Bioorganic Chemistry, Год журнала: 2024, Номер 147, С. 107370 - 107370
Опубликована: Апрель 14, 2024
Язык: Английский
Expert Review of Anticancer Therapy, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (mBC) remains a prevalent and challenging disease. Endocrine therapy (ET) combined with CDK4/6 inhibitors is the first-line standard of care, yet resistance mechanisms, including ESR1 mutations, drive disease progression. Novel oral selective estrogen receptor degraders (SERDs) have emerged as promising therapeutic agents after progression secondary to mutations. However, available studies on SERDs differ in design, study population, outcomes, necessitating critical review data. This explores clinical efficacy, safety profiles HR-positive, mBC, particularly following inhibitors. Recent key trials, EMERALD, SERENA-2, EMBER-3 AMEERA-3, are analyzed, highlighting their efficacy overcoming resistance, especially ESR1-mutant populations. Oral offer enhanced bioavailability convenience compared fulvestrant, representing advancement endocrine therapy. Their integration into treatment strategies, combination regimens ctDNA-driven approaches, may improve patient outcomes address mechanisms. other than refinement for selection limited. Further trials needed optimize SERD use define most effective strategies SERDs.
Язык: Английский
Процитировано
0
Green Chemistry Letters and Reviews, Год журнала: 2025, Номер 18(1)
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Апрель 1, 2025
Breast cancer is a significant healthcare challenge, and despite advancements in treatment, the risk of recurrence remains critical concern, particularly for postmenopausal women. Understanding factors that contribute to this essential improving monitoring prevention strategies, ultimately enhancing long-term care disease management patient population. The study analyzes scholarly literature on patterns Caucasian women with prior breast cancer, highlighting potential innovative insights reduce mortality improve survival. We used R software "R-Bibliometrix" package analyze recurrence. Data was collected from Web Science Core Collection database identify relevant documents highlight collaborative efforts commonly terminology. extensive analysis included 500 articles authored by 3,204 individuals 195 distinct sources, all published between 2010 2024. It specifically focused assessing results underscored several influencing recurrence, encompassing hormonal factors, lifestyle influences, effectiveness various types adjuvant therapy, role genetic factors. In conclusion, research highlights multifaceted nature contributing believe not only enhances current understanding but also provides clear directions future improvements clinical practice health policy.
Язык: Английский
Процитировано
0
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 1, 2025
Cancer is a rising issue worldwide, and numerous studies have focused on understanding the underlying reasons for its occurrence finding proper ways to defeat it. By applying technological advances, researchers are continuously uncovering updating treatments in cancer therapy. Their vast functions regulation of cell growth proliferation their significant role progression diseases, including cancer. This review provides comprehensive analysis ncRNAs breast cancer, focusing long non-coding RNAs such as HOTAIR, MALAT1, NEAT1, well microRNAs miR-21, miR-221/222, miR-155. These pivotal regulating proliferation, metastasis, drug resistance, apoptosis. Additionally, we discuss experimental approaches that useful studying them highlight advantages challenges each method. We then explain results these clinical trials offer insights future by discussing major existing gaps. On basis an extensive number studies, this valuable into potential Key findings show even though undeniable there still complications associated with therapeutic use. Moreover, absence sufficient experiments regarding application mouse models, which area work on. emphasizing crucial ncRNAs, underscores need innovative further explore
Язык: Английский
Процитировано
0
Public Health, Год журнала: 2025, Номер 242, С. 340 - 351
Опубликована: Апрель 5, 2025
This study aimed to assess global, regional, and national trends in breast cancer burden attributable high body mass index (BMI) from 1990 2021 provide projections up 2036 using data the Global Burden of Disease (GBD) study. Systematic analysis GBD dataset. We extracted BMI-related dataset, covering 204 countries territories. Age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), estimated annual percentage changes (EAPCs) were calculated analyze temporal patterns regional differences. Future projected Bayesian age-period-cohort (BAPC) model. In 2021, BMI contributed 44,707 deaths 1,041,309 DALYs globally, reflecting a 138.5 % 142.7 increase, respectively, compared 1990. While global age-standardized DALY remained relatively stable, absolute significantly increased, particularly low- middle-SDI regions. High-SDI regions exhibited highest rates, but low-SDI showed fastest growth. Projections indicate that due will continue rise until 2036, driven by increasing obesity insufficient healthcare resources. High is major driver burden, showing not only high-income more prominently Effective strategies, including public health interventions targeting management, are needed control rising burden.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 7, 2025
Abstract Breast cancer is the most commonly diagnosed worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics. Sonodynamic therapy (SDT) a promising approach for tumor elimination, using sonosensitizers that preferentially accumulate tissues are activated by low-intensity ultrasound produce reactive oxygen species. However, clinical translation of SDT faces challenges, including limited efficiency resistance posed microenvironment. The emergence nanomedicine offers innovative strategies address these obstacles. This review discusses enhancing efficacy sonosensitizers, rational structural modifications, improved tumor-targeted enrichment, microenvironment remodeling, imaging-guided therapy. Additionally, SDT-based multimodal therapies, such as sono-chemotherapy, sono-immunotherapy, sono-photodynamic therapy, their potential applications breast treatment summarized. underlying mechanisms briefly outlined. Finally, this highlights current challenges prospects SDT, providing insights into future may improve outcomes cancer. Graphical abstract
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 3992 - 3992
Опубликована: Апрель 23, 2025
The metabolism of drugs and foreign substances in humans typically involves multiple enzymatic steps, particularly phase-1 biotransformation the liver, where various cytochrome P450 monooxygenases (CYPs) play crucial roles. This complexity can lead to a wide range metabolites. Understanding contributions individual CYPs their interactions within these intricate enzyme cascades be challenging. We recently developed an vitro platform employing Chinese Hamster Ovarian (CHO) cell clones. These clones express human oxidoreductase (CPR), each is defined by specific CYP expression, thus exhibiting no detectable endogenous activity (mono-CYP CHO platform). In this study, we investigated whether mono-CYP suitable tool for modeling complex drug metabolization reactions vitro. Tamoxifen (TAM) was selected as model substance due its role prodrug widely used breast cancer therapy, main active metabolite, endoxifen, arises from two-step primarily involving system. Specifically, combined CYP3A4 CYP2D6 believed essential efficient endoxifen production. However, physiological pathway TAM more interconnected, reasons TAM’s therapeutic success variability among patients are not yet fully understood. Analogous our introduced mono-CYP3A4 cells, generated line expressing CPR CYP2D6, including analysis expression activity. Comparative studies on were performed with both models individually co-culture intact cells well isolated microsomes. Supernatants analyzed HPLC calculate metabolite. All picked mono-CYP2D6 expressed similar protein amounts but showed different activities. Mono-CYP2D6 clone 18 most based microsomal assays. conversion -3A4 clones, combination both, resulted formation expected microsomes produced highest detected 4-hydroxytamoxifen along N-desmethyltamoxifen small N,N-didesmethyltamoxifen. only metabolite notable quantities mono-CYP3A4, while present trace amounts. CYP2D6/3A4 equal mixtures microsomes, all metabolites at concentrations around 50% those indicating significant synergistic effects. conclusion, confirmed synthesizing indicated that also involved producing by-metabolite differences spectra between two highlight specificity sensitivity
Язык: Английский
Процитировано
0
BMC Anesthesiology, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 24, 2025
The serratus posterior superior intercostal plane block (SPSIPB) is a newly described truncal block. This study aimed to compare the effects of SPSIPB with conventional methods on postoperative opioid consumption and pain scores within 24 h postoperatively. randomized controlled trial included 60 patients aged 18-65 years an American Society Anesthesiologists Physical Status I-III. Patients were randomly assigned either or control group. primary outcome was cumulative first Secondary outcomes resting dynamic Numerical Rating Scale (NRS) scores, Quality Recovery (QoR)-15 questionnaire intraoperative remifentanil consumption, incidence nausea vomiting. Total tramadol significantly lower in group during 12 at end 24th hour postoperatively compared (p < 0.05). NRS score 0 = 0.001), whereas no significant differences observed other time-points. QoR-15 higher Furthermore, had 0.003). Nausea vomiting more frequent Serratus reduced use, improved recovery quality after oncoplastic breast surgery. NCT06225908, registered ClinicalTrials.gov.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(12), С. 1883 - 1883
Опубликована: Июнь 14, 2024
Breast cancer is the most common tumor in women. Chemotherapy gold standard for treatment; however, severe side effects and resistance are major obstacles to chemotherapy success. Numerous dietary components phytochemicals have been found inhibit molecular signaling pathways associated with different stages of breast development. In particular, this review focused on antitumor PUFAs, enzymes, glucosinolates against cancer. The databases were consulted search vitro preclinical studies; only those solid scientific evidence reporting protective treatment included. A consistent number studies highlighted that can remarkable therapeutic as single agents or combination other anticancer agents, administered at concentrations via routes administration. These provide a natural strategy chemoprevention, reduce risk recurrence, impair cell proliferation viability, induce apoptosis. Some these bioactive compounds origin, show poor solubility low bioavailability; hence, encapsulation nanoformulations promising tools able increase clinical efficiency.
Язык: Английский
Процитировано
3
Viruses, Год журнала: 2024, Номер 16(9), С. 1484 - 1484
Опубликована: Сен. 18, 2024
More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 individuals living HIV/acquired syndrome (AIDS). Although treatments against HIV infection available, AIDS remains a serious disease. Combination antiretroviral therapy (cART), also known as highly active (HAART), consists of treatment combination several drugs that block multiple stages in replication cycle. However, increasing usage cART is inevitably associated emergence drug resistance. In addition, development persistent cellular reservoirs latent critical obstacle to viral eradication since rebound takes place once anti-retroviral (ART) interrupted. Thus, efforts being applied new generations drugs, vaccines and types cART. this review, we summarize antiviral therapies used for HIV/AIDS, both individual agents therapies, highlight role macrophages most recent clinical studies related
Язык: Английский
Процитировано
3