Effect of First Long Term Training on Platelet Function in Thoroughbreds DOI Open Access
Arianna Miglio, Emanuela Falcinelli, Katia Cappelli

и другие.

Опубликована: Дек. 11, 2023

Training has a significative effect on physiology of blood coagulation both in humans and horses. Several hemostatic changes have been reported after exercise the horse but data available are inconclusive. The aim this study was to investigate platelet activation primary platelet-related hemostasis modifications young untrained Thoroughbred racehorses first 4-month timeframe incremental training period order improve knowledge topic. Twenty-nine clinically healthy, untrained, 2-year-old racehorses. Never trained Thoroughbreds were followed during their sprint schedule. Blood collection performed once month (T-30, T0, T30, T60, T90). Platelet aggregation measured by light transmission aggregometer response various agonists: adenosine diphosphate (ADP), collagen calcium ionophore A23187. function evaluated using Function Analyzer (PFA-100®) collagen/ADP collagen/adrenaline cartridges. Nitrite-nitrate (NOx) plasma concentrations colorimetric assay assess vivo nitric oxide bioavailability. investigated also through gene expression analyses (selectin P-SELP, ectonucleotidase CD39-ENTPD1, prostaglandin I2 synthase-PTGIS, endothelial synthase 3-NOS3). Differences among time points analyzed mean±SEM calculated. Significant identified compared with T-30 increase (collagen:32.6±4.8 vs 21.6±4.9%; ADP: 35.5±2.0 24.5±3.1%; A23187: 30±4.7 23.8±4%) shorter closure C-ADP cartridges (75.6±4.4 87.7±3.4 sec) that tended return baseline value at T90. NOx significantly increased 30 days program baseline. long-term induce hyperactivity already Thoroughbreds. Regular physical blunts negative effects acute efforts platelets activation.

Язык: Английский

High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity DOI

Uswatun Hasanah,

Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu

и другие.

Journal of Basic and Clinical Physiology and Pharmacology, Год журнала: 2024, Номер 35(1-2), С. 71 - 78

Опубликована: Янв. 1, 2024

Abstract Objectives Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming However, appropriate effective intensity for obese subjects still debated. Therefore, this study aims to prove effect of differences aerobic-resistance combination increasing irisin IL-6 levels women. Methods A total 32 women were selected as administered interventions low-intensity (Q 2 ), moderate-intensity 3 high-intensity 4 ). ELISA was used measure all samples. Statistical analysis one-way ANOVA Turkey’s-Honest Significant Difference (HSD) post hoc test. Results The mean Δ control groups 1 Q , 0.27 ± 2.54, 2.07 2.55, 5.99 6.25, 7.98 2.82 pg/mL (p=0.015). 0.06 0.81 ng/mL 0.59 0.67 1.99 1.65 4.63 3.57 (p=0.001). Conclusions This proved three types combined increased myokine levels, such IL-6. provided most optimal improvement Future studies needed design long-term programs specifically adolescent using findings from study.

Язык: Английский

Процитировано

2
Exposure of cumulative atherogenic index of plasma and the development of prediabetes in middle-aged and elderly individuals: evidence from the CHARLS cohort study DOI Creative Commons
Yang Zou, Song Lu, Dongdong Li

и другие.

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

2
Association of aerobic exercise habits with higher albumin-globulin ratio and lower cellular immune-inflammatory markers: implication of the preventive effect of aerobic exercise on atherosclerotic cardiovascular disease DOI
Shigemasa Tani,

Kazuhiro Imatake,

Yasuyuki Suzuki

и другие.

Heart and Vessels, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

2
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS DOI Creative Commons
Djamel Nehar-Belaid, Mark Sokolowski,

Sathyabaarathi Ravichandran

и другие.

Seminars in Immunology, Год журнала: 2023, Номер 70, С. 101842 - 101842

Опубликована: Сен. 15, 2023

Vaccines are among the greatest inventions in medicine, leading to elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, effectiveness vaccines varies individuals. In fact, while some recipients mount a robust response vaccination that protects them from disease, others fail respond. Multiple clinical and epidemiological factors contribute this heterogeneity responsiveness. Systems immunology studies fueled by advances single-cell biology have been instrumental uncovering pre-vaccination immune cell types genomic features (i.e., baseline state, BIS) associated with vaccine Here, we review shape BIS, characteristics BIS responsiveness frequently studied influenza, COVID-19, bacterial pneumonia, malaria). Finally, discuss potential strategies enhance high-risk groups, focusing specifically on older adults.

Язык: Английский

Процитировано

5
No causal association between the volume of strenuous exercise and coronary atherosclerosis: a two-sample Mendelian randomization study DOI Creative Commons
Zijie Xiao,

Guolin Huang,

Guanhong Li

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Апрель 25, 2024

Objective Several observational studies have shown that high-volume and high-intensity exercise training increases the prevalence severity of coronary atherosclerosis, but causal effect still remains uncertain. This study aims to explore relationship between volume strenuous (SE) atherosclerosis (CA) using Mendelian randomization (MR) method. Method The exposure factors were two basic parameters (duration frequency exercise), outcome factor was relevant genetic loci extracted from summary data genome-wide association (GWAS) as instrumental variables, MR analyses performed inverse variance weighting (IVW) method, weighted median MR-egger Sensitivity heterogeneity analysis, pleiotropy “leave-one-out” original results tested other sets. Result IVW showed no duration (DOSE) [OR = 0.9937, 95% CI (0.9847, 1.0028), P 0.1757] (FOSE) in last 4 weeks 0.9930, (0.9808, 1.0054), 0.2660] atherosclerosis. All above validated with Conclusion present supports SE CA not found, provides valuable insights into choice scientific correct cardiac rehabilitation (CR).

Язык: Английский

Процитировано

1
Exercise as an anti-inflammatory Therapy in Axial Spondyloarthritis Therapeutic Intervention (EXTASI) study: a randomized controlled trial DOI Creative Commons
Matthew J. Roberts, Malik Hamrouni, Victoria Linsley

и другие.

Rheumatology Advances in Practice, Год журнала: 2024, Номер 8(2)

Опубликована: Янв. 1, 2024

Abstract Objectives Axial SpA (axSpA) is a chronic inflammatory disease, yet despite known anti-inflammatory effects of exercise, the effect exercise on immune cell populations and associated profiles in axSpA unknown. This randomized controlled trial investigated 12 weeks walking symptom severity, cardiometabolic health, biomarkers populations. Methods Twenty people (60% male) living with who were stable dose NSAIDs participated. Participants randomly assigned to control or (30 min five times per week). invited back every 4 for assessment. Results There was 0% dropout rate no adverse events group, showing well tolerated. Home-based lowered proportion pro-inflammatory monocytes, whereas they increased group. Changes lower IL-6 CRP concentrations, spinal pain systolic blood pressure these markers Reductions monocytes independent body fat percentage. Conclusions Supplementing NSAID therapy can improve axSpA, coinciding reductions pain. Importantly, tolerated, suggesting be used as an adjuvant treatments. should now explored have had high enough disease activity necessitate prescription biologic synthetic DMARD Trial registration ClinicalTrials.gov (http://clinicaltrials.gov), NCT04368494.

Язык: Английский

Процитировано

1
Physical Activity Volume, Intensity, and Mortality: Harmonized Meta-Analysis of Prospective Cohort Studies DOI Creative Commons
Jakob Tarp, Knut Eirik Dalene, Morten Wang Fagerland

и другие.

American Journal of Preventive Medicine, Год журнала: 2024, Номер 67(6), С. 887 - 896

Опубликована: Июль 31, 2024

IntroductionIt is unclear whether moderate-to-vigorous physical activity (MVPA) associated with a lower mortality risk, over and above its contribution to total volume.MethodsA of 46,682 adults (mean age: 64 years) were included in meta-analysis nine prospective cohort studies. Each generated tertiles accelerometry-measured volume volume-adjusted MVPA. Hazard ratios (HR, 95% confidence intervals [CI]) for estimated separately joint models combining Data was collected between 2001-2019 analyzed 2023.ResultsDuring mean follow-up years, 4,666 deaths recorded. Higher volume, greater from MVPA, each hazard multivariable-adjusted models. Compared the least active tertile, higher (HRs: 0.62; 95%CI, 0.58, 0.67 0.50; 0.42, 0.60 ascending tertiles). Similarly, MVPA 0.94; 0.85, 1.04 0.88; 0.79, 0.98). In analysis, only observed middle tertile volume.ConclusionsThe risk extent than volume. Integrating any intensity into daily life may aged older adults, small added benefit if same amount performed intensity.

Язык: Английский

Процитировано

1
Atherosclerosis: Progression, risk factors, diagnosis, treatment, probiotics and synbiotics as a new prophylactic hope DOI Creative Commons

Siloni Patial,

Akshita Sharma, Khem Raj

и другие.

The Microbe, Год журнала: 2024, Номер 5, С. 100212 - 100212

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

1
Prevalence and Influencing Risk Factors of Dyslipidemia DOI

·木塔力甫 木尼热

Advances in Clinical Medicine, Год журнала: 2023, Номер 13(11), С. 17090 - 17096

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

2
Estimation of Machine Learning-Based Models to Predict 5-Year or 10-Year Risk of Dementia in Patients with Atherosclerotic Cardiovascular Diseases: A UK Biobank Study DOI
Zhengsheng Gu, Shuang Liu, Huijuan Ma

и другие.

Опубликована: Янв. 1, 2024

Background: The Atherosclerotic Cardiovascular Disease (ASCVD) is associated with dementia. However, the risk factors of dementia in ASCVD patients remain unclear.Methods: After excluding baseline and follow-up losses, 29,630 were included from UK biobank. We implemented a data-driven strategy, identifying predictors 316 variables developing ML model to predict incident dementia, Alzheimer's (AD), Vascular Dementia (VD) within five, ten, longer-term follow-up.Findings: During mean 10·3 years, 1336, 425 538 developed AD VD, respectively. model, incorporating 10 predictors, demonstrated high accuracy all (AUC 0·861±0·016), 0·820±0·022), VD 0·853±0·061).Interpretation: Our utilizing accessible reliably identified individuals at patients.Funding: This study was funded by grants Natural Science Foundation Shanghai (23JS1400500), ShenKang Hospital Development Center (SHDC2020CR1038B) 234 discipline peak climbing program Changhai hospital (2019YXK013).Declaration Interest: authors declare no conflict interest related this work.Ethical Approval: All participants electronically consented utilization their data for health-related research. Biobank obtained ethical clearance NHS North West Centre Research Ethics Committee (Ref: 11/NW/0382).

Язык: Английский

Процитировано

0