Cytotherapy, Год журнала: 2023, Номер 25(11), С. 1176 - 1185
Опубликована: Июль 29, 2023
Язык: Английский
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Фев. 5, 2025
Traumatic brain injury (TBI) is a complex condition involving mechanisms that lead to dysfunction and nerve damage, resulting in significant morbidity mortality globally. Affecting ~50 million people annually, TBI's impact includes high death rate, exceeding of heart disease cancer. Complications arising from TBI encompass concussion, cerebral hemorrhage, tumors, encephalitis, delayed apoptosis, necrosis. Current treatment methods, such as pharmacotherapy with dihydropyridines, high-pressure oxygen therapy, behavioral non-invasive stimulation, have shown limited efficacy. A comprehensive understanding vascular components essential for developing new treatments improve blood vessel-related damage. Recently, mesenchymal stem cells (MSCs) promising results repairing mitigating Studies indicate MSCs can promote neurogenesis angiogenesis through various mechanisms, including releasing bioactive molecules extracellular vesicles (EVs), which help reduce neuroinflammation. In research, the distinctive characteristics positioned them highly desirable cell sources. Extensive investigations been conducted on regulatory properties their manipulation, tagging, transportation techniques brain-related applications. This review explores progress prospects MSC therapy TBI, focusing action, therapeutic benefits, challenges potential limitations using treating neurological disorders.
Язык: Английский
Процитировано
1
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 11, 2025
This study aims to assess the effectiveness and safety of mesenchymal stem cell (MSC) transplantation in treatment autoimmune rheumatic immune diseases through randomized controlled trials (RCTs). Two researchers conducted a comprehensive search Chinese English databases from their inception until Dec. 2023. The literature screening data extraction were then performed. Statistical analysis was carried out using RevMan 5.4 software. A total 42 relevant RCTs, involving 2,183 participants, ultimately included this study. These RCTs encompassed four types bone diseases, namely rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthritis, systemic sclerosis arthritis, lupus erythematosus (SLE), inflammatory bowel disease, multiple sclerosis, primary Sjögren's syndrome (PSS). systematic review indicates that MSC may improve RA, PSS. meta-analysis reveals significantly improved symptoms patients with OA [VAS (visual analogue scale): marrow: SMD = − 0.95, 95% CI 1.55 0.36, P 0.002; umbilical cord: 1.25, 2.04 0.46, adipose tissue: -1.26, -1.99 0.52, 0.0009)], SLE [Systemic disease activity index (SLEDAI): 2.32, 3.59 1.06, 0.0003], [clinical efficacy: RR 2.02, 1.53 2.67, < 0.00001]. However, not (Ssc). Importantly, did increase incidence adverse events (OA: 1.23, 0.93 1.65, 0.15; SLE: 0.83, 0.28 2.51, 0.76; Inflammatory disease: 0.99, 0.81 1.22, 0.96; Multiple sclerosis: 1.12, 1.53, 0.50), supporting its profile across studies. findings suggest holds promise for several while highlighting areas where further research is warranted. have potential treat diseases. Moreover. appears be relatively safe could considered as viable alternative option
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Май 10, 2023
Hepatectomy is an effective surgical method for the treatment of liver diseases, but intraoperative bleeding and postoperative function recovery are still key issues. This study aims to develop a composite hydrogel dressing with excellent hemostatic properties, biocompatibility, ability promote cell regeneration. The modified gelatin matrix (GelMA, 10%) was mixed equal volumes sodium alginate-dopamine (Alg-DA) at concentrations 0.5%, 1%, 2%. Then cross-linking agent (0.1%) added prepare different hydrogels under UV light, named GelMA/Alg-DA-0.5, GelMA/Alg-DA-1 GelMA/Alg-DA-2, respectively. All prepared has porous structure porosity greater than 65%, could be stabilized in gel state after being cross-linked by ultraviolet light. Physicochemical characterization showed that elastic modulus, water absorption, adhesion, compressibility were improved increasing Alg-DA content. Furthermore, exhibits vitro degradability, good function. Among all tested groups, group performed best. To further enhance its application potential field regeneration, adipose-derived mesenchymal stem exosomes (AD-MSC-Exo) loaded into hydrogel. Under same conditions, GelMA/Alg-DA-1/Exo promoted proliferation migration more effectively without extracellular vesicles. In conclusion, AD-MSC-Exo great wound hemostasis
Язык: Английский
Процитировано
14
Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11
Опубликована: Апрель 16, 2024
Craniofacial reconstruction faces many challenges, including high complexity, strong specificity, severe injury, irregular and complex wounds, risk of bleeding. Traditionally, the “gold standard” for treating craniofacial bone defects has been tissue transplantation, which involves transplantation bone, cartilage, skin, other tissues from parts body. However, shape cartilage structures varies greatly is distinctly different ordinary long bones. bones originate neural crest, while mesoderm. These factors contribute to poor effectiveness in repairing defects. Autologous mesenchymal stem cell exhibits excellent pluripotency, low immunogenicity, minimally invasive properties, considered a potential alternative Researchers have found that both craniofacial-specific cells body significant effects on restoration bones, adipose tissue. In addition, continuous development application engineering technology provide new ideas repair. With exploration by researchers technology, use autologous gradually accepted promoted. This article will review applications various types related repair reconstruction.
Язык: Английский
Процитировано
4
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 319 - 330
Опубликована: Янв. 1, 2025
Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging. This study was developed to explore effects combination laser BMSC injection on photoaging underlying molecular mechanisms. In total, 24 mice with experimentally photoaged were separated into control, fractional treatment, therapy, groups. Samples dorsal from these animals subjected hematoxylin eosin staining or Masson's trichrome staining. addition, immunohistochemical analyses real-time polymerase chain reaction conducted detect MMP-3 MMP-9 expression. After 1 week, both dermal thickness collagen fiber density significantly increased groups as compared control group (P<0.05), while parameters all after 4 weeks relative most pronounced effect therapy (P<0.05). mRNA protein levels decreased weeks. Combination more effective than either therapeutic approaches isolation a for skin. The improvement may be due decrease expression therapy.
Язык: Английский
Процитировано
0
Communications Biology, Год журнала: 2025, Номер 8(1)
Опубликована: Март 19, 2025
Obesity arises from an imbalance between adipogenesis and adipocyte thermogenesis. Interleukin-27 (IL-27), a heterodimer cytokine, is known to promote thermogenesis in brown adipose tissue. However, its role remains unclear. This study aims investigate the effects of IL-27 on both vitro vivo, elucidate underlying mechanisms. In vitro, adipogenic differentiation model adipose-derived mesenchymal stem cells (ADSCs) demonstrate that non-cytotoxic ADSCs inhibits differentiation. using high-fat diet (HFD)-induced obese mouse targeted tissue-specific overexpression adeno-associated viral (AAV) vector, we confirm suppresses adipogenesis, prevents weight gain, improves glucose lipid metabolic homeostasis mice. Additionally, inhibition by mediated through HDAC6 activation TGFβ/Smad3 signaling pathway. Our suggests potential therapeutic target for obesity disorders.
Язык: Английский
Процитировано
0
Опубликована: Март 29, 2025
Osteoarthritis is a degenerative disease of the cartilage that affects millions. Its pathology characterized by catabolic and anabolic factors can be modified due to age, weight genetics increase severity deterioration. Current standards care may manage symptoms, but there currently no proven treatment osteoarthritis reverse degeneration build back ECM. Due this, stem cells have been investigated as potential therapy. This because their unique abilities differentiate into many cell types even regenerate tissue. Mesenchymal targeted specifically high reproduction rate other important factors. Studies done concluded are statistically significant benefits in treating osteoarthritic joints with mesenchymal derived from adipose tissue umbilical cord well synovial. Although these recorded, it still imperative further studies conducted test longevity its possible negative side effects.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Март 8, 2023
The conventional therapeutic approaches to treat autoimmune diseases through suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory drugs, are not adequately practical. Moreover, these regimens associated with considerable complications. Designing tolerogenic strategies based on stem cells, their extracellular vesicles (EVs) seems open a promising path managing diseases’ vast burden. Mesenchymal stem/stromal cells (MSCs), dendritic regulatory T (Tregs) main cell types applied restore status; MSCs play more beneficial role due amenable properties extensive cross-talks different cells. With existing concerns about employment of new cell-free paradigms, EV-based therapies, gaining attention in this field. Additionally, EVs’ unique have made them be known smart immunomodulators considered potential substitute for therapy. This review provides an overview advantages disadvantages cell-based methods treating diseases. study also presents outlook future EVs implemented clinics patients.
Язык: Английский
Процитировано
9
Acta Pharmacologica Sinica, Год журнала: 2024, Номер 45(11), С. 2300 - 2312
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
3
Molecular Biology Reports, Год журнала: 2023, Номер 50(12), С. 10461 - 10469
Опубликована: Окт. 30, 2023
Язык: Английский
Процитировано
6