Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery DOI

Shuai Hong,

Changxiu Lin,

Junsheng Hu

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(10), P. 5217 - 5237

Published: Aug. 26, 2024

Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new method of nimodipine administration, namely, nasoencephalic administration. Nasal administration was carried out by attaching cell-penetrating peptide octa-arginine (R8) liposomes incorporating it into temperature-sensitive in situ gel. The prepared gels underwent separate evaluations for vitro characterization. In release exhibited significant slow-release effect. toad maxillary cilia model, RPMI 2650 cytotoxicity, vivo SD rat pathological histotoxicity experiments showed that all dosage from groups had no toxicity cilia, cells, tissues organs, continued oscillate up 694 ± 10.15 min, with survival rate cells being above 85%. A transwell nasal mucosa cell model an isolated porcine were established, results osmolality R8-modified liposomal gel mucosal 30.41 2.14 65.9 7.34 μg/mL, respectively, which significantly higher than NM-Solution PEGylated liposome groups. Animal fluorescence imaging studies revealed displayed increased brain intensity compared normal Pharmacokinetic after transnasal AUC

Language: Английский

Fully biodegradable hierarchically designed high-performance nanocellulose piezo-arrays DOI Creative Commons
Sujoy Kumar Ghosh,

Francesca Matino,

Fabio Lineu Favrin

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(3)

Published: Jan. 15, 2025

While piezoelectric sensing and energy-harvesting devices still largely rely on inorganic components, biocompatible biodegradable materials, such as cellulose nanocrystals, might constitute optimal sustainable building blocks for a variety of applications in electronics transient implants. To this aim, however, effective methods are needed to position nanocrystals large high-performance architectures. Here, we report scalable assemblies multilayered systems with exceptional response, various application scopes. The submicrometer patterning effective-flow topography multilayer stacking promote performance. Record output power pressure sensitivity the gentle touch range obtained flexible, fully stable properties demonstrated compatibility different cell lines implanted devices. These architectures offer new design principles materials realizing an innovative class practical components mechanical energy harvesting biologically relevant wearables

Language: Английский

Citations

4
Modeling and characterization of lenalidomide-loaded tripolyphosphate-crosslinked chitosan nanoparticles for anticancer drug delivery DOI

Afsaneh Moghaddam Jafari,

Ali Morsali, Mohammad Reza Bozorgmehr

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129360 - 129360

Published: Jan. 11, 2024

Language: Английский

Citations

10
Chitosan Nanoparticles for Intranasal Drug Delivery DOI Creative Commons
Hossein Omidian, Erma J. Gill, Sumana Dey Chowdhury

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 746 - 746

Published: May 31, 2024

This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain improve bioavailability, minimize systemic side effects by facilitating transport across blood–brain barrier. Despite substantial advancements targeted delivery vaccine efficacy, challenges remain scalability, regulatory approval, transitioning from preclinical studies clinical applications. The future chitosan-based nanomedicines hinges on advancing trials, fostering interdisciplinary collaboration, innovating nanoparticle design overcome these hurdles realize their potential.

Language: Английский

Citations

10
Chitosan nanoparticles for nasal drug delivery DOI Creative Commons

Salah Alghareeb,

Ifeoma Cynthia Ekenna, Kofi Asare‐Addo

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106623 - 106623

Published: Jan. 1, 2025

Citations

1
Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects DOI
Farhan Mazahir,

Md Imtiyaz Alam,

Awesh K. Yadav

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102318 - 102318

Published: May 4, 2024

Language: Английский

Citations

3
Chitosan: Structural and Chemical Modification, Properties, and Application DOI Open Access
Joanna Kluczka

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 554 - 554

Published: Dec. 31, 2023

Chitosan is a polymer of natural origins that possesses many favourable properties [...]

Language: Английский

Citations

5
Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation DOI
Jeong Pil Han,

Yu Ri Nam,

Hye Yoon Chung

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(33), P. 10380 - 10387

Published: Aug. 9, 2024

The advancement of effective nasal mucoadhesive delivery faces challenges due to rapid mucociliary clearance (MCC). Conventional studies have employed materials, mainly forming spherical nanoparticles, but these offer limited adhesion the mucosa. This study hypothesizes that a 2D nanoscale structure utilizing adhesive polyphenols can provide superior strategy for countering MCC, aligning with planar mucosal layers. We explore use tannic acid (TA), polyphenolic molecule known its properties and ability form complexes biomolecules. Our introduces an unprecedented nanopatch, assembled through interaction TA green fluorescent protein (GFP), cell-penetrating peptide (CPP). nanopatch demonstrates robust mucosa significantly enhances immunoglobulin A secretions, suggesting potential enhancing vaccine delivery. promise polyphenol-enabled signifies pivotal shift from conventional opening new pathways strategies respiratory mucoadhesion.

Language: Английский

Citations

1
Bile acid conjugated chitosan nanoparticles promote the proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma by regulating the PI3K/Akt/mTOR pathway DOI
Ziyu Jiang, Yi Xu,

Liu Yang

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 545, P. 109296 - 109296

Published: Oct. 23, 2024

Language: Английский

Citations

1
Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery DOI

Shuai Hong,

Changxiu Lin,

Junsheng Hu

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(10), P. 5217 - 5237

Published: Aug. 26, 2024

Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new method of nimodipine administration, namely, nasoencephalic administration. Nasal administration was carried out by attaching cell-penetrating peptide octa-arginine (R8) liposomes incorporating it into temperature-sensitive in situ gel. The prepared gels underwent separate evaluations for vitro characterization. In release exhibited significant slow-release effect. toad maxillary cilia model, RPMI 2650 cytotoxicity, vivo SD rat pathological histotoxicity experiments showed that all dosage from groups had no toxicity cilia, cells, tissues organs, continued oscillate up 694 ± 10.15 min, with survival rate cells being above 85%. A transwell nasal mucosa cell model an isolated porcine were established, results osmolality R8-modified liposomal gel mucosal 30.41 2.14 65.9 7.34 μg/mL, respectively, which significantly higher than NM-Solution PEGylated liposome groups. Animal fluorescence imaging studies revealed displayed increased brain intensity compared normal Pharmacokinetic after transnasal AUC

Language: Английский

Citations

0