Animal nutrition,
Год журнала:
2023,
Номер
15, С. 225 - 232
Опубликована: Сен. 9, 2023
Sustained
dysfunction
of
the
intestinal
barrier
caused
by
early
weaning
is
a
major
factor
that
induces
postweaning
diarrhea
in
weaned
piglets.
In
both
healthy
and
diseased
states,
regulated
goblet
cells.
Alterations
characteristics
cells
are
linked
to
inflammatory
conditions
during
pathogenic
infections.
this
review,
we
summarize
current
understanding
mechanisms
unfolded
protein
response
(UPR)
anterior
gradient
2
(AGR2)
maintaining
function
how
modifications
these
systems
affect
mucus
cell
dysregulation.
We
highlight
novel
mechanism
underlying
UPR-AGR2
pathway,
which
affects
differentiation
maturation
synthesis
secretion
mucin
regulating
epidermal
growth
receptor
2.
This
study
provides
theoretical
basis
new
insights
into
regulation
health
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
17(2), С. 105563 - 105563
Опубликована: Дек. 14, 2023
Bisphenol
A(BPA)
is
a
non-persistent,
anthropic
compound
and
continues
to
be
ubiquitous
in
the
environment.
Since
BPA
estrogenic
nature,
its
exposure
induces
adverse
cellular
responses
associated
with
oxidative
stress
inflammation.
Hesperetin,
major
flavonoid
present
lemons
sweet
oranges
exhibits
broad
spectrum
of
pharmacological
effects
attributed
potent
anti-inflammatory
antioxidant
status.
The
current
study
reports
'green'
synthesis
nano
hesperetin
(NHsp)
followed
by
characterization
that
included;
Fourier
Transform
Infrared
spectroscopy
(FTIR),
X-Ray
Diffraction
(XRD),
Transmission
Electron
Microscopy
(TEM),
Scanning
(SEM)
Dynamic
Light
Scattering
(DLS).
In
accordance
findings,
mean
size
synthesized
nanoparticles
was
139.9
nm
PDI
0.362.
morphotype
primarily
spherical
rod
shaped.
This
comparative
assessment
ameliorative
efficacy
bulk
against
BPA-induced
hepatotoxicity
rat.
findings
showed
post-exposure
250mg/kg
for
21
days
significantly
enhanced
pro-inflammatory
cytokines
(IL-6,
IL-8,
IL-1β,
TNF-α),
serum
whereas
treatment
both
(Hst)
(NHst)
reduced
levels.
paralleled
modulatory
on
histology
liver
kidney
which
were
reversed
treatment.
Taken
together,
more
efficacious
alleviating
toxicity.
Thus,
formulation
could
potentially
promising
nutraceuticals
medicine
industry.
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Май 10, 2024
Microencapsulated
essential
oils
(MEO)have
been
used
as
antibiotic
alternatives
that
can
be
applied
to
alleviate
diarrhea
in
weaning
piglet.
We
examined
a
large
group
of
weaned
piglets
and
incorporated
oil
containing
thymol
(2%),
carvacrol
(5%)
cinnamaldehyde
(3%)
the
feed
on
an
intensive
production
farm.
The
were
divided
into
four
groups;
Control
(no
additions)
chlortetracycline
(Chl),
(EO)
microencapsulated
(MEO)
fed
ad
libitum
over
28-day
trial
period.
found
MEO
significantly
reduced
incidence
was
also
accompanied
by
increased
average
daily
weight
gains
from
days
14–28
(
p
<
0.05).
enhanced
antioxidant
capacity
serum
total
(T-AOC)
glutathione
peroxidase
(GSH-px)
levels
expression
genes
related
ileal
inflammation
IL-6
,
TNF-α
TGF-β1
)
0.05)
sIgA
antibody
levels.
influenced
composition
intestinal
microbiome
Bacteroidota
thus
altered
Firmicutes/Bacteroidota
ratio.
However,
none
treatments
produced
significant
changes
most
common
tetracycline
resistance
>
Metagenomic
analysis
indicated
impacted
DNA
expression,
virulence
factors,
activity
antimicrobial
activity.
Metabolomic
content
tyrosine
metabolism
primary
bile
acid
biosynthesis
suggesting
improved
health
nutrient
absorption.
This
study
paves
way
for
further
research
development
optimization
MEO-based
interventions
aimed
at
improving
piglet
performance
while
providing
reference
reducing
reliance
antibiotics
animal
agriculture.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 555 - 555
Опубликована: Дек. 31, 2023
Humans
and
animals
may
be
exposed
on
a
continuous
daily
basis
to
mixture
of
environmental
contaminants
that
act
several
organ
systems
through
differing
mechanisms
[...].
Animal nutrition,
Год журнала:
2023,
Номер
15, С. 225 - 232
Опубликована: Сен. 9, 2023
Sustained
dysfunction
of
the
intestinal
barrier
caused
by
early
weaning
is
a
major
factor
that
induces
postweaning
diarrhea
in
weaned
piglets.
In
both
healthy
and
diseased
states,
regulated
goblet
cells.
Alterations
characteristics
cells
are
linked
to
inflammatory
conditions
during
pathogenic
infections.
this
review,
we
summarize
current
understanding
mechanisms
unfolded
protein
response
(UPR)
anterior
gradient
2
(AGR2)
maintaining
function
how
modifications
these
systems
affect
mucus
cell
dysregulation.
We
highlight
novel
mechanism
underlying
UPR-AGR2
pathway,
which
affects
differentiation
maturation
synthesis
secretion
mucin
regulating
epidermal
growth
receptor
2.
This
study
provides
theoretical
basis
new
insights
into
regulation
health
