BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 5, 2024
Abstract
Background
Diabetes,
a
known
syndrome
marked
by
hyperglycemia
and
glucose
intolerance,
is
increasing
at
an
alarming
rate
worldwide.
Over
half
billion
people
worldwide
have
DM,
most
live
in
low-
middle-income
countries.
Poor
glycemic
control
public
health
concern
type
2
diabetes
mellitus.
Glycemic
identifying
factors
associated
with
poor
can
help
healthcare
providers
design
programs
that
improve
the
quality
of
services
provided
to
patients.
Objectives
This
study
was
designed
assess
level
patients
Jimma
Medical
Center,
Southwest
Ethiopia.
Methods
institution-based
prospective
observational
conducted
among
420
Center’s
diabetic
clinics.
A
pretested
structured
interviewer-administered
questionnaire
used
collect
data,
checklist
patient
documents.
The
data
were
analyzed
using
SPSS
version
26.
variables
linked
investigated
binary
logistic
regression.
Variables
p
values
less
than
0.05
considered
statistically
significant.
Results
Six-month
follow-ups
diabetes,
whom
220
(52.38%)
women.
median
age
participants
54(IQR
=
40–60
years
old).
proportion
respondents
uncontrolled
fasting
blood
58.1%.
Sex
(AOR
2.576,
95%
CI
[2.80-11.479],
P
0.001),
age(≥
60)
2.024,
[1.794–4.646],
0.002),
duration
>
10
3.036,
[2.616–8.306],
0.003),
mellitus
on
insulin
+
oral
antidiabetic
(OADs)
2.08,
[298-3.918],
0.004),
obesity
2.18,
[(1.218–4.218)],
complications
3.193,
[2.324–6.05],
0.002)
self-care
practices
3.034,
[5.821–7.02],
0.005)
found
be
significantly
control.
Conclusion
At
prevalence
high.
Based
these
findings,
teaching
counseling
should
focus
improving
activities,
weight
reduction,
achieve
good
Clinical
trial
number
Not
applicable.
Nutrients,
Год журнала:
2024,
Номер
16(13), С. 2156 - 2156
Опубликована: Июль 6, 2024
Lipids
are
primarily
transported
in
the
bloodstream
by
lipoproteins,
which
macromolecules
of
lipids
and
conjugated
proteins
also
known
as
apolipoproteins.
The
processes
lipoprotein
assembly,
secretion,
transportation,
modification,
clearance
crucial
components
maintaining
a
healthy
lipid
metabolism.
Disruption
any
these
steps
results
pathophysiological
abnormalities
such
dyslipidemia,
obesity,
insulin
resistance,
inflammation,
atherosclerosis,
peripheral
artery
disease,
cardiovascular
diseases.
By
studying
genetic
mutations,
researchers
can
gain
valuable
insights
into
underlying
mechanisms
that
govern
relationship
between
protein
structure
its
physiological
role.
These
including
HDL,
LDL,
lipoprotein(a),
VLDL,
mainly
serve
purpose
transporting
tissues
organs.
However,
studies
have
provided
evidence
apo(a)
possesses
protective
properties
against
pathogens.
In
future,
field
study
will
be
significantly
influenced
integration
recombinant
DNA
technology
human
site-specific
mutagenesis
for
treating
hereditary
disorders.
Several
medications
available
treatment
dyslipoproteinemia.
include
statins,
fibrates,
ezetimibe,
niacin,
PCSK9
inhibitors,
evinacumab,
DPP
4
glucagon-like
peptide-1
receptor
agonists
GLP1RAs,
GLP-1,
GIP
dual
agonists,
addition
to
SGLT2
inhibitors.
This
current
review
article
exhibits,
first
time,
comprehensive
reflection
body
publications
concerning
impact
lipoproteins
on
metabolic
well-being
across
various
pathological
states.
Expert Opinion on Pharmacotherapy,
Год журнала:
2024,
Номер
25(3), С. 223 - 232
Опубликована: Фев. 11, 2024
Introduction
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
the
most
common
hepatic
affecting
almost
30%
of
world
population.
Approximately
25%
people
with
NAFLD
develop
nonalcoholic
steatohepatitis
(NASH),
fulminant
version
disease.
Diabetes
mellitus
present
in
22.5%
and
44.60%
individuals
NASH.
This
review
was
undertaken
to
examine
current
contribution
glucagon-like
peptide
1
(GLP-1)
receptor
agonists
pharmacotherapy
diabetic
steatohepatitis.
Biotechnology Progress,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Abstract
Type
2
diabetes
mellitus
(T2DM)
and
obesity
are
critical
global
health
issues
with
rising
incidence
rates.
Glucagon‐like
peptide‐1
(GLP‐1)
analogues
have
emerged
as
effective
treatments
due
to
their
ability
regulate
blood
glucose
levels
gastric
emptying
through
central
nervous
signals
involving
hypothalamic
receptors,
such
leptin.
To
address
the
short
plasma
half‐life
of
native
GLP‐1,
a
C‐16
fatty
acid
was
conjugated
lysine
in
GLP‐1
analogue
sequence
enhance
its
longevity.
This
study
focuses
on
engineering
high‐throughput
clone
evaluation
novel
improved
bio‐efficacy
production
yields.
Five
plasmid
models
were
created
using
different
N‐terminal
fusion
partners
assessed
for
hydrophobicity,
instability
index,
isoelectric
point.
Three
optimal
selected
based
high‐valued
solubility,
partial
solubility.
These
plasmids
constructed
pET24a
vector,
incorporating
tags
via
recombinant
DNA
technology
transformed
into
E.
coli
BL21
DE3
hosts.
The
proteins
purified
enzyme
digestion
chromatography,
resulting
high‐yield
peptide.
peptide
in‐house
developed
compound
n‐Palmitoyl
glutamic
(n‐PGA)
C18
column
achieving
final
product
yield
170–190
mg
per
liter
fermentation
culture.
Biological
activity
confirmed
by
cyclic
adenosine
monophosphate
(cAMP)
generation
3
T3
cell
differentiation
assays,
showing
1.5‐fold
increase
mRNA
gene
expression
having
n‐terminal
hydrophobic
amino
acids,
thioredoxin‐modified
tag,
enterokinase
cleavage
site,
indicating
high
purity
biological
potency
analogue.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1773 - 1773
Опубликована: Фев. 19, 2025
The
human
microbiota,
a
complex
ecosystem
of
microorganisms,
plays
pivotal
role
in
regulating
host
immunity
and
metabolism.
This
review
investigates
the
interplay
between
microbiota
inflammatory
markers,
emphasizing
their
impact
on
metabolic
autoimmune
disorders.
Key
biomarkers,
such
as
C-reactive
protein
(CRP),
interleukin-6
(IL-6),
lipopolysaccharides
(LPS),
zonulin
(ZO-1),
netrin-1
(Ntn1),
are
discussed
context
intestinal
barrier
integrity
chronic
inflammation.
Dysbiosis,
characterized
by
alterations
microbial
composition
function,
directly
modulates
levels
activity
these
exacerbating
responses
compromising
epithelial
barriers.
disruption
is
further
correlated
with
increased
permeability
inflammation,
serving
precursor
to
conditions
like
type
2
diabetes
(T2D),
obesity,
non-alcoholic
fatty
liver
disease.
Additionally,
this
examines
therapeutic
strategies,
including
probiotics
prebiotics,
designed
restore
balance,
mitigate
enhance
homeostasis.
Emerging
evidence
positions
microbiota-targeted
interventions
critical
components
advancement
precision
medicine,
offering
promising
avenues
for
diagnosing
treating
Abstract
This
study
reported
the
discovery
of
sulfonate
ester
analogues
2‐(2‐benzylidenehydrazono)‐4‐oxothiazolidine‐5‐acetic
acid
as
α‐glucosidase
inhibitors.
Sulfonate
acids
were
synthesized,
and
characterized.
The
synthesized
compounds
evaluated
for
in
vitro
inhibition
anti‐oxidant
activities.
All
derivatives
exhibited
significant
inhibitory
activities
against
enzyme
compared
to
acarbose.
Compound
7d
emerged
be
most
potent
with
IC
50
value
29.39
µM.
Safety
profile
was
established
by
MTT
assay
normal
HEK
cells.
Further,
vivo
disaccharide
loading
test
validated
higher
efficacy
over
acarbose
at
a
dose
20
mg/kg
body
weight.
In
silico
studies
involving
molecular
docking,
binding
free
energy
calculations
ADME
predictions
further
results.
