Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment DOI Creative Commons

Dayong Li,

Xujie Zhang,

Yuru Lu

и другие.

Neurological Sciences, Год журнала: 2024, Номер 45(7), С. 3093 - 3105

Опубликована: Фев. 21, 2024

Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in marked increase long-term mortality among affected patients. Regrettably, impairment associated with sepsis frequently disregarded by clinicians. This review aims summarize recent advancements the understanding of pathophysiology, prevention, treatment post-sepsis mental including coronavirus disease 2019-related impairment. The pathophysiology complex known involve blood-brain barrier disruption, overactivation hypothalamic-pituitary-adrenal axis, neuroinflammation, oxidative stress, neurotransmitter dysfunction, programmed cell death, impaired neuroplasticity. No unified diagnostic criteria for this are currently available; however, screening scales often applied its assessment. Modifiable risk factors include number experienced traumatic memories, length ICU stay, level albumin, use vasopressors or inotropes, daily activity function after cumulative dose dobutamine. To contribute prevention it may be beneficial implement targeted interventions these modifiable factors. Specific therapies condition remain scarce. Nevertheless, non-pharmacological approaches, such as comprehensive nursing care, provide promising avenue treating following sepsis. In addition, although several therapeutic drugs have shown preliminary efficacy animal models, further confirmation their potential required through follow-up clinical studies.

Язык: Английский

Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis DOI Creative Commons
Qian Zhang, Yi Zhao,

Long Fei Li

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1207 - 1233

Опубликована: Янв. 1, 2025

Osteoarthritis (OA) affects several joints but tends to be more prevalent in those that are weight-bearing, such as the knees, which most heavily loaded body. The incidence and disability rates of OA have continued increase seriously jeopardise quality life middle-aged older adults. However, is than just a wear tear disease; its aetiology complex, pathogenesis poorly understood. Metabolic syndrome (MetS) has emerged critical driver development. This condition contributes formation distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by unique pathophysiological mechanisms clinical presentation. As key mediators MetS, adipokines leptin, lipocalin, resistin regulate inflammation bone metabolism through or synergistic signaling pathways. Their modulation inflammatory responses remodeling processes plays role progression OA. Due their central regulating remodeling, not only deepen our understanding MetS-OA also represent promising targets for novel therapeutic strategies could slow disease improve outcomes affected patients.

Язык: Английский

Процитировано

2
Glycolysis: an emerging regulator of osteoarthritis DOI Creative Commons

Dingming Jiang,

Jianan Guo,

Yingquan Liu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

Osteoarthritis (OA) has been a leading cause of disability in the elderly and there remains lack effective therapeutic approaches as mechanisms pathogenesis progression have yet to be elucidated. As OA progresses, cellular metabolic profiles energy production are altered, emerging reprogramming highlights importance specific pathways disease progression. crucial part glucose metabolism, glycolysis bridges inflammatory dysfunctions. Moreover, glycolytic pathway is involved different areas metabolism inflammation, associated with variety transcription factors. To date, it not fully elucidated whether changes its key enzymes onset or OA. This review summarizes important role mediating inducing tissue inflammation injury, aim providing further insights into pathological functions proposing new targets for treatment

Язык: Английский

Процитировано

11
Zooming in and Out of Programmed Cell Death in Osteoarthritis: A Scientometric and Visualized Analysis DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 2479 - 2498

Опубликована: Апрель 1, 2024

During the past decade, mounting evidence has increasingly linked programmed cell death (PCD) to progression and development of osteoarthritis (OA).There is a significant need for thorough scientometric analysis that recapitulates relationship between PCD OA.This study aimed collect articles reviews focusing on in OA, extracting data from January 1st, 2013, October 31st, 2023, using Web Science.Various tools, including VOSviewer, CiteSpace, Pajek, Scimago Graphica, R package, were employed visualization analyses.Notably, China, USA, South Korea emerged as major contributors, collectively responsible more than 85% published papers significantly influencing research this field.Among different institutions, Shanghai Jiao Tong University, Xi'an Zhejiang University exhibited highest productivity.Prolific authors included Wang Wei, Jing, Zhang Li

Язык: Английский

Процитировано

11
Curcumin-loaded biomimetic nanosponges for osteoarthritis alleviation by synergistically suppressing inflammation and ferroptosis DOI
Huihui Xu, Su Liu, Yihao Wei

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 491, С. 152132 - 152132

Опубликована: Май 10, 2024

Язык: Английский

Процитировано

11
Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics DOI Creative Commons
Seyede Sara Pakdaman Kolour,

Saeide Nematollahi,

Masoud Dehbozorgi

и другие.

Heliyon, Год журнала: 2025, Номер unknown, С. e42258 - e42258

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Recent advances in natural compounds inducing non-apoptotic cell death for anticancer drug resistance DOI Open Access
Jiawen Chen, Sibao Chen, Guoqing Chen

и другие.

Cancer Drug Resistance, Год журнала: 2023, Номер 6(4), С. 709 - 27

Опубликована: Окт. 16, 2023

The induction of cell death is recognized as a potent strategy for cancer treatment. Apoptosis an extensively studied form death, and multiple anticancer drugs exert their therapeutic effects by inducing it. Nonetheless, apoptosis evasion hallmark cancer, rendering cells resistant to chemotherapy drugs. Consequently, there growing interest in exploring novel non-apoptotic forms such ferroptosis, necroptosis, pyroptosis, paraptosis. Natural compounds with properties have garnered significant attention due advantages, including reduced risk drug resistance. Over the past two decades, numerous natural been discovered anti-resistance triggering these four mechanisms. This review primarily focuses on mechanisms recent advancements overcoming resistance Meanwhile, it highlights role effectively addressing through death.

Язык: Английский

Процитировано

17
Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression DOI Creative Commons

Chenxiao Zheng,

Jiayi Chen, Yurui Wu

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июнь 9, 2023

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type post-translational modifications, has been demonstrated to accelerate or ameliorate the development and progression via targeting specific proteins for ubiquitination determining protein stability localization. Ubiquitination process can be reversed by a class deubiquitinases deubiquitination. In this review, we summarize current knowledge regarding multifaceted role E3 ubiquitin ligases pathogenesis osteoarthritis. We also describe insight into processes. Moreover, highlight multiple compounds that target influence progression. discuss challenge future perspectives modulation expression enhancement therapeutic efficacy patients. conclude modulating deubiquitination could alleviate achieve better treatment outcomes

Язык: Английский

Процитировано

12
NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics DOI Creative Commons
Yuzhou Liu, Ying Wang,

Ping Yan

и другие.

Biology, Год журнала: 2025, Номер 14(1), С. 71 - 71

Опубликована: Янв. 14, 2025

The prevalence of osteoarthritis (OA) notably surges with age and weight gain. most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course OA. Thus, understanding OA's pathogenesis devising effective therapies is crucial. It generally recognized that inflammation, pyroptosis, OA progression tightly linked. activation NLRP3 inflammasome can lead to discharge pro-inflammatory cytokines Interleukin-1β IL-18, intensifying subsequent inflammatory reactions promoting development. Conversely, imbalance caused by deacetylase-regulated underlies chronic mild inflammation related degenerative diseases. Therefore, this article expounds on mechanism role histone deacetylases (HDACs) in inflammasome-triggered OA, illustrates application HDAC inhibitors striving provide more insights into novel treatment approaches.

Язык: Английский

Процитировано

0
Coixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes DOI
Liqin Zhang, Guangping Zheng, Weicheng Zhao

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Osteoarthritis (OA) is a chronic multifactorial disease characterized by cartilage degeneration, pain, and reduced mobility. Current therapies primarily aim to relieve pain restore function, but they often have limited effectiveness side effects. Coixol, bioactive compound from Coix lacryma-jobi L., exhibits anti-inflammatory analgesic properties, suggesting potential benefits in OA treatment. This study explored the effects of coixol on chondrocytes. Primary chondrocytes rats were isolated treated with varying concentrations coixol. Cell viability proliferation assessed using CCK-8 assays. The expression genes related ferroptosis autophagy was analyzed through RT-qPCR, Western blot, immunofluorescence. Moreover, investigated characteristics performance coixol-loaded PDLLA–PEG-PDLLA (PLEL)/gelatin sponge (GS) hydrogels (Coixol@PLEL/GS) for enhancing osteochondral defect repair specifically targeting chondrocyte autophagy. PDLLA–PEG-PDLLA/gelatin evaluated cryo-scanning electron microscopy (SEM) or SEM, release kinetics determined. In vivo, rat model used assess efficacy Coixol@PLEL/GS International Cartilage Repair Society (ICRS) scores, Safranin O/Fast green staining, Toluidine blue Coixol significantly increased dose-dependent manner. Furthermore, inhibited stimulated autophagy, as evidenced upregulation genes. remarkably enhanced defects compared that control groups. conclusion, protects improving survival, inhibiting ferroptosis, activating highlighting its therapeutic strategy

Язык: Английский

Процитировано

0
Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data DOI Creative Commons

JiangFei Zhou,

Songsong Jiao,

Jian Huang

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 751 - 778

Опубликована: Янв. 1, 2025

Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. Diverse programmed cell death (PCD) pathways are closely linked to pathogenesis OA, but few studies have explored relationship between PCD-related genes and synovitis. The transcriptome expression profiles OA synovial samples were obtained from Gene Expression Omnibus (GEO) database. Using machine learning algorithms, Hub differentially expressed (Hub PCD-DEGs) identified. PCD-DEGs was validated in human by qRT-PCR. A diagnostic model for constructed based on levels PCD-DEGs. Unsupervised consensus clustering analysis weighted correlation network (WGCNA) employed identify differential patterns patients. molecular characteristics PCD-DEGs, their role immune inflammation, association with microenvironment investigated through functional enrichment ssGSEA infiltration analysis. Single-cell RNA sequencing provided insights into distinct clusters tissues interactions We identified five PCD-DEGs: TNFAIP3, JUN, PPP1R15A, INHBB, DDIT4. qRT-PCR confirmed that all significantly downregulated tissue. these demonstrated efficiency distinguishing as well progression OA. Additionally, a observed infiltration, inflammatory cytokine levels. two PCD clusters, each exhibiting unique immunological characteristics. further revealed dynamic complex cellular changes tissue, across various types. Our study suggests may be involved development screened (TNFAIP3, INHBB DDIT4) could candidate biomarkers or therapeutic targets

Язык: Английский

Процитировано

0