Adaptation to intermittent hypoxia protects the brain in post-traumatic stress disorder DOI Open Access
Е. Б. Манухина, В. Э. Цейликман,

Olga B. Tseilikman

и другие.

Nauchno-prakticheskii zhurnal «Patogenez», Год журнала: 2023, Номер 21(4), С. 4 - 12

Опубликована: Дек. 26, 2023

Посттравматическое стрессовое расстройство (ПТСР) развивается при тяжёлом стрессе, обычно вызванном угрожающими жизни или травмирующими ситуациями. ПТСР часто провоцирует развитие серьёзных как психических, так и соматических заболеваний. Несмотря на то, что 50-60% людей хотя бы раз в пережили травмирующие события, у большинства из них не благодаря активности эндогенных протекторных систем. Они включают себя системы антиоксидантов, белков теплового шока, простагландинов, оксида азота другие. Наиболее известным хорошо изученным способом повышения систем является адаптация к периодической нормо- гипобарической гипоксии (АГ). В обзоре представлены данные о способности АГ ограничивать повреждающие эффекты центральной нервной системе висцеральных органах обсуждаются возможные механизмы этой защиты. Post-traumatic stress disorder (PTSD) develops after severe generally induced by life-threatening or traumatizing situations. PTSD frequently provokes serious psychic and smatic diseases. Although of people have been exposed to traumatic events at least once during their lifetime most them do not develop due the activity endogenous defense systems. These systems include antioxidants, prostaglandins, nitric oxide, heat shock proteins others. The known studied method for enhancing is adaptation intermittent normo- hypobaric hypoxia (AH). This review focuses on ability AH restrict detrimental effects central nervous system visceral organs addresses possible mechanisms protection.

Язык: Русский

Blockade of A2AR improved brain perfusion and cognitive function in a mouse model of Alzheimer’s disease DOI
Mariana Sayuri Berto Udo, Julia Zaccarelli‐Magalhães, Garrett A. Clemons

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

0
Unveiling the Link: Exploring Mitochondrial Dysfunction as a Probable Mechanism of Hepatic Damage in Post-Traumatic Stress Syndrome DOI Open Access
М. V. Kondashevskaya, Л.М. Михалева,

Kseniya A. Artem’yeva

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 13012 - 13012

Опубликована: Авг. 21, 2023

PTSD is associated with disturbed hepatic morphology and metabolism. Neuronal mitochondrial dysfunction considered a subcellular determinant of PTSD, but link between damage in has not been demonstrated. Thus, the effects experimental on livers high anxiety (HA) low (LA) rats were compared, determinants underlying difference their investigated. Rats exposed to predator stress for 10 days. Then, 14 days post-stress, evaluated an elevated plus maze assigned HA LA groups according index. Experimental caused dystrophic changes hepatocytes hepatocellular evident by increased plasma ALT AST activities. Mitochondrial was as predominance small-size mitochondria rats, which positively correlated index, activities transaminases, lipids, negatively glycogen. In contrast, had medium-sized mitochondria. we show links dysfunction, damage, heightened rats. These results will provide foundation future research role pathogenesis.

Язык: Английский

Процитировано

9
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence DOI Open Access
В. Э. Цейликман,

Olga B. Tseilikman,

Oleg N. Yegorov

и другие.

Nutrients, Год журнала: 2024, Номер 16(17), С. 2856 - 2856

Опубликована: Авг. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Язык: Английский

Процитировано

3
Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation DOI Open Access
В. Э. Цейликман,

Vladislav A. Shatilov,

Maxim S. Zhukov

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14343 - 14343

Опубликована: Сен. 20, 2023

Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue treatment. Recent research has identified protective effects resveratrol in PTSD. Here, we tested behavioral and neurobiological combining cheese consumption with supplements an experimental model. Using elevated plus maze test, observed that intake resulted shift from anxiety-like behavior depressive behavior, evident increased freezing acts. However, no significant changes anxiety index value were observed. Interestingly, supplementation only led elimination half rats. We further segregated rats into two groups based on behavior: Freezing+ Freezing0 phenotypes. Resveratrol ameliorated abnormalities Monoamine Oxidize -A Brain-Derived Neurotrophic Factor gene expression hippocampus, but Moreover, negative correlation was found between number acts levels Oxidize-A mRNAs hippocampus. The study results show promise Further is warranted better understand underlying mechanisms optimize potential benefits

Язык: Английский

Процитировано

4
A diabetes-like biochemical and behavioural phenotype of Drosophila induced by predator stress DOI Creative Commons
Tatjana Krama,

Diana Bahhir,

Liina Ots

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(2002)

Опубликована: Июль 5, 2023

Predation can have both lethal and non-lethal effects on prey. The of predation instil changes in prey life history, behaviour, morphology physiology, causing adaptive evolution. chronic stress caused by sustained is comparable to conditions humans. Conditions like anxiety, depression, post-traumatic syndrome also been implicated the development metabolic disorders such as obesity diabetes. In this study, we found that predator induced during larval fruit flies Drosophila melanogaster impairs carbohydrate metabolism systemic inhibition Akt protein kinase, which a central regulator glucose uptake. However, grown with predators survived better under direct spider adult phase. Administration metformin 5-hydroxytryptophan (5-HTP), precursor neurotransmitter serotonin, reversed these effects. Our results demonstrate link between impairment, suggesting diabetes-like biochemical phenotype may be terms survival reproductive success. We provide novel animal model explore mechanisms responsible for onset disorders, are highly prevalent human populations.

Язык: Английский

Процитировано

1
Adaptation to intermittent hypoxia protects the brain in post-traumatic stress disorder DOI Open Access
Е. Б. Манухина, В. Э. Цейликман,

Olga B. Tseilikman

и другие.

Nauchno-prakticheskii zhurnal «Patogenez», Год журнала: 2023, Номер 21(4), С. 4 - 12

Опубликована: Дек. 26, 2023

Посттравматическое стрессовое расстройство (ПТСР) развивается при тяжёлом стрессе, обычно вызванном угрожающими жизни или травмирующими ситуациями. ПТСР часто провоцирует развитие серьёзных как психических, так и соматических заболеваний. Несмотря на то, что 50-60% людей хотя бы раз в пережили травмирующие события, у большинства из них не благодаря активности эндогенных протекторных систем. Они включают себя системы антиоксидантов, белков теплового шока, простагландинов, оксида азота другие. Наиболее известным хорошо изученным способом повышения систем является адаптация к периодической нормо- гипобарической гипоксии (АГ). В обзоре представлены данные о способности АГ ограничивать повреждающие эффекты центральной нервной системе висцеральных органах обсуждаются возможные механизмы этой защиты. Post-traumatic stress disorder (PTSD) develops after severe generally induced by life-threatening or traumatizing situations. PTSD frequently provokes serious psychic and smatic diseases. Although of people have been exposed to traumatic events at least once during their lifetime most them do not develop due the activity endogenous defense systems. These systems include antioxidants, prostaglandins, nitric oxide, heat shock proteins others. The known studied method for enhancing is adaptation intermittent normo- hypobaric hypoxia (AH). This review focuses on ability AH restrict detrimental effects central nervous system visceral organs addresses possible mechanisms protection.

Язык: Русский

Процитировано

0