Aloe vera―An Extensive Review Focused on Recent Studies

Foods, Год журнала: 2024, Номер 13(13), С. 2155 - 2155

Опубликована: Июль 8, 2024

Since ancient times,

Язык: Английский

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Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs

Applied Sciences, Год журнала: 2023, Номер 13(10), С. 6045 - 6045

Опубликована: Май 15, 2023

The cytochrome P450 (CYP) enzyme family is the major system catalyzing phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in environment. A part CYP-dependent xenobiotic due to polymorphic inducible enzymes, which may, quantitatively or qualitatively, alter enhance drug toxicity. Drug–drug interactions are mechanisms caused by inhibition and/or induction CYP enzymes. Particularly, monooxygenases catalyze hydroxylation reactions form hydroxylated metabolites. secondary metabolites sometimes as active parent compound, even more active. aim this review summarize some significative examples common drugs used for treatment diverse diseases underline activity toxicity their

Язык: Английский

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The Ongoing Impact of COVID-19 on Pediatric Obesity

Pediatric Reports, Год журнала: 2024, Номер 16(1), С. 135 - 150

Опубликована: Фев. 2, 2024

In the developed world, pediatric obesity (PO) has been a major health concern since last century, and this condition may lead to detrimental life-long physical mental comorbidities. Currently, its prevalence increased in low- middle-income countries many high-income countries. Thus, provision of effective tailored care for children their families become vital. The social consequences COVID-19 pandemic are known everywhere, among these, it argued that had impact on PO. Overall, growth PO over decade enhanced by pandemic. During pandemic, children, adolescents young adults gained weight as population dealt with sedentary lifestyles changes food habits. review, we want highlight

Язык: Английский

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BRCA1/2 Mutations and Breast/Ovarian Cancer Risk: A New Insights Review

Reproductive Sciences, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Язык: Английский

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Natural Products for the Prevention, Treatment and Progression of Breast Cancer

Cancers, Год журнала: 2023, Номер 15(11), С. 2981 - 2981

Опубликована: Май 30, 2023

In this review, we summarize the most used natural products as useful adjuvants in BC by clarifying how these may play a critical role prevention, treatment and progression of disease. is leading cancer, terms incidence, that affects women. The epidemiology pathophysiology were widely reported. Inflammation cancer are known to influence each other several tumors. case BC, inflammatory component precedes development neoplasm through slowly increasing prolonged inflammation also favors its growth. therapy involves multidisciplinary approach comprising surgery, radiotherapy chemotherapy. There numerous observations showed effects some substances, which, integration with classic protocols, can be not only for prevention or order prevent recurrences induce state chemoquiescence but chemo- radiosensitizers during therapy.

Язык: Английский

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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Nutrients, Год журнала: 2024, Номер 16(16), С. 2644 - 2644

Опубликована: Авг. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Язык: Английский

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Aldehydes: What We Should Know About Them

Organics, Год журнала: 2024, Номер 5(4), С. 395 - 428

Опубликована: Окт. 21, 2024

From Egyptian mummies to the Chanel N° 5 perfume, aldehydes have been used for a long time and continue impact our senses in wide range of perfumes, foods, beverages. Aldehydes represent one categories volatile organic compounds (VOCs), which are categorized as chemicals with boiling points up 260 °C can be found indoor environments gaseous phase. Because their potential or known hazardous properties humans, World Health Organization (WHO)-Europe provided some guidelines that may prevent several health risks. Indeed, aldehydes, reported risky retired from market, such butylphenyl methylpropional (BMHCA). The purpose this review is summarize most important indoors outdoors analyse depth toxicological aspects these compounds, whose presence perfumes often underestimated. In addition, ingredients’ synonyms literature same compound were unified order simplify identification.

Язык: Английский

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Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 13, 2025

Язык: Английский

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(E)-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1H-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Antimitotic Agents Targeting Breast Cancer

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 118 - 118

Опубликована: Янв. 17, 2025

Background/Objectives: The synthesis of (E)-1-(1,3-diphenylallyl)-1H-1,2,4-triazoles and related compounds as anti-mitotic agents with activity in breast cancer was investigated. These were designed hybrids the microtubule-targeting chalcones, indanones, aromatase inhibitor letrozole. Methods: A panel 29 synthesized examined by a preliminary screening estrogen receptor (ER) progesterone (PR)-positive MCF-7 cells together cell cycle analysis tubulin polymerization inhibition. Results: (E)-5-(3-(1H-1,2,4-triazol-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)-2-methoxyphenol 22b identified potent antiproliferative compound an IC50 value 0.39 mM cells, 0.77 triple-negative MDA-MB-231 0.37 leukemia HL-60 cells. In addition, demonstrated sub-micromolar range against NCI 60 line including prostate, melanoma, colon, leukemia, non-small lung cancers. G2/M phase arrest induction apoptosis inhibition demonstrated. Immunofluorescence studies confirmed that targeted while computational docking predicted binding conformations for colchicine site tubulin. Compound also selectively inhibited aromatase. Conclusions: Based on results obtained, these novel are suitable candidates further investigation cancer.

Язык: Английский

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Computational Exploration of Multitarget Effects of Curcumin in Breast Cancer Treatment

Pharmaceutical Fronts, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Curcumin, a bioactive compound derived from Curcuma longa, has shown promising potential in breast cancer therapy due to its multitarget pharmacological effects. This study aimed explore the molecular mechanisms underlying curcumin's anticancer activity using an integrative computational approach, including predictive modeling, docking, and pathway enrichment analysis. Curcumin demonstrated strong binding affinities critical targets such as matrix metalloproteinase-9 (MMP9), protein kinase B (AKT1), epidermal growth factor receptor (EGFR), signal transducer activator of transcription 3 (STAT3), which are implicated pathways regulating cell survival, proliferation, invasion, metastasis. Gene Ontology Kyoto Encyclopedia Genes Genomes analyses revealed ability modulate processes like apoptosis, inflammation, signaling, emphasizing therapeutic versatility. Molecular docking dynamics simulations further validated stable interactions with key targets. Complementing findings, vitro studies MCF-7 cells confirmed dose-dependent cytotoxic These results highlight complementary agent management, vivo needed substantiate clinical utility studies.

Язык: Английский

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