Heavy metals in biological samples of cancer patients: a systematic literature review

BioMetals, Год журнала: 2024, Номер 37(4), С. 803 - 817

Опубликована: Фев. 12, 2024

Abstract The majority of the so-called heavy metals are suspected to be involved in a number pathologies and play role human carcinogenesis. Some them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) nickel (Ni)) have been defined as carcinogens, increasing susceptibility tumor development progression humans. Moreover, Ni, Cr, Cd, Hg, Pb together with zinc (Zn) iron (Fe), may capable stimulating breast cancer reducing patient’s sensitivity treatment through alterations DNA methylation. In patients gastric cancers, levels various augmented hypothesized amplify expression epidermal growth factor receptor type 2 gene. Cd increase risk lung negative impact on overall survival patients. To investigate relation between biological samples risk, occurrence individuals, comprehensive review work was performed, focus breast, lung, prostate cancers. An extensive search strategy devised ensure relevant literature could identified, PECO framework being adopted facilitate this identify key terms. As evidenced review, there is substantial data support hypothesis that influence progression. Unluckily papers dealing determination directly from tissues still rather limited, so we decided expand scope also analyses carried out other samples, urine, plasma, hair, nail, etc. studies reviewed showed several limitations current knowledge gaps present require further investigation improve our comprehension different tumorigenesis. Graphical abstract

Язык: Английский

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Escape from senescence: molecular basis and therapeutic ramifications

The Journal of Pathology, Год журнала: 2023, Номер 260(5), С. 649 - 665

Опубликована: Авг. 1, 2023

Abstract Cellular senescence constitutes a stress response mechanism in reaction to plethora of stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While withdrawal has been perceived as permanent, recent evidence cancer research introduced the so‐called escape‐from‐senescence concept. In particular, under certain conditions, senescent may resume proliferation, acquiring highly aggressive features. As such, they have associated with tumour relapse, rendering less effective inhibiting progression. Thus, conventional treatments, incapable eliminating senescence, benefit if revisited include senolytic agents. To this end, it is anticipated that assessment burden everyday clinical material by pathologists will play crucial role near future, laying foundation for more personalised approaches. Here, we provide an overview investigations phenomenon, identified mechanisms, well major implications pathology therapy. © 2023 The Authors. Journal Pathology published John Wiley & Sons Ltd on behalf Pathological Society Great Britain Ireland.

Язык: Английский

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Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Biology, Год журнала: 2023, Номер 12(4), С. 558 - 558

Опубликована: Апрель 6, 2023

Background: Senescence is a cellular aging process in all multicellular organisms. It characterized by decline functions and proliferation, resulting increased damage death. These conditions play an essential role significantly contribute to the development of age-related complications. Humanin mitochondrial-derived peptide (MDP), encoded mitochondrial DNA, playing cytoprotective preserve function cell viability under stressful senescence conditions. For these reasons, humanin can be exploited strategies aiming counteract several processes involved aging, including cardiovascular disease, neurodegeneration, cancer. Relevance disease: appears decay organ tissue function, it has also been related diseases, such as conditions, cancer, diabetes. In particular, senescent cells produce inflammatory cytokines other pro-inflammatory molecules that participate diseases. Humanin, on hand, seems contrast known diseases promoting death damaged or malfunctioning contributing inflammation often associated with them. Both humanin-related mechanisms are complex have not fully clarified yet. Further research needed thoroughly understand disease identify potential interventions target them order prevent treat Objectives: This systematic review aims assess underlying link connecting senescence, humanin, disease.

Язык: Английский

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Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Antioxidants, Год журнала: 2024, Номер 13(3), С. 298 - 298

Опубликована: Фев. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Язык: Английский

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Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress

Nature Aging, Год журнала: 2024, Номер 4(7), С. 949 - 968

Опубликована: Июнь 25, 2024

Язык: Английский

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Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis

Molecules, Год журнала: 2024, Номер 29(9), С. 2050 - 2050

Опубликована: Апрель 29, 2024

Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response promote angiogenesis. Blood vessels play crucial role in sustaining vital life facilitating the delivery immune cells, oxygen, nutrients, as well eliminating waste products generated during cellular metabolism. Dysfunction blood may contribute significantly development life-threatening diseases. Anti-angiogenesis therapy pro-angiogenesis/angiogenesis strategies been frequently recommended various Herein, we describe mechanism which promotes angiogenesis summarize its application chronic wounds, bone repair, respiratory system. Furthermore, discuss drug system treating diseases, providing constructive ideas inspiration new treatment strategies.

Язык: Английский

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Role of iron in brain development, aging, and neurodegenerative diseases

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Март 4, 2025

It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.

Язык: Английский

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Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13680 - 13680

Опубликована: Сен. 5, 2023

Aging is a complex process influenced by genetics and the environment, leading to physiological decline increased susceptibility diseases. Cognitive prominent feature of aging, with implications for different neurodegenerative disorders. The gut microbiome has gained attention its potential impact on health disease, including cognitive function. This systematic review meta-analysis aimed investigate relationship between function in context aging. Following PRISMA guidelines, comprehensive search strategy was employed PubMed, Scopus, Web Science databases. Studies exploring role cognition disorders, published 2013 2023, were included. Data extraction quality assessment performed. Quantitative synthesis using statistical analyses performed examine microbial diversity relative abundance various conditions. Sixteen studies involving total 1303 participants included analysis. microbiota's individuals impairments such as Alzheimer's Parkinson's dementia, compared healthy controls. most prevalent phyla affected Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria. Meta-analyses indicated substantial heterogeneity among focusing disease. overall evidence related analysis moderate. microbiome's disorders warrants investigation. Altered abundance, particularly specific phyla, associated impairments. However, variations study findings methodologies highlight complexity Further are needed better understand mechanisms underlying this connection aging health.

Язык: Английский

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Decoding the Microbiome’s Influence on Rheumatoid Arthritis

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2170 - 2170

Опубликована: Авг. 28, 2023

The aim is better to understand and critically explore present the available data from observational studies on pathogenetic role of microbiome in development rheumatoid arthritis (RA). electronic databases PubMed, Scopus, Web Science were screened for relevant literature published last ten years. primary outcomes investigated included influence gut pathogenesis arthritis, exploring changes microbiota diversity relative abundance microbial taxa individuals with RA healthy controls (HCs). risk bias was assessed using GRADE criteria. Ten identified qualitative assessment. A total 647 represented literature, addition 16 psoriatic (PsA) 247 HCs. biospecimens comprised fecal samples across all 16S rDNA sequencing representing method biological analyses. Significant differences observed compared that HCs: a decrease Faecalibacterium, Fusicatenibacter, Enterococcus, Megamonas increases Eggerthellales, Collinsella, Prevotella copri, Klebsiella, Escherichia, Eisenbergiella, Flavobacterium. There are significant alterations This includes an increase copri Lactobacillus reductions Collinsella. Collectively, these proposed induce inflammatory responses degrade integrity intestinal barrier; however, further needed confirm this relationship.

Язык: Английский

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Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 11, 2024

Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function ferroptosis in aetiology development cancer other disorders. Consequently, harnessing for disease treatment has diverted interest researchers field basic clinical research. The ubiquitin-proteasome system (UPS) represents a primary protein degradation pathway eukaryotes. It involves labelling proteins be degraded ubiquitin (Ub), followed recognition proteasome. Dysfunction UPS can contribute diverse pathological processes, emphasizing importance maintaining organismal homeostasis. regulation stability critical component intricate molecular mechanism underlying death. Moreover, involvement regulating death-related molecules signaling pathways, providing valuable insights targeted strategies. Besides, it highlights potential as promising target therapy, combination between UPS. mechanisms ferroptosis, including key regulators such glutathione peroxidase 4 (GPX4), cysteine/glutamate transporter (system XC-), metabolism, are thoroughly examined, alongside role modulating abundance activity crucial ferroptotic death, GPX4, nuclear factor erythroid 2–related 2 (NRF2). As pivotal regulatory macromolecular homeostasis, substantially impacts directly or indirectly associated pathways. This review explores diseases with ferroptosis.

Язык: Английский

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