specimens from Parkinson’s disease (PD) patients. However, inconsistencies in metabolite concentration changes make it difficult to draw conclusions as the role metabolism occurrence or development disease. We reviewed literature on PD From 74 that passed quality control metrics, 928 metabolites were identified with significant patients, but only 190 replicated same more than one study. Of these metabolites, 60 exclusively increased, such 3-methoxytyrosine and glycine, 54 decreased, pantothenic acid caffeine, 76 inconsistently changed versus subjects, ornithine tyrosine. A genome-scale metabolic model corresponding map linking most enabled a better understanding dysfunctional pathways prediction additional potential markers consistent target future studies.

Язык: Английский

---