Biogenic selenium nanoparticles: a comprehensive update on the multifaceted application, stability, biocompatibility, risk, and opportunity

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract Biogenic selenium nanoparticles (SeNPs) have emerged as promising area of research due to their unique properties and potential multifaceted applications. The biosynthesis SeNPs through biological methods, such using microorganism, plant extracts, etc., offers a safe, eco-friendly, biocompatible approach, compared traditional chemical synthesis. Recent several studies demonstrated that application includes broad antibacterial, anticancer, antioxidant, antiviral, anti-inflammatory, antidiabetic, excellent wound healing activity. On the other hand, also shown in sensing inorganic toxic metals, electrochemistry, agro-industries, aqua-cultures, fabrication solar panels. Additionally, capability enhance efficacy antibiotics act effective agents against multidrug-resistant pathogens has addressing critical health challenges. Although, exhibit wide applicability, toxicity Se, particularly its various oxidative states, necessitates careful assessment environmental impacts associated with use. Therefore, understanding balance between beneficial risks is crucial for safe This review focuses exclusively on synthesized via eco-friendly process, excluding utilizing synthesis processes. Moreover, this aims offer an overview diverse applications, risks, stability requirement, cytocompatibility opportunities SeNPs. Ultimately, bridges gap knowledge by providing updated details applications

Language: Английский

---

Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate potential anti-inflammatory anti-oxidative properties. However, most lectin receptors bind free monosaccharide ligands with relatively low affinity Se species induce side effects beyond very narrow range dosage. This has contributed to poorly explored therapies for IBD that combine mannose target epithelial cells (IECs) normalization gut homeostasis. Herein, facile safe strategy ulcerative colitis (UC) treatment was developed using optimized, mannose-functionalized nanoparticles (M-SeNPs) encapsulated within colon-targeted hydrogel delivery system containing alginate (SA) chitosan (CS). biocompatible nanosystem efficiently taken up by IECs led increased expression Se-dependent glutathione peroxidases (GPXs), thereby modulating IECs' immune response. Using mouse model DSS-induced colitis, (CS/SA)-embedding M-SeNPs (C/S-MSe) were found mitigate oxidative stress inflammation through the inhibition NF-kB pathway in colon. stabilized mucosal ameliorated colitis-related symptoms, providing new approach IBD.

Language: Английский

---

Synergistic effects of dietary selenium nanoparticles and vitamin C improve growth performance, immune response, and antioxidant status of juvenile common carp (Cyprinus carpio)

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127530 - 127530

Published: Sept. 10, 2024

Language: Английский

---

The influence of bacterial selenium nanoparticles biosynthesized by Bacillus subtilus DA20 on blood constituents, growth performance, carcass traits, and gut microbiota of broiler chickens

Poultry Science, Journal Year: 2023, Volume and Issue: 102(9), P. 102848 - 102848

Published: June 10, 2023

Selenium is one of the necessary micronutrients needed for enhanced gut microbiota and oxidative stress poultry, so it improves their performance. In this study, Bacillus subtilus DA20 isolate that identified at gene level by PCR was employed to produce eco-friendly selenium nanoparticles (BSeNPs) investigate effects on growth performance, carcass characteristics, blood parameters, Indian River (IR) broiler chickens. The obtained were spherical with size 56 nm net negative charge -22.36 mV; BSeNPs surrounded active compounds, which besides tiny attributed antioxidant antibacterial activity. Forty hundred eighty unsexed IR broilers, 1-day old, reared 35 d. chicks weighed separately distributed into 3 treatment groups; each group contained 4 replicates (40 birds per replicate). Chicks in first, second, third, fourth groups fed control diets supplemented 0, 20, 40, 60 µg/kg BSeNPs, respectively; but fifth 300 bulk selenium. Dietary supplementation diet) significantly increased body weight decreased feed conversion ratio. Additionally, dietary (P = 0.046) lowered fat content 24% compared control; other hand, breast muscle 0.035) 19%. total bacterial count (TBC), yeast mold (TYMC), E. coli, Salmonella counts Se control. However, lactic acid bacteria (LAB) (60 μg/kg) when control, showing beneficial reducing pathogens enhancing bacteria, reflects

Language: Английский

---

Selenium-Fortified Kombucha–Pollen Beverage by In Situ Biosynthesized Selenium Nanoparticles with High Biocompatibility and Antioxidant Activity

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1711 - 1711

Published: Sept. 2, 2023

Biogenic selenium nanoparticles (SeNPs) have been shown to exhibit increased bioavailability. Fermentation of pollen by a symbiotic culture bacteria and yeasts (SCOBY/Kombucha) leads the release content enhances prebiotic probiotic effects Kombucha. The aim this study was fortify Kombucha beverage with SeNPs formed in situ fermentation pollen. Response Surface Methodology (RSM) used optimize biosynthesis pollen-fermented beverage. were characterized Transmission electron microscopy energy-dispersive X-ray spectroscopy (TEM-EDX), Fourier-transform infrared (FTIR), Dynamic light scattering (DLS), Zeta potential. enriched measuring total phenolic content, antioxidant activity, soluble silicon, saccharides, lactic acid, Se0. polyphenols identified liquid chromatography-mass spectrometry (LC-MS). bacterial (nano)cellulose scanning microscopy-energy dispersive (SEM-EDX), FTIR, X-Ray diffraction (XRD). We also assessed vitro biocompatibility terms gingival fibroblast viability proliferation, as well activity SeNPs. results highlight their biological performance regard.

Language: Английский

---

Layered Double Hydroxides as Next-Generation Adsorbents for the Removal of Selenium from Water

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8513 - 8513

Published: Sept. 21, 2024

This research paper provides a comprehensive overview of the use layered double hydroxides (LDH) in removal selenium species from contaminated water sources. Key studies on sorption mechanisms and impact competing ions are presented, effectiveness LDH is compared across different structures compositions. Scholarly sources extensively document application conventional for effective removal, with notable advancements achieved through innovative synthesis approaches. Comparative between synthesized various methods reveal potential tailored enhanced adsorption. The further explores influence anions efficacy, emphasizing sulfate removal. Additionally, investigations into calcined commercially available variants underscore industrial applications. Beyond LDH, delves iron-based intercalated thiomolybdate anions, rare earth hydroxides, exploring their separating species. role pH three-metal cation also discussed. study extends to nanocomposites, combining zero-valent iron, carbon-based materials, organic compounds, illustrating immobilization. presented findings offer valuable insights researchers practitioners environmental science, addressing growing demand efficient remediation strategies.

Language: Английский

---

The Developments of Surface-Functionalized Selenium Nanoparticles and Their Applications in Brain Diseases Therapy

Biomimetics, Journal Year: 2023, Volume and Issue: 8(2), P. 259 - 259

Published: June 15, 2023

Selenium (Se) and its organic inorganic compounds in dietary supplements have been found to possess excellent pharmacodynamics biological responses. However, Se bulk form generally exhibits low bioavailability high toxicity. To address these concerns, nanoscale selenium (SeNPs) with different forms, such as nanowires, nanorods, nanotubes, synthesized, which become increasingly popular biomedical applications owing their bioactivity, are widely used oxidative stress-induced cancers, diabetes, other diseases. pure SeNPs still encounter problems when applied disease therapy because of poor stability. The surface functionalization strategy has it sheds light overcome limitations further improve the activity SeNPs. This review summarizes synthesis methods strategies employed for preparation highlights treating brain

Language: Английский

---

Selenium nanoparticles stabilized with chitosan for fortifying dairy products

Agrarian science, Journal Year: 2024, Volume and Issue: 1(9), P. 130 - 135

Published: Oct. 12, 2024

Relevance . One solution to the problem of selenium deficiency is enrichment socially important food products, in particular dairy with bioavailable forms selenium. Such include nanoparticles. The aim work develop a product enriched nanoparticles stabilized chitosan. Methods According dynamic light scattering spectroscopy, sample chitosan has monomodal size distribution an average hydrodynamic particle radius 25 nm. Results Quantum chemical modeling by revealed that most energetically favorable interaction surface hydroxo group attached C3 glucosamine residue A study was conducted influence technological parameters on stability It found increasing exposure time leads increase In case pH, inverse relationship observed: particles largest are samples acidic environment (pH ˂ 5). As part chitosan, it can be used as source for products have neutral but subjected heat treatment at temperatures above 70 °C 5–15 minutes, pasteurized milk. milk fortified showed there were no significant changes titratable acidity, tension and pH milk, well casein micelles after fortification. value antioxidant activity increases 0.88% — from 6.50 7.38%.

Language: Английский

---

Nanomedicines for Dry Eye Syndrome: Targeting Oxidative Stress with Modern Nanomaterial Strategies

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3732 - 3732

Published: Aug. 7, 2024

Dry eye syndrome (DES) is a dynamic, chronic disease of the ocular surface and appendages caused by inflammation. The most common symptoms include redness, itching, blurred vision, resulting from dysfunction meibomian glands impaired tear-film production. Factors contributing to development DES environmental elements, such as UV radiation, internal hormonal imbalances. These factors increase oxidative stress, which exacerbates inflammation on accelerates DES. In recent years, incidence has risen, leading greater need develop effective treatments. Current treatments for dry are limited primarily focus alleviating individual symptoms, reducing surface. However, it crucial understand pathomechanism tailor treatment address underlying causes achieve best possible therapeutic outcomes. Therefore, in this review, we analyzed impact stress gain better understanding its examined recently developed nanosystems that allow drugs be delivered directly site.

Language: Английский

---

Biosynthesized Selenium-hydroxytyrosol nanoparticles attenuate hepatocellular carcinoma in rats

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Hepatocellular carcinoma (HCC) is a life-threatening disease with global impact, underscoring the urgent need for development of new therapeutic agents. This study evaluates effect selenium-hydroxytyrosol nanoparticles (Se-HTNPs) in rat model HCC induced by diethylnitrosamine (DEN). In vitro, Se-HTNPs treatment reduced viability Hep G2 cells dose-dependent manner, an IC₅₀ value 61.29 ± 1.12 µg/mL. The results confirmed antioxidant, anti-inflammatory, and anti-carcinogenic properties Se-HTNPs, demonstrating their effectiveness against DEN-induced HCC. effects were validated inhibiting serum ALT, AST, ALP enzyme activities reducing total bilirubin levels. Simultaneously, enhanced albumin protein Additionally, alleviated oxidative stress significantly lowering hepatic lipid peroxidation (MDA) levels markedly increasing antioxidant marker (GSH, SOD, TAC) compared to DEN-administered rats. also inflammatory markers (TNFα, IL-6, IL-1β), apoptotic (p53 caspase 3), VEGF Furthermore, DEN group, distinctly suppressed c-JNK mRNA NF-κB gene expression Moreover, Se-HTNP improved histological alterations DEN. conclusion, these findings suggest that mitigate rats through potent properties.

Language: Английский

---