Abstract
Research
on
serotonin
reveals
a
lack
of
consensus
regarding
its
role
in
brain
volume,
especially
concerning
biomarkers
linked
to
neurogenesis
and
neuroplasticity,
such
as
ciliary
neurotrophic
factor
(CNTF),
fibroblast
growth
4
(FGF-4),
bone
morphogenetic
protein
6
(BMP-6),
matrix
metalloproteinase-1
(MMP-1)
Alzheimer’s
disease
(AD).
This
study
aimed
investigate
the
influence
structure
hippocampal
volumes
relation
cognitive
functions
AD,
well
link
with
like
CNTF,
FGF-4,
BMP-6,
MMP-1.
Data
from
133
ADNI
participants
AD
included
assessments
(CDR-SB),
measurements
(Biocrates
AbsoluteIDQ
p180
kit,
UPLC-MS/MS),
factors
quantified
via
multiplex
proteomics.
Gray
matter
volume
changes
were
analyzed
using
Voxel-Based
Morphometry
(VBM)
MRI.
Statistical
analyses
employed
Pearson
correlation,
bootstrap
methods,
FDR-adjusted
p-values
(<
0.05
or
<
0.01)
Benjamini–Hochberg
procedure,
alongside
nonparametric
methods.
The
analysis
found
positive
correlation
between
levels
total
(r
=
0.229,
p
0.023)
(right:
r
0.186,
0.032;
left:
0.210,
0.023),
even
after
FDR
adjustment.
Higher
better
function
(negative
CDR-SB,
−0.230,
0.024).
Notably,
positively
correlated
BMP-6
0.173,
0.047),
CNTF
0.216,
0.013),
FGF-4
0.176,
0.043),
MMP-1
0.202,
0.019),
suggesting
neuroplasticity.
However,
adjusting
for
multiple
comparisons
controlling
confounding
age,
gender,
education,
APOE
genotypes
(APOE3
APOE4),
none
correlations
remained
statistically
significant.
In
conclusion,
increased
are
associated
improved
volume.
associations
not
significant
adjustments,
highlighting
complexity
serotonin’s
need
further
research.
Graphical
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14667 - 14667
Опубликована: Сен. 28, 2023
Ageing
is
inevitable
in
all
living
organisms
and
associated
with
physical
deterioration,
disease
eventually
death.
Dysbiosis,
which
the
alteration
of
gut
microbiome,
occurs
individuals
during
ageing,
plenty
studies
support
that
dysbiosis
responsible
for
progression
different
types
age-related
diseases.
The
economic
burden
age-linked
health
issues
increases
as
ageing
populations
increase.
Hence,
an
improvement
prevention
or
therapeutic
approaches
urgently
required.
In
recent
years,
vitamin
E
has
garnered
significant
attention
a
promising
approach
delaying
process
potentially
impeding
development
disease.
Nevertheless,
more
research
still
required
to
understand
how
affects
microbiome
it
relates
Therefore,
we
gathered
summarized
papers
this
review
addressed
impact
on
disease,
effect
along
role
relationship
diseases
are
caused
by
ageing.
Based
reported,
bacteria
brought
various
either
increased
decreased
relative
abundances.
Some
have
also
reported
positive
effects
beneficial
metabolites
increase
supplementation.
This
demonstrates
vital
positively
delay
findings
discussed
will
provide
simplified
yet
deeper
understanding
researchers
studying
diseases,
allowing
them
develop
new
preclinical
clinical
studies.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 5, 2024
Acoustic
stimuli
such
as
music
or
ambient
noise
can
significantly
affect
physiological
and
psychological
health
in
humans.
We
here
summarize
positive
effects
of
therapy
premature
infant
distress
regulation,
performance
enhancement,
sleep
quality
control,
treatment
mental
disorders.
Specifically,
exhibits
promising
on
neurological
disorders
Alzheimer's
disease
(AD)
Parkinson's
(PD).
also
highlight
regulatory
mechanisms
by
which
auditory
intervention
affects
an
organism,
encompassing
modulation
immune
responses,
gene
expression,
neurotransmitter
regulation
neural
circuitry.
As
a
safe,
cost-effective
non-invasive
intervention,
offers
substantial
potential
treating
variety
conditions.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Сен. 30, 2024
Postoperative
cognitive
dysfunction
(POCD)
poses
a
significant
threat
to
patients
undergoing
anesthesia
and
surgery,
particularly
elderly
patients.
It
is
characterized
by
diminished
functions
post
such
as
impaired
memory
decreased
concentration.
The
potential
risk
factors
for
POCD
include
age,
surgical
trauma,
anesthetic
type,
overall
health
condition;
however,
the
precise
mechanisms
underlying
remain
elusive.
Recent
studies
suggest
that
neuroinflammation
might
be
primary
pathogenic
factor.
NOD-,
LRR-
pyrin
domain-containing
protein
3
(NLRP3)
inflammasomes
are
implicated
in
exacerbating
promoting
release
of
inflammatory
proteins
initiate
pyroptosis,
further
influencing
disease
process.
regulation
NLRP3
inflammasome
activity,
including
its
activation
degradation,
tightly
controlled
through
multiple
pathways
mechanisms.
In
addition,
autophagy,
protective
mechanism,
regulates
control
progression
POCD.
This
review
reviews
recent
findings
on
role
pathogenesis
discusses
therapeutic
strategies
aimed
at
reducing
sources,
inhibiting
cellular
enhancing
autophagy.
Abstract
Research
on
serotonin
reveals
a
lack
of
consensus
regarding
its
role
in
brain
volume,
especially
concerning
biomarkers
linked
to
neurogenesis
and
neuroplasticity,
such
as
ciliary
neurotrophic
factor
(CNTF),
fibroblast
growth
4
(FGF-4),
bone
morphogenetic
protein
6
(BMP-6),
matrix
metalloproteinase-1
(MMP-1)
Alzheimer’s
disease
(AD).
This
study
aimed
investigate
the
influence
structure
hippocampal
volumes
relation
cognitive
functions
AD,
well
link
with
like
CNTF,
FGF-4,
BMP-6,
MMP-1.
Data
from
133
ADNI
participants
AD
included
assessments
(CDR-SB),
measurements
(Biocrates
AbsoluteIDQ
p180
kit,
UPLC-MS/MS),
factors
quantified
via
multiplex
proteomics.
Gray
matter
volume
changes
were
analyzed
using
Voxel-Based
Morphometry
(VBM)
MRI.
Statistical
analyses
employed
Pearson
correlation,
bootstrap
methods,
FDR-adjusted
p-values
(<
0.05
or
<
0.01)
Benjamini–Hochberg
procedure,
alongside
nonparametric
methods.
The
analysis
found
positive
correlation
between
levels
total
(r
=
0.229,
p
0.023)
(right:
r
0.186,
0.032;
left:
0.210,
0.023),
even
after
FDR
adjustment.
Higher
better
function
(negative
CDR-SB,
−0.230,
0.024).
Notably,
positively
correlated
BMP-6
0.173,
0.047),
CNTF
0.216,
0.013),
FGF-4
0.176,
0.043),
MMP-1
0.202,
0.019),
suggesting
neuroplasticity.
However,
adjusting
for
multiple
comparisons
controlling
confounding
age,
gender,
education,
APOE
genotypes
(APOE3
APOE4),
none
correlations
remained
statistically
significant.
In
conclusion,
increased
are
associated
improved
volume.
associations
not
significant
adjustments,
highlighting
complexity
serotonin’s
need
further
research.
Graphical
