International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11241 - 11241
Опубликована: Окт. 19, 2024
Traumatic
brain
injury
(TBI),
a
major
cause
of
death
and
disability
among
young
people,
leads
to
significant
public
health
economic
challenges.
Despite
its
frequency,
treatment
options
remain
largely
unsuitable.
However,
examination
the
blood–brain
barrier
(BBB)
can
assist
with
understanding
mechanisms
dynamics
dysfunction,
which
affects
TBI
sufferers
secondarily
injury.
Here,
we
present
rat
model
focused
on
two
standard
BBB
assessment
markers,
high-
low-molecular-weight
complexes,
in
order
understand
disruption.
In
addition,
tested
new
technique
evaluate
disruption
single
set,
comparing
neuroimaging.
A
total
100
Sprague–Dawley
rats
were
separated
into
following
five
groups:
naive
(n
=
20
rats),
control
administration
60
rats).
Rats
assessed
at
different
time
points
after
measure
using
low-
high-molecular-weight
complexes.
Neurological
severity
score
was
evaluated
baseline
24
h
TBI.
During
neurological
exam
TBI,
scanned
magnetic
resonance
imaging
euthanized
for
permeability.
We
found
that
markers
displayed
examples
same
set
tissues
over
period
week.
Our
innovative
protocol
assessing
permeability
complexes
showed
appropriate
results.
Additionally,
determined
lower
limit
sensitivity,
therefore
demonstrating
accuracy
this
method.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Fluids and Barriers of the CNS,
Год журнала:
2024,
Номер
21(1)
Опубликована: Авг. 7, 2024
Cognitive
decline
covers
a
broad
spectrum
of
disorders,
not
only
resulting
from
brain
diseases
but
also
systemic
diseases,
which
seriously
influence
the
quality
life
and
expectancy
patients.
As
highly
selective
anatomical
functional
interface
between
circulation,
blood-brain
barrier
(BBB)
plays
pivotal
role
in
maintaining
homeostasis
normal
function.
The
pathogenesis
underlying
cognitive
may
vary,
nevertheless,
accumulating
evidences
support
BBB
disruption
as
most
prevalent
contributing
factor.
This
mainly
be
attributed
to
inflammation,
metabolic
dysfunction,
cell
senescence,
oxidative/nitrosative
stress
excitotoxicity.
However,
direct
evidence
showing
that
causes
is
scarce,
interestingly,
manipulation
opening
alone
exert
beneficial
or
detrimental
neurological
effects.
A
overview
present
literature
shows
close
relationship
decline,
risk
factors
disruption,
well
cellular
molecular
mechanisms
disruption.
Additionally,
we
discussed
possible
leading
by
potential
therapeutic
strategies
prevent
enhance
repair.
review
aims
foster
more
investigations
on
early
diagnosis,
effective
therapeutics,
rapid
restoration
against
would
yield
better
outcomes
patients
with
dysregulated
function,
although
their
causative
has
yet
been
completely
established.
Nutrients,
Год журнала:
2024,
Номер
16(6), С. 901 - 901
Опубликована: Март 21, 2024
There
is
a
growing
body
of
evidence
that
suggests
connection
between
traumatic
brain
injury
(TBI)
and
subsequent
post-traumatic
stress
disorder
(PTSD).
While
the
exact
mechanism
unknown,
we
hypothesize
chronic
glutamate
neurotoxicity
may
play
role.
The
consumption
dietary
modifiable
factor
influencing
levels
in
blood
and,
therefore,
brain.
In
this
systematic
review,
explored
relationship
development
post-TBI
PTSD.
Of
1748
articles
identified,
44
met
inclusion
criteria
for
analysis
review.
We
observed
individuals
from
countries
with
diets
traditionally
high
had
greater
odds
developing
PTSD
after
TBI
(odds
ratio
=
15.2,
95%
confidence
interval
11.69
to
19.76,
p
<
0.01).
These
findings
support
hypothesis
chronically
elevated
concentrations
caused
by
intake
invoke
neurodegeneration
processes
could
ultimately
result
Further
studies
will
clarify
whether
lowering
via
diet
would
be
an
effective
strategy
preventing
or
treating
Nutrients,
Год журнала:
2023,
Номер
15(21), С. 4681 - 4681
Опубликована: Ноя. 4, 2023
Traumatic
brain
injury
(TBI)
has
a
profound
impact
on
cognitive
and
mental
functioning,
leading
to
lifelong
impairment
significantly
diminishing
the
quality
of
life
for
affected
individuals.
A
healthy
blood-brain
barrier
(BBB)
plays
crucial
role
in
guarding
against
elevated
levels
blood
glutamate,
making
its
permeability
vital
aspect
glutamate
regulation
within
brain.
Studies
have
shown
efficacy
reducing
excess
as
treatment
post-TBI
depression,
anxiety,
aggression.
The
purpose
this
article
is
evaluate
involvement
dietary
development
depression
after
TBI.
We
performed
literature
search
examine
effects
diets
abundant
which
are
common
Asian
populations,
when
compared
low
prevalent
Europe
America.
specifically
explored
these
context
chronic
BBB
damage
TBI,
may
initiate
neurodegeneration
subsequently
an
through
mechanism
neurotoxicity.
glutamate-rich
diet
leads
increased
contrasted
with
glutamate-poor
diet.
Within
disruption,
translate
heightened
concentrations,
thereby
intensifying
due
Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 31, 2025
Traumatic
brain
injury
(TBI)
is
a
significant
global
health
concern
and
associated
with
short-term
long-term
comorbidities
such
as
mood
disorders
reduced
quality
of
life.
Diffuse
axonal
(DABI)
common
but
severe
type
TBI.
The
role
DABI
in
the
development
psychiatric
sequelae
after
TBI
not
well
understood
due
to
challenge
isolating
from
general
human
population.
Here
we
investigate
occurrence
post-TBI
depressive-
anxiety-like
behaviors
rat
model.
Forty
rats
were
randomly
assigned
two
groups,
20
receiving
sham
treatment.
We
used
magnetic
resonance
imaging
(MRI)
protocol
developed
for
using
3-T
clinical
scanner
confirm
DABI.
then
compared
neuroimaging,
neurological
behavioral
assessments
across
experimental
groups.
There
was
difference
between
groups
on
sucrose
preference,
measurement
depressive-like
behavior
(p
<
0.012),
time
spent
open
arms
plus
maze
test,
0.032).
For
MRI-detected
injury,
there
diffusion-weighted
relative
anisotropy
0.001)
fractional
mapping.
found
that
isolated
our
model
led
post-traumatic
30%
cases
35%.
Additionally,
established
diagnostic
cut-offs
injured
rats.
also
documented
comorbidity
depression
anxiety
DABI-exposed
anticipate
this
study
will
greatly
enhance
understanding
relationship
DABI,
TBI,
like
anxiety,
aid
developing
treatment
options
these
interconnected
conditions.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2294 - 2294
Опубликована: Фев. 15, 2024
Given
its
polygenic
nature,
there
is
a
need
for
personalized
approach
to
schizophrenia.
The
aim
of
the
study
was
select
laboratory
biomarkers
from
blood,
brain
imaging,
and
clinical
assessment,
with
an
emphasis
on
patients’
self-report
questionnaires.
Metabolomics
studies
serum
samples
51
patients
45
healthy
volunteers,
based
liquid
chromatography-electrospray
ionization-mass
spectrometry
(LC-ESI-MS/MS),
led
identification
3
biochemical
indicators
(cortisol,
glutamate,
lactate)
These
metabolites
were
sequentially
correlated
tests
results,
imaging
assessment
outcomes,
including
patient
outcomes.
hierarchical
cluster
analysis
principal
components
(HCPC)
performed
identify
most
homogeneous
groups.
Significant
correlations
noted
between
blood
lactates
11
10
neuroimaging
parameters.
increase
in
lactate
cortisol
significantly
associated
decrease
immunological
parameters,
especially
level
reactive
lymphocytes.
strongest
demonstrated
by
N-acetylaspartate
concentrations
glutamate
glutamine,
creatine
phosphocreatine
prefrontal
cortex.
search
associations
parameters
self-reported
outcomes
may
provide
new
diagnostic
evidence
specific
schizophrenia
phenotypes.
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4405 - 4405
Опубликована: Дек. 22, 2024
The
gut–brain
axis
plays
an
integral
role
in
maintaining
overall
health,
with
growing
evidence
suggesting
its
impact
on
the
development
of
various
neuropsychiatric
disorders,
including
depression.
This
review
explores
complex
relationship
between
gut
microbiota
and
glutamate
(Glu)
regulation,
highlighting
effect
brain
particularly
context
depression
following
certain
neurological
insults.
We
discuss
how
microbial
populations
can
either
facilitate
or
limit
Glu
uptake,
influencing
bioavailability
predisposing
to
neuroinflammation
neurotoxicity.
Additionally,
we
examine
metabolites
their
influence
blood–brain
barrier
neurotransmitter
systems
involved
mood
regulation.
therapeutic
potential
microbiome-targeted
interventions,
such
as
fecal
transplantation,
is
also
highlighted.
While
much
research
has
explored
major
depressive
disorders
other
diseases,
contribution
post-neurological
remains
underexplored.
Future
should
focus
explaining
mechanisms
linking
outcomes,
conditions
post-stroke
depression,
post-traumatic
brain-injury
epilepsy-associated
Systematic
reviews
human
clinical
studies
are
needed
establish
causal
relationships
assess
efficacy
therapies
improving
sequalae
after
