Association of oxidative balance score with sleep quality: NHANES 2007–2014

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 339, P. 435 - 442

Published: July 11, 2023

Oxidative stress is correlated with sleep quality. A common tool for evaluating dietary and lifestyle exposures to oxidative the Balance Score (OBS), higher OBS suggesting more substantial antioxidant exposures. The relationship between quality unclear. Investigating association was purpose of this study. To figure out quality, we utilized weighted linear models logistic regression. Adjusted were also examined. 6300 participants who took part in National Health Nutrition Examination Survey (NHANES) from 2007 2014 recruited. negatively associated disorder (OR: 0.97; 95 % CI: 0.94–0.99), positively duration (MD: 0.02; 95%CI: 0.01–0.03). Within range > 24, each unit increase will result a 40 reduction disorder, 26 increasement after adjustment (all P trend <0.05). Dietary components closely related independently. prominent female population under 50 years age. After stratification by education level, persisted. This research cross-sectional design, it not possible deduce causality. Diet might influence modulating balance. Antioxidant diets lifestyles important reducing problems our study provided new ideas improving

Language: Английский

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The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386

Published: Jan. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Language: Английский

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Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 167 - 167

Published: Jan. 4, 2025

Caffeine has recently attracted attention as a potential remedy for hair loss. In the present review, we look into molecule’s possible mechanisms of action and pharmacodynamics. At molecular level, it appears that physiological effects caffeine are mainly due to interaction with adenosine pathways which leads an increase in cAMP level stimulation metabolic activity follicle. Moreover, also acts antioxidant may prevent degenerative processes. While intact stratum corneum seems virtually impenetrable range physical chemical methods have been proposed facilitate its penetration, follicles seem be both main entry route skin target structures at same time. readily forms bonds water other molecules influence bioavailability should taken account when engineering future products. The results clinical studies published so far promising; however, majority caffeine-based loss products offer very low evidence considerable flaws study designs. Nevertheless, ability enter accumulate combined available trials indicate could indeed prove effective safe option management

Language: Английский

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MOF–Thermogel Composites for Differentiated and Sustained Dual Drug Delivery

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(10), P. 5724 - 5736

Published: Sept. 20, 2023

In recent years, multidrug therapy has gained increasing popularity due to the possibility of achieving synergistic drug action and sequential delivery different medical payloads for enhanced treatment efficacy. While a number composite material release platforms have been developed, few combine bottom-up design versatility metal-organic frameworks (MOFs) tailor behavior, with convenience temperature-responsive hydrogels (or thermogels) in their unique ease administration formulation. Yet, despite potential, MOF-thermogel composites largely overlooked simultaneous delivery. Herein, we report first systematic study common MOFs (UiO-66, MIL-53(Al), MIL-100(Fe), MOF-808) pore sizes, geometries, hydrophobicities ability achieve dual when embedded within PEG-containing thermogel matrices. After establishing that exert small influences on rheological properties thermogels penetration polymers into MOF pores solution, profiles ibuprofen caffeine as model hydrophobic hydrophilic drugs, respectively, from were investigated. Through these studies, elucidated important role matching between loaded drugs order component distinctly influence kinetics. These findings enabled us identify viable containing UiO-66 showed vastly kinetics caffeine, enabling temporally differentiated yet sustained be achieved. Finally, shown noncytotoxic vitro, paving way underexploited materials find possible clinical applications therapy.

Language: Английский

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Applying HS-SPME-GC-MS combined with PTR-TOF-MS to analyze the volatile compounds in coffee husks of Coffea arabica with different primary processing treatments in Yunnan

LWT, Journal Year: 2023, Volume and Issue: 191, P. 115675 - 115675

Published: Dec. 21, 2023

Primary processing treatments are crucial to the flavor profile of coffee beans, which create precursors basis in husks and diffuse into with satisfying outcomes. In this study, eleven Coffea arabica different primary (sun exposure, washing honey treatment) from three latitudes Yunnan were investigated by combination HS-SPME-GC-MS PTR-TOF-MS. A total 114 volatile organic compounds (VOCs) 77 masses identified. The characteristic octanoic acid (S1) methyl linoleate (S11) sun-exposed, phenethyl alcohol (F4), salicylate (F7), 3,5-dimethylbenzaldehyde (F9) phytone (T9) washed n-hexadecanoic (S9) honey-treated recognized ions at m/z 33.032, 68.049, 83.049, 67.054, 57.034, 41.030 49.010, respectively. This study demonstrated feasibility complementarity PTR-TOF-MS rapid identification VOCs husks. Meanwhile, antioxidant capacities 11 evaluated vitro, sun-exposed samples exhibited most promising potency, (S11), linolenate (S13), ethyl (S14), (S16), linalool (T1), citronellol (T2) caffeine (J3) contributed mainly capacities.

Language: Английский

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Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

Polymers, Journal Year: 2023, Volume and Issue: 15(8), P. 1962 - 1962

Published: April 20, 2023

Ascorbic acid (AA) and caffeine (CAFF) work to protect cells from ultraviolet (UV) radiation slow down the photoaging process of skin. However, cosmetic application AA CAFF is limited due poor penetration across skin rapid oxidation AA. The aim this study was design evaluate dermal delivery dual antioxidants utilizing microneedles (MNs) loaded with niosomes. niosomal nanovesicles were prepared using thin film method had particle sizes ranging 130.6–411.2 nm a negative Zeta potential around −35 mV. formulation then combined polyvinylpyrrolidone (PVP) polyethylene glycol 400 (PEG 400) create an aqueous polymer solution. best deposition achieved containing 5% PEG (M3) PVP. Furthermore, role as in preventing cancer formation has been well-established. Here we validated antioxidant properties ascorbic novel referred M3 by testing its ability prevent H2O2-indued cell damage apoptosis MCF-7 breast cells. Results showed that able shield H2O2 induced at concentrations below 2.1 µg/mL for 1.05 CAFF, also exhibited anticancer effects higher 210 105 µg/mL. formulations stable two months room temperature terms moisture drug content. use MNs carriers could be promising approach hydrophilic drugs like CAFF.

Language: Английский

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Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 29, 2024

Abstract Many studies have reported metabolomic analysis of different bio-specimens from Parkinson’s disease (PD) patients. However, inconsistencies in metabolite concentration changes make it difficult to draw conclusions as the role metabolism occurrence or development disease. We reviewed literature on PD From 74 that passed quality control metrics, 928 metabolites were identified with significant patients, but only 190 replicated same more than one study. Of these metabolites, 60 exclusively increased, such 3-methoxytyrosine and glycine, 54 decreased, pantothenic acid caffeine, 76 inconsistently changed versus subjects, ornithine tyrosine. A genome-scale metabolic model corresponding map linking most enabled a better understanding dysfunctional pathways prediction additional potential markers consistent target future studies.

Language: Английский

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Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12003 - 12003

Published: Nov. 8, 2024

Natural caffeine is found in many plants, including coffee beans, cacao and tea leaves. Around the world, beverages, coffee, tea, energy drinks, some soft have this natural compound. This paper reviewed results of meta-studies on caffeine's effects chronic diseases. Of importance, shown that regularly drinking or caffeinated significantly reduces risk developing Alzheimer's disease, epilepsy, Parkinson's disease. Based health supplements caffeine, review summarizes various aspects related to application its pharmacokinetics, functional benefits such as central nervous system. The importance use alleviating treating cancer, diabetes, eye diseases, autoimmune cardiovascular diseases also discussed. Overall, consuming daily drinks containing antioxidant neuroprotective properties, prevents progressive neurodegenerative Parkinson's. Furthermore, effectively deliver body, recently developed nanoformulations using for instance, nanoparticles, liposomes, etc., are summarized along with regulatory safety considerations caffeine. U.S. Department Agriculture (USDA) Food Drug Administration (FDA) recommended healthy adults consume up 400 mg per day 5~6 mg/kg body weight. Since a cup contains, average, 100 150 1 3 cups may help prevent interesting important areas research applications human health.

Language: Английский

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Chemical composition and anti-radical properties of coffee cherry cultivated in Mediterranean climate

Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103349 - 103349

Published: Nov. 19, 2023

Language: Английский

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Protective Effects of Early Caffeine Administration in Hyperoxia-Induced Neurotoxicity in the Juvenile Rat

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 295 - 295

Published: Jan. 28, 2023

High-risk preterm infants are affected by a higher incidence of cognitive developmental deficits due to the unavoidable risk factor oxygen toxicity. Caffeine is known have protective effect in preventing bronchopulmonary dysplasia associated with improved neurologic outcomes, although very early initiation therapy controversial. In this study, we used newborn rats an injury model test hypothesis that near-birth caffeine administration modulates neuronal maturation and differentiation hippocampus developing brain. For purpose, Wistar were exposed 21% or 80% on day birth for 3 5 days treated vehicle (10 mg/kg/48 h). Postnatal exposure resulted drastic reduction mediators radial glia, mitotic/postmitotic neurons, impaired cell-cycle regulation, predominantly persistent even after recovery room air until postnatal 15. Systemic significantly counteracted effects insult hippocampus. Interestingly, under normoxia, inhibited transcription maturing mature neurons. The modulated hyperoxia-induced decreased neurogenesis showed neuroprotective properties neonatal rat toxicity model.

Language: Английский

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