Pharmacological Research,
Год журнала:
2024,
Номер
208, С. 107370 - 107370
Опубликована: Авг. 23, 2024
Ferroptosis,
an
emerging
paradigm
of
programmed
cellular
necrosis
posited
in
recent
years,
manifests
across
a
spectrum
maladies
with
profound
implications
for
human
well-being.
Numerous
investigations
substantiate
that
modulating
ferroptosis,
whether
through
inhibition
or
augmentation,
plays
pivotal
role
the
etiology
and
control
numerous
age-related
afflictions,
encompassing
neurological,
circulatory,
respiratory,
other
disorders.
This
paper
not
only
summarizes
regulatory
mechanisms
but
also
discusses
impact
ferroptosis
on
biological
processes
aging
its
diseases.
Furthermore,
it
scrutinizes
therapeutic
strides
addressing
aging-related
conditions
modulation
ferroptosis.
The
consolidates
existing
knowledge
potential
applications
ferroptosis-related
pharmacotherapies
envisages
translational
prospects
ferroptosis-targeted
interventions
clinical
paradigms.
Environment International,
Год журнала:
2025,
Номер
197, С. 109361 - 109361
Опубликована: Март 1, 2025
Micro(nano)plastics
(MNPs),
are
emerging
environmental
pollutants
that
have
garnered
widespread
attention.
Epidemiological
and
animal
studies
shown
MNPs
exposure
during
pregnancy
is
associated
with
adverse
outcomes,
such
as
intrauterine
growth
restriction
(IUGR)
miscarriage.
However,
the
underlying
mechanisms
remain
poorly
understood.
In
this
study,
we
found
to
a
high
dose
(1
μg·mL-1)
of
100
nm
polystyrene
nanoparticles
(NPs)
from
gestational
day
(GD)
0
GD17
significantly
decreased
fetal
weight
increased
number
resorptions
compared
control
group.
Moreover,
was
lower
in
high-dose
group
than
low-dose
(0.1
Meanwhile,
ferroptosis
senescence
were
observed
placentas
mice
exposed
NPs.
vitro
experiments
using
human
syncytiotrophoblast
(STB)
cells
differentiated
BeWo
cells,
NPs
caused
STB
cells.
Subsequent
investigations
revealed
inhibition
signaling
by
ferrostain-1
(Fer-1)
or
deferiprone
(DFP)
ameliorated
induced
Furthermore,
alleviating
placental
Fer-1
improves
loss
mice.
Taken
together,
our
results
demonstrated
activated
pathway
STB,
resulting
which
may
attribute
NPs-induced
IUGR.
This
study
not
only
elucidated
mechanistic
link
between
outcomes
but
also
highlighted
necessity
for
targeted
interventions
protect
health,
underscoring
broader
implications
public
health
policy.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(7), С. 2102 - 2102
Опубликована: Апрель 3, 2024
Background:
Neurological
disorders,
particularly
those
associated
with
aging,
pose
significant
challenges
in
early
diagnosis
and
treatment.
The
identification
of
specific
biomarkers,
such
as
platelets
(PLTs),
has
emerged
a
promising
strategy
for
detection
intervention
neurological
health.
This
systematic
review
aims
to
explore
the
intricate
relationship
between
PLT
dynamics
health,
focusing
on
their
potential
role
cognitive
functions
pathogenesis
disorders.
Methods:
Adhering
PRISMA
guidelines,
comprehensive
search
was
employed
PubMed
Scholar
databases
identify
studies
PLTs
disorders
published
from
2013
2023.
criteria
included
biomarkers
dynamics,
monitoring
disease
progression
therapy
effectiveness.
Results:
104
studies,
revealing
crucial
neurocognitive
acting
inflammatory
mediators.
findings
suggest
that
share
common
features
altered
neurons,
which
could
be
utilised
evaluating
effectiveness
treatments.
are
identified
detecting
stages
understanding
pathological
events
leading
neuronal
death.
Conclusions:
underscores
critical
highlighting
progression.
However,
it
also
emphasises
need
further
research
solidify
use
aiming
enhance
strategies.
The
local
gingival
tissue
environment
with
homeostasis
and
tissue-destructive
events
of
periodontitis
demonstrates
major
changes
in
histological
features
biology
the
oral/sulcular
epithelium,
fibroblasts,
vascular
cells,
inflammatory
cell
infiltration,
alveolar
bone.
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 831 - 831
Опубликована: Июль 11, 2024
Vascular
aging
is
one
of
the
reasons
for
high
incidence
cardiovascular
diseases
nowadays,
as
vascular
cells
age
due
to
various
internal
and
external
factors.
Among
them,
fat
an
important
inducer.
Canagliflozin
(CAN)
SGLT2
inhibitors
that
has
been
shown
have
protective
effects
in
addition
lowering
blood
sugar,
but
specific
mechanism
not
clear.
This
study
first
established
a
model
using
palmitic
acid
(PA),
then
tested
effect
CAN
on
PA-induced
aging,
finally
examined
CAN's
anti-vascular
via
ROS/ERK
ferroptosis
pathways.
We
found
alleviates
cell
by
inhibiting
activation
signaling
reveals
new
mechanisms
lipid-induced
inhibition
from
perspectives
pathways,
which
expected
provide
ideas
development
related
drugs
future.
Pharmacological Research,
Год журнала:
2024,
Номер
208, С. 107370 - 107370
Опубликована: Авг. 23, 2024
Ferroptosis,
an
emerging
paradigm
of
programmed
cellular
necrosis
posited
in
recent
years,
manifests
across
a
spectrum
maladies
with
profound
implications
for
human
well-being.
Numerous
investigations
substantiate
that
modulating
ferroptosis,
whether
through
inhibition
or
augmentation,
plays
pivotal
role
the
etiology
and
control
numerous
age-related
afflictions,
encompassing
neurological,
circulatory,
respiratory,
other
disorders.
This
paper
not
only
summarizes
regulatory
mechanisms
but
also
discusses
impact
ferroptosis
on
biological
processes
aging
its
diseases.
Furthermore,
it
scrutinizes
therapeutic
strides
addressing
aging-related
conditions
modulation
ferroptosis.
The
consolidates
existing
knowledge
potential
applications
ferroptosis-related
pharmacotherapies
envisages
translational
prospects
ferroptosis-targeted
interventions
clinical
paradigms.
