Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 1190 - 1208
Опубликована: Ноя. 12, 2024
In
spite
of
multipurpose
technologies
offering
broad-spectrum
prevention
for
sexually
transmitted
infections
(STIs)
and
contraception,
the
STIs
incidences
rise
worldwide.
The
situation
is
even
more
alarming
considering
continuous
in
antimicrobial
resistance
(AMR)
that
limits
therapy
options.
this
review
we
address
specific
challenges
efficiently
treating
vaginal
locally,
at
infection
site,
by
understanding
underlying
barriers
to
efficient
treatment
such
as
biofilms.
Knowledge
on
biofilms
remains,
up
now,
rather
scarce
requires
attention.
We
therefore
propose
a
'back
basics'
insight
seeks
probe
complexity
role
microbiota,
its
relationship
with
implications
future
therapeutic
modalities
utilizing
advanced
nano
delivery
systems.
Our
key
objective
highlight
interplay
between
biofilm,
(nano)formulation
outcome
than
provide
an
overview
all
nanoformulations
were
challenged
against
focused
anatomy
female
reproductive
organ
physiological
changes
from
birth,
unique
microenvironment
premenopausal
postmenopausal
women,
biofilm
current
nanomedicine-based
approaches
treat
site.
Finally,
offer
our
perspectives
associated
considerations
can
aid
design
development
safer
potent
products
persisting
infections.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune
diseases
present
complex
therapeutic
challenges
due
to
their
chronic
nature,
systemic
impact,
and
requirement
for
precise
immunomodulation
avoid
adverse
side
effects.
Recent
advancements
in
biodegradable
stimuli-responsive
nanomaterials
have
opened
new
avenues
targeted
drug
delivery
systems
capable
of
addressing
these
challenges.
This
review
provides
a
comprehensive
analysis
state-of-the-art
nanocarriers
such
as
polymeric
nanoparticles,
liposomes,
hydrogels
engineered
autoimmune
therapies.
These
are
designed
degrade
safely
the
body
while
releasing
agents
response
specific
stimuli,
including
pH,
temperature,
redox
conditions,
enzymatic
activity.
By
achieving
localized
controlled
release
anti-inflammatory
immunosuppressive
agents,
minimize
toxicity
enhance
efficacy.
We
discuss
underlying
mechanisms
nanomaterials,
recent
applications
treating
rheumatoid
arthritis,
multiple
sclerosis,
inflammatory
bowel
disease,
design
considerations
essential
clinical
translation.
Additionally,
we
address
current
challenges,
biocompatibility,
scalability,
regulatory
hurdles,
well
future
directions
integrating
advanced
nanotechnology
with
personalized
medicine
treatment.
highlights
transformative
potential
presenting
them
promising
strategy
advance
precision
improve
patient
outcomes
disease
management.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25393 - e25393
Опубликована: Фев. 1, 2024
Chronic
Obstructive
Pulmonary
Disease
(COPD)
is
a
dilapidating
condition
which
characterized
by
inflammation,
an
excess
in
free
radical
generation
and
airway
obstruction.
Currently,
the
drugs
commercially
available
for
management
of
COPD
pose
several
limitations
such
as
systemic
adverse
effects,
including
bone
density
loss
increased
risk
developing
pneumonia.
Moreover,
another
limitation
includes
need
regular
frequent
dosing
regimens;
can
affect
adherence
to
therapy.
Furthermore,
these
current
treatments
provide
symptomatic
relief;
however,
they
cannot
stop
progression
COPD.
Comparatively,
nanoparticles
(NPs)
great
therapeutic
potential
treat
due
their
high
specificity,
biocompatibility,
higher
bioavailability.
NP-based
drug
delivery
systems
involve
less
requirements
smaller
doses
assist
minimizing
side
effects.
In
this
review,
benefits
conventional
therapies
are
explored,
while
providing
in-depth
insight
on
advanced
applications
treatment
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
95, С. 105564 - 105564
Опубликована: Март 12, 2024
The
nasal
route
has
routinely
been
used
in
the
local
delivery
of
drugs,
however
with
innovations
nanotechnology,
there
increased
interest
exploring
this
more
for
systemic,
and
brain/CNS
delivery.
This
is
because
safe,
non-invasive,
medications
can
be
self-administered
to
achieve
rapid
therapeutic
drug
levels
minimal
doses.
Polymeric
nanoparticles
(NPs)
such
as
PLGA
NPs
have
a
wide
range
applications
delivery,
due
their
large
surface
area
modification
targeting
ligands
polymers
which
enhances
cellular
uptake,
bioavailability
at
target
sites.
review
covers
recent
research
on
use
small
molecule
drugs
macromolecules
via
route.
It
some
background
information
about
challenges
delivering
most
common
polymer
coatings
are
highlighted.
Finally,
patents
clinical
trials
also
covered.
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
208, С. 115292 - 115292
Опубликована: Март 24, 2024
Vaccination
is
one
of
the
most
successful
measures
in
modern
medicine
to
combat
diseases,
especially
infectious
and
saves
millions
lives
every
year.
Vaccine
design
development
remains
critical
involves
many
aspects,
including
choice
platform,
antigen,
adjuvant,
route
administration.
Topical
vaccination,
defined
herein
as
introduction
a
vaccine
any
three
layers
human
skin,
has
attracted
interest
recent
years
an
alternative
vaccination
approach
conventional
intramuscular
administration
because
its
potential
be
needle-free
induce
superior
immune
response
against
pathogens.
In
this
review,
we
describe
progress
developing
topical
vaccines,
highlight
delivery
technologies
for
discuss
factors
that
might
impact
efficacy,
provide
overview
current
clinical
landscape
vaccines.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 88 - 88
Опубликована: Янв. 9, 2024
Clinical
drug
administration
aims
to
deliver
drugs
efficiently
and
safely
target
tissues,
organs,
cells,
with
the
objective
of
enabling
their
therapeutic
effects.
Currently,
main
approach
enhance
a
drug’s
effectiveness
is
ensuring
its
efficient
delivery
intended
site.
Due
fact
that
there
are
still
various
drawbacks
traditional
methods,
such
as
high
toxicity
side
effects,
insufficient
specificity,
poor
targeting,
pharmacokinetic
performance,
nanocarriers
have
emerged
promising
alternative.
Nanocarriers
possess
significant
advantages
in
due
size
tunability
surface
modifiability.
Moreover,
nano-drug
systems
demonstrated
strong
potential
terms
prolonging
circulation
time,
improving
bioavailability,
increasing
retention
at
tumor
site,
decreasing
resistance,
well
reducing
undesirable
effects
anticancer
drugs.
Numerous
studies
focused
on
utilizing
polysaccharides
nanodelivery
carriers,
developing
based
polysaccharides,
or
exploiting
tumor-targeting
ligands
precision
nanoparticle
delivery.
These
types
investigations
become
commonplace
academic
literature.
This
review
elucidate
preparation
methods
principles
polysaccharide
gold
nanocarriers.
It
also
provides
an
overview
factors
affect
loading
different
kinds
Additionally,
it
outlines
strategies
employed
by
improve
efficiency
The
provide
reference
for
further
development
research
systems.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(2), С. 170 - 170
Опубликована: Янв. 29, 2024
Bone
tuberculosis,
an
extrapulmonary
manifestation
of
presents
unique
treatment
challenges,
including
its
insidious
onset
and
complex
pathology.
While
advancements
in
anti-tubercular
therapy
have
been
made,
the
efficacy
is
often
limited
by
difficulties
achieving
targeted
drug
concentrations
avoiding
systemic
toxicity.
The
intricate
bone
structure
presence
granulomas
further
impede
effective
delivery.
Nano-drug
delivery
systems
emerged
as
a
promising
alternative,
offering
enhanced
targeting
drugs.
These
systems,
characterized
their
minute
size
adaptable
surface
properties,
can
be
tailored
to
improve
solubility,
stability,
bioavailability,
while
also
responding
specific
stimuli
within
TB
microenvironment
for
controlled
release.
encapsulate
drugs
precise
infection
site.
A
significant
innovation
integration
with
prosthetics
or
biomaterials,
which
aids
both
reconstruction,
addressing
osteological
consequences.
This
review
provides
comprehensive
overview
pathophysiology
tuberculosis
current
treatments,
emphasizing
limitations.
It
then
delves
into
nano-drug
discussing
design,
functionality,
role
therapy.
assesses
potential
preclinical
research,
particularly
delivery,
efficacy,
reduction
side
effects.
Finally,
it
highlights
transformative
promise
nanotechnology
treatments
suggests
future
research
directions
this
evolving
field.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 10, 2024
As
a
common
musculoskeletal
disorder,
frozen
shoulder
is
characterized
by
thickened
joint
capsule
and
limited
range
of
motion,
affecting
2-5%
the
general
population
more
than
20%
patients
with
diabetes
mellitus.
Pathologically,
fibrosis
resulting
from
fibroblast
activation
key
event.
The
activated
fibroblasts
are
proliferative
contractive,
producing
excessive
collagen.
Albeit
high
prevalence,
effective
anti-fibrosis
modalities,
especially
fibroblast-targeting
therapies,
still
lacking.
In
this
study,
microRNA-122
was
first
identified
sequencing
data
as
potential
therapeutic
agent
to
antagonize
activation.
Then,
Agomir-122,
an
analog
microRNA-122,
loaded
into
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(Agomir-122@NP),
carrier
excellent
biocompatibility
for
delivery.
Moreover,
relying
on
homologous
targeting
effect,
we
coated
Agomir-122@NP
cell
membrane
derived
(Agomir-122@MNP),
attempt
inhibit
proliferation,
contraction,
collagen
production
abnormally
fibroblasts.
After
confirming
effect
Agomir-122@MNP
in
vitro,
proved
that
effectively
curtailed
activation,
ameliorated
fibrosis,
restored
motion
mouse
models
both
prophylactically
therapeutically.
Overall,
targeted
delivery
method
developed
promising
translational
value
against
shoulder.
Applied Sciences,
Год журнала:
2025,
Номер
15(1), С. 468 - 468
Опубликована: Янв. 6, 2025
The
development
of
anticancer
drugs
is
costly
and
time
intensive.
Computational
approaches
optimize
the
process
by
studying
molecules
such
as
naphthoquinones.
This
research
explores
quantitative
structure–activity
relationship
(QSPR)
molecular
interactions
among
2,2-dimethyl-3-((3-nitrophenyl)amino)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
(QPhNO2),
a
Nor-β-Lapachone
derivative
with
properties,
following
polymers
for
nanoencapsulation:
polymethyl
methacrylate
(PMMA),
polycaprolactone
(PCL),
poly-lactic-co-glycolic
acid
(PLGA).
Spartan
14
optimized
compounds
using
density
functional
theory
(DFT),
while
ArgusLab
performed
docking,
Discovery
Studio
analyzed
post-docking
results.
Simulations
indicated
that
larger
energy
gaps
are
more
stable
less
prone
to
deformation
than
QPhNO2,
facilitating
interaction
polymer
chains.
binding
energies
PMMA/QPhNO2,
PCL/QPhNO2,
PLGA/QPhNO2
were
−4.607,
−4.437,
−1.814
kcal/mol,
respectively.
Docking
analysis
revealed
non-bonded
between
QPhNO2.
These
findings
highlight
role
computational
methods
in
nanoencapsulation
characterization,
guiding
future
analogs
combinations.
