Published: Jan. 1, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9605 - 9605
Published: May 31, 2023
S100B is a calcium-binding protein mainly concentrated in astrocytes the nervous system. Its levels biological fluids are recognized as reliable biomarker of active neural distress, and more recently, mounting evidence points to Damage-Associated Molecular Pattern molecule, which, at high concentration, triggers tissue reactions damage. and/or distribution patients experimental models different disorders, for which used biomarker, directly related progress disease. In addition, diseases such Alzheimer’s Parkinson’s diseases, amyotrophic lateral sclerosis, multiple traumatic vascular acute injury, epilepsy, inflammatory bowel disease, alteration correlates with occurrence clinical toxic parameters. general, overexpression/administration worsens presentation, whereas deletion/inactivation contributes amelioration symptoms. Thus, may be proposed common pathogenic factor sharing symptoms etiologies but appearing share some processes reasonably attributable neuroinflammation.
Language: Английский
Citations
55
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14499 - 14499
Published: Sept. 24, 2023
Over the past 30 years, majority of (pre)clinical efforts to find an effective therapy for Alzheimer’s disease (AD) focused on clearing β-amyloid peptide (Aβ) from brain since, according amyloid cascade hypothesis, was (and it is still considered by many) pathogenic determinant this neurodegenerative disorder. However, as reviewed in article, results numerous clinical trials that have tested anti-Aβ therapies date indicate plays a minor role pathogenesis AD. Indeed, even Aducanumab and Lecanemab, two antibodies recently approved FDA AD therapy, well Donanemab showed limited efficacy cognitive parameters phase III trials, despite their capability markedly lowering Aβ load. Furthermore, preclinical evidence demonstrates possesses several physiological functions, including memory formation, suggesting may part be due loss function peptide. Finally, generally accepted could result many molecular dysfunctions, therefore, if we keep chasing only Aβ, means cannot see forest trees.
Language: Английский
Citations
36
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(36), P. 8605 - 8621
Published: Jan. 1, 2023
Alzheimer's disease (AD) is a neurodegenerative that causes memory and cognitive dysfunction reduces person's decision-making reasoning functions. AD the leading cause of dementia in elderly. Patients with have increased expression pro-inflammatory cytokines nervous system, sustained inflammatory response impairs neuronal function. Meanwhile, long-term use anti-inflammatory drugs can reduce incidence to some extent. This confirms anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are emerging nanomaterial promising physicochemical properties, antioxidant. AuNPs neuroinflammation by inducing macrophage polarization toward M2 phenotype, reducing cytokine expression, blocking leukocyte adhesion, decreasing oxidative stress. Therefore, gradually attracting interest scholars used treating diseases drug delivery. Herein, we explored role mechanism The topic worth exploring future, not only help solve global public health problem but also provide reference other neuroinflammatory diseases.
Language: Английский
Citations
27
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11955 - 11955
Published: Nov. 7, 2024
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in aging populations worldwide. Recent research has proposed a novel conceptualization of AD as "type 3 diabetes", highlighting the critical roles insulin resistance impaired glucose metabolism pathogenesis disease. This article examines implications this association, exploring potential new avenues for treatment preventive strategies AD. Key evidence linking to emphasizes metabolic processes contribute neurodegeneration, including inflammation, oxidative stress, alterations signaling pathways. By framing within context, we can enhance our understanding its etiology, which turn may influence early diagnosis, plans, measures. Understanding manifestation opens up possibility employing therapeutic incorporate lifestyle modifications use antidiabetic medications mitigate cognitive decline. integrated approach improve patient outcomes deepen comprehension intricate relationship between neurodegenerative diseases disorders.
Language: Английский
Citations
13
Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 148 - 148
Published: Jan. 12, 2024
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced therapeutic interventions. This detailed review explores the critical roles of astrocytes, key cellular constituents central nervous system (CNS), in both pathophysiology and possible rehabilitation TBI. Following injury, astrocytes exhibit reactive transformations, differentiating into pro-inflammatory (A1) neuroprotective (A2) phenotypes. paper elucidates interactions with neurons, their role neuroinflammation, potential for exploitation. Emphasized strategies encompass utilization endocannabinoid calcium signaling pathways, hormone-based treatments like 17β-estradiol, biological therapies employing anti-HBGB1 monoclonal antibodies, gene therapy targeting Connexin 43, innovative technique astrocyte transplantation as means to repair damaged neural tissues.
Language: Английский
Citations
10
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Background Alzheimer's disease (AD), the leading cause of dementia, is characterized by cognitive decline and accumulation amyloid-β (Aβ). It affects millions, with numbers expected to double 2050. SMOC2, implicated in inflammation fibrosis, may play a role AD pathogenesis, particularly microglial cell function, offering potential therapeutic target. Objective (AD) leads neurodegeneration, affecting cognition, language, personality, underscoring urgency for effective treatments. Our study investigates secreted modular calcium-binding protein 2 (SMOC2) cells its impact on pathology. Methods We introduced SMOC2 overexpression interference vectors into treated Aβ. Activity phagocytosis were assessed using CCK8 flow cytometry. mRNA levels quantified qPCR, TGF-β1, p-NF-κB/NF-κB analyzed western blot. Aβ content was determined ELISA, immunofluorescence detected TNF-α, IL-1β, CD163, CD206. Results treatment inhibited activity phagocytosis, but disruption enhanced these functions (p < 0.05). increased expression levels, while reduced them 0.001). also decreased CD206, p-NF-κB/NF-κB, IL-1β Conclusions plays crucial activity, polarization, potentially through TGF-β1/NF-κB pathway, insights pathogenesis.
Language: Английский
Citations
1
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 29, 2024
The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation following ischemic stroke, phenotypic distribution of these cells can change with the progression stroke. Peroxiredoxin (PRDX) 6 phospholipase A2 (iPLA2) activity is involved generation reactive oxygen species(ROS), ROS driving activation astrocytes; however, its exact function remains unexplored. MJ33, PRDX6
Language: Английский
Citations
7
RSC Chemical Biology, Journal Year: 2022, Volume and Issue: 4(2), P. 121 - 131
Published: Nov. 22, 2022
This review describes the effects of metal ions on aggregation and toxicity profiles Aβ.
Language: Английский
Citations
24
Cells, Journal Year: 2023, Volume and Issue: 12(18), P. 2318 - 2318
Published: Sept. 20, 2023
Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher overlapping numerous cross-talk mechanisms neurodegeneration. Numerous interrelated pathways lead progression We present evidence from past pieces literature for most usual global convergent hallmarks ageing, oxidative stress, excitotoxicity-induced calcium butterfly effect, defective proteostasis including chaperones, autophagy, mitophagy, proteosome networks, neuroinflammation. Herein, we applied holistic approach identify represent shared mechanism across NDDs. Further, believe that this could be helpful in identifying key modulators NDDs, with particular focus on AD, PD, ALS. Moreover, these concepts development diagnosis novel strategies diverse
Language: Английский
Citations
16
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: April 9, 2024
Cerebrovascular diseases and their sequalae, such as ischemic stroke, chronic cerebral hypoperfusion, vascular dementia are significant contributors to adult disability cognitive impairment in the modern world. Astrocytes an integral part of neurovascular unit CNS play a pivotal role homeostasis, including ionic p H balance, neurotransmission, blood flow, metabolism. respond insults, inflammation, through unique molecular, morphological, functional changes, collectively known reactive astrogliosis. The function astrocytes has been subject debate. Initially, were thought primarily supportive maintaining structure nervous system. However, recent studies suggest that may have both beneficial detrimental effects. For example, can cause oligodendrocyte death demyelination. In this review, we will summarize (1) roles ion transporter cascade astrogliosis, (2) related dementias, (3) potential therapeutic approaches for dementing disorders targeting astrocytes. Understanding relationship between cascade, cerebrovascular reveal mechanisms targets development therapies brain associated with
Language: Английский
Citations
5