Journal of Advances in Biology & Biotechnology,
Год журнала:
2024,
Номер
27(12), С. 70 - 94
Опубликована: Дек. 10, 2024
Selenium
biofortification
aims
to
increase
selenium
accumulation
or
bioavailability
in
edible
crops,
tackling
the
global
issue
of
hidden
hunger
for
essential
micronutrients.
This
review
examines
vital
role
human
health,
its
interactions
within
soil-crop
systems,
and
potential
alleviate
abiotic
stresses
plants.
By
utilizing
selenorhizobacteria
as
biotechnological
tools,
presents
an
innovative
method
enhancing
crop
nutrition
quality.
The
emphasizes
key
mechanisms
involved
uptake,
function
activating
plant
antioxidant
dual
both
a
beneficial
nutrient
prooxidant.
Furthermore,
it
explores
microbial
contributions
mobility
bioavailability,
offering
practical
strategies
bolster
resilience
productivity.
comprehensive
analysis
highlights
importance
fostering
sustainable
agriculture
improving
health
outcomes.
Graphical
Abstract
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 10, 2024
Impaired
intestinal
homeostasis
is
a
major
pathological
feature
of
inflammatory
bowel
diseases
(IBD).
Mannose
and
selenium
(Se)
both
demonstrate
potential
anti-inflammatory
anti-oxidative
properties.
However,
most
lectin
receptors
bind
free
monosaccharide
ligands
with
relatively
low
affinity
Se
species
induce
side
effects
beyond
very
narrow
range
dosage.
This
has
contributed
to
poorly
explored
therapies
for
IBD
that
combine
mannose
target
epithelial
cells
(IECs)
normalization
gut
homeostasis.
Herein,
facile
safe
strategy
ulcerative
colitis
(UC)
treatment
was
developed
using
optimized,
mannose-functionalized
nanoparticles
(M-SeNPs)
encapsulated
within
colon-targeted
hydrogel
delivery
system
containing
alginate
(SA)
chitosan
(CS).
biocompatible
nanosystem
efficiently
taken
up
by
IECs
led
increased
expression
Se-dependent
glutathione
peroxidases
(GPXs),
thereby
modulating
IECs'
immune
response.
Using
mouse
model
DSS-induced
colitis,
(CS/SA)-embedding
M-SeNPs
(C/S-MSe)
were
found
mitigate
oxidative
stress
inflammation
through
the
inhibition
NF-kB
pathway
in
colon.
stabilized
mucosal
ameliorated
colitis-related
symptoms,
providing
new
approach
IBD.
Applied Sciences,
Год журнала:
2024,
Номер
14(18), С. 8513 - 8513
Опубликована: Сен. 21, 2024
This
research
paper
provides
a
comprehensive
overview
of
the
use
layered
double
hydroxides
(LDH)
in
removal
selenium
species
from
contaminated
water
sources.
Key
studies
on
sorption
mechanisms
and
impact
competing
ions
are
presented,
effectiveness
LDH
is
compared
across
different
structures
compositions.
Scholarly
sources
extensively
document
application
conventional
for
effective
removal,
with
notable
advancements
achieved
through
innovative
synthesis
approaches.
Comparative
between
synthesized
various
methods
reveal
potential
tailored
enhanced
adsorption.
The
further
explores
influence
anions
efficacy,
emphasizing
sulfate
removal.
Additionally,
investigations
into
calcined
commercially
available
variants
underscore
industrial
applications.
Beyond
LDH,
delves
iron-based
intercalated
thiomolybdate
anions,
rare
earth
hydroxides,
exploring
their
separating
species.
role
pH
three-metal
cation
also
discussed.
study
extends
to
nanocomposites,
combining
zero-valent
iron,
carbon-based
materials,
organic
compounds,
illustrating
immobilization.
presented
findings
offer
valuable
insights
researchers
practitioners
environmental
science,
addressing
growing
demand
efficient
remediation
strategies.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
life-threatening
disease
with
global
impact,
underscoring
the
urgent
need
for
development
of
new
therapeutic
agents.
This
study
evaluates
effect
selenium-hydroxytyrosol
nanoparticles
(Se-HTNPs)
in
rat
model
HCC
induced
by
diethylnitrosamine
(DEN).
In
vitro,
Se-HTNPs
treatment
reduced
viability
Hep
G2
cells
dose-dependent
manner,
an
IC50
value
61.29
±
1.12
µg/mL.
The
results
confirmed
antioxidant,
anti-inflammatory,
and
anti-carcinogenic
properties
Se-HTNPs,
demonstrating
their
effectiveness
against
DEN-induced
HCC.
effects
were
validated
inhibiting
serum
ALT,
AST,
ALP
enzyme
activities
reducing
total
bilirubin
levels.
Simultaneously,
enhanced
albumin
protein
Additionally,
alleviated
oxidative
stress
significantly
lowering
hepatic
lipid
peroxidation
(MDA)
levels
markedly
increasing
antioxidant
marker
(GSH,
SOD,
TAC)
compared
to
DEN-administered
rats.
also
inflammatory
markers
(TNFα,
IL-6,
IL-1β),
apoptotic
(p53
caspase
3),
VEGF
Furthermore,
DEN
group,
distinctly
suppressed
c-JNK
mRNA
NF-κB
gene
expression
Moreover,
Se-HTNP
improved
histological
alterations
DEN.
conclusion,
these
findings
suggest
that
mitigate
rats
through
potent
properties.
Journal of Oral Biology and Craniofacial Research,
Год журнала:
2025,
Номер
15(1), С. 199 - 204
Опубликована: Янв. 1, 2025
This
study
compared
the
drug
release
kinetics
of
Terminalia
arjuna
mediated
selenium
nanoparticles
(SeNPs)
gel
and
zinc
oxide
(ZnONPs)
for
their
potential
in
local
delivery
chronic
periodontitis.
The
was
evaluated
in-vitro
by
conducting
tests
on
different
formulations,
including
1
%,
2
3
4
5
%
SeNPs
ZnONPs
gel.
Each
sample,
approximately
0.1
mg,
mixed
with
10
mL
phosphate
buffer
saline
(PBS)
at
various
pH
levels
maintained
37
°C.
suspension
then
placed
an
incubated
shaker
120
rpm
h.
Five-milliliter
samples
were
withdrawn
from
dissolution
medium
30-min
intervals
replaced
fresh
PBS
to
maintain
a
constant
volume.
released
amount
measured
using
UV
spectrophotometer
(Systronics,
India)
290
nm.
investigation
revealed
that
exhibited
higher
percentages
across
concentrations
time
points.
sustained
profiles
both
formulations
suggest
effective
control
over
release,
maintaining
therapeutic
extended
period.
near-complete
500
min
highlights
prolonged
efficacy,
reducing
need
frequent
dosing
enhancing
patient
compliance.
shows
promise
more
rapid
management
periodontitis
through
systems.
Zeitschrift für Naturforschung C,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Abstract
Biogenic
selenium
nanoparticles
(SeNPs)
have
emerged
as
promising
area
of
research
due
to
their
unique
properties
and
potential
multifaceted
applications.
The
biosynthesis
SeNPs
through
biological
methods,
such
using
microorganism,
plant
extracts,
etc.,
offers
a
safe,
eco-friendly,
biocompatible
approach,
compared
traditional
chemical
synthesis.
Recent
several
studies
demonstrated
that
application
includes
broad
antibacterial,
anticancer,
antioxidant,
antiviral,
anti-inflammatory,
antidiabetic,
excellent
wound
healing
activity.
On
the
other
hand,
also
shown
in
sensing
inorganic
toxic
metals,
electrochemistry,
agro-industries,
aqua-cultures,
fabrication
solar
panels.
Additionally,
capability
enhance
efficacy
antibiotics
act
effective
agents
against
multidrug-resistant
pathogens
has
addressing
critical
health
challenges.
Although,
exhibit
wide
applicability,
toxicity
Se,
particularly
its
various
oxidative
states,
necessitates
careful
assessment
environmental
impacts
associated
with
use.
Therefore,
understanding
balance
between
beneficial
risks
is
crucial
for
safe
This
review
focuses
exclusively
on
synthesized
via
eco-friendly
process,
excluding
utilizing
synthesis
processes.
Moreover,
this
aims
offer
an
overview
diverse
applications,
risks,
stability
requirement,
cytocompatibility
opportunities
SeNPs.
Ultimately,
bridges
gap
knowledge
by
providing
updated
details
applications
Proceedings of the Institution of Mechanical Engineers Part N Journal of Nanomaterials Nanoengineering and Nanosystems,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
The
swift
applications
of
nanoparticles
(NPs)
in
different
fields
such
as
pharmaceuticals,
semiconductor,
and
decontamination
require
a
comprehensive
evaluation
their
impacts
on
the
health
human
beings.
This
critical
review
consolidates
current
knowledge
nanoparticle
toxicity
with
an
attempt
to
unravel
biochemical
physiological
processes
by
which
NPs
may
harm
health.
Exposure
routes
including
aspiration,
skin
permeation,
direct
consumption
are
involved
especially
assessed
terms
biodistribution
biokinetics
living
organisms.
An
exploration
physico-chemical
characteristics
particle
size,
morphology,
surface
charge,
chemical
make-up
yields
fact
that
all
those
things
play
important
role
regulation
relation
other
include
cell
uptake,
generation
oxidative
stress,
inflammation.
New
data
define
linkages
between
NP
exposure
respiratory
cardiovascular
diseases,
Neurotoxicity,
potential
carcinogenicity.
further
relies
present
methodological
deficiencies
lack
harmonization
existing
assessments
for
chronic
risks
call
more
standardized
testing
protocols
elaborate
long-term
epidemiological
investigations.
goal
this
is
highlight
hazards
associated
nanoparticles.
In
addition,
authors
also
tried
contribute
regulatory
guidance
directions
design
safer
nanomaterials
will
help
protect
population
at
dawn
nanotechnologies.
