Fully biodegradable hierarchically designed high-performance nanocellulose piezo-arrays
Science Advances,
Год журнала:
2025,
Номер
11(3)
Опубликована: Янв. 15, 2025
While
piezoelectric
sensing
and
energy-harvesting
devices
still
largely
rely
on
inorganic
components,
biocompatible
biodegradable
materials,
such
as
cellulose
nanocrystals,
might
constitute
optimal
sustainable
building
blocks
for
a
variety
of
applications
in
electronics
transient
implants.
To
this
aim,
however,
effective
methods
are
needed
to
position
nanocrystals
large
high-performance
architectures.
Here,
we
report
scalable
assemblies
multilayered
systems
with
exceptional
response,
various
application
scopes.
The
submicrometer
patterning
effective-flow
topography
multilayer
stacking
promote
performance.
Record
output
power
pressure
sensitivity
the
gentle
touch
range
obtained
flexible,
fully
stable
properties
demonstrated
compatibility
different
cell
lines
implanted
devices.
These
architectures
offer
new
design
principles
materials
realizing
an
innovative
class
practical
components
mechanical
energy
harvesting
biologically
relevant
wearables
Язык: Английский
Modeling and characterization of lenalidomide-loaded tripolyphosphate-crosslinked chitosan nanoparticles for anticancer drug delivery
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
260, С. 129360 - 129360
Опубликована: Янв. 11, 2024
Язык: Английский
Chitosan Nanoparticles for Intranasal Drug Delivery
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 746 - 746
Опубликована: Май 31, 2024
This
manuscript
explores
the
use
of
nanostructured
chitosan
for
intranasal
drug
delivery,
targeting
improved
therapeutic
outcomes
in
neurodegenerative
diseases,
psychiatric
care,
pain
management,
vaccination,
and
diabetes
treatment.
Chitosan
nanoparticles
are
shown
to
enhance
brain
improve
bioavailability,
minimize
systemic
side
effects
by
facilitating
transport
across
blood–brain
barrier.
Despite
substantial
advancements
targeted
delivery
vaccine
efficacy,
challenges
remain
scalability,
regulatory
approval,
transitioning
from
preclinical
studies
clinical
applications.
The
future
chitosan-based
nanomedicines
hinges
on
advancing
trials,
fostering
interdisciplinary
collaboration,
innovating
nanoparticle
design
overcome
these
hurdles
realize
their
potential.
Язык: Английский
Chitosan nanoparticles for nasal drug delivery
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106623 - 106623
Опубликована: Янв. 1, 2025
Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects
Ageing Research Reviews,
Год журнала:
2024,
Номер
98, С. 102318 - 102318
Опубликована: Май 4, 2024
Язык: Английский
Chitosan: Structural and Chemical Modification, Properties, and Application
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 554 - 554
Опубликована: Дек. 31, 2023
Chitosan
is
a
polymer
of
natural
origins
that
possesses
many
favourable
properties
[...]
Язык: Английский
Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation
Nano Letters,
Год журнала:
2024,
Номер
24(33), С. 10380 - 10387
Опубликована: Авг. 9, 2024
The
advancement
of
effective
nasal
mucoadhesive
delivery
faces
challenges
due
to
rapid
mucociliary
clearance
(MCC).
Conventional
studies
have
employed
materials,
mainly
forming
spherical
nanoparticles,
but
these
offer
limited
adhesion
the
mucosa.
This
study
hypothesizes
that
a
2D
nanoscale
structure
utilizing
adhesive
polyphenols
can
provide
superior
strategy
for
countering
MCC,
aligning
with
planar
mucosal
layers.
We
explore
use
tannic
acid
(TA),
polyphenolic
molecule
known
its
properties
and
ability
form
complexes
biomolecules.
Our
introduces
an
unprecedented
nanopatch,
assembled
through
interaction
TA
green
fluorescent
protein
(GFP),
cell-penetrating
peptide
(CPP).
nanopatch
demonstrates
robust
mucosa
significantly
enhances
immunoglobulin
A
secretions,
suggesting
potential
enhancing
vaccine
delivery.
promise
polyphenol-enabled
signifies
pivotal
shift
from
conventional
opening
new
pathways
strategies
respiratory
mucoadhesion.
Язык: Английский
Bile acid conjugated chitosan nanoparticles promote the proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma by regulating the PI3K/Akt/mTOR pathway
Carbohydrate Research,
Год журнала:
2024,
Номер
545, С. 109296 - 109296
Опубликована: Окт. 23, 2024
Язык: Английский
Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery
Shuai Hong,
Changxiu Lin,
Junsheng Hu
и другие.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(10), С. 5217 - 5237
Опубликована: Авг. 26, 2024
Nimodipine
is
the
primary
clinical
drug
used
to
treat
cerebral
vasospasm
following
subarachnoid
hemorrhage.
Currently,
tablets
have
low
bioavailability
when
taken
orally,
and
injections
contain
ethanol.
Therefore,
we
investigated
a
new
method
of
nimodipine
administration,
namely,
nasoencephalic
administration.
Nasal
administration
was
carried
out
by
attaching
cell-penetrating
peptide
octa-arginine
(R8)
liposomes
incorporating
it
into
temperature-sensitive
in
situ
gel.
The
prepared
gels
underwent
separate
evaluations
for
vitro
characterization.
In
release
exhibited
significant
slow-release
effect.
toad
maxillary
cilia
model,
RPMI
2650
cytotoxicity,
vivo
SD
rat
pathological
histotoxicity
experiments
showed
that
all
dosage
from
groups
had
no
toxicity
cilia,
cells,
tissues
organs,
continued
oscillate
up
694
±
10.15
min,
with
survival
rate
cells
being
above
85%.
A
transwell
nasal
mucosa
cell
model
an
isolated
porcine
were
established,
results
osmolality
R8-modified
liposomal
gel
mucosal
30.41
2.14
65.9
7.34
μg/mL,
respectively,
which
significantly
higher
than
NM-Solution
PEGylated
liposome
groups.
Animal
fluorescence
imaging
studies
revealed
displayed
increased
brain
intensity
compared
normal
Pharmacokinetic
after
transnasal
AUC
Язык: Английский