Therapeutic Efficacy of Helianthemum lippii Extract and Silver Nanoparticles Synthesized from the Extract against Cadmium-Induced Renal Nephrotoxicity in Wistar Rats

Pharmaceuticals, Год журнала: 2024, Номер 17(8), С. 982 - 982

Опубликована: Июль 25, 2024

This study explored the therapeutic efficacy of

Язык: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091

Опубликована: Ноя. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Язык: Английский

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Development and Applications of Bambusa stenostachya Leaf Extract in Personal Care Products

Processes, Год журнала: 2025, Номер 13(1), С. 233 - 233

Опубликована: Янв. 15, 2025

Concerns about the safety of traditional preservatives in personal care products are driving interest toward self-preserving alternatives. This study explores potential B. stenostachya leaf extracts, a natural and biodegradable material, for use cosmetics. stenostachya, fast-growing bamboo species native to Taiwan, is rich bioactive compounds, including flavonoids with antimicrobial properties. Leaves were obtained from Industrial Technology Research Institute (ITRI) Tainan, extracted using ultrasonic Soxhlet methods water, 50% ethanol, 95% ethanol. The highest yield was achieved ethanol at 100 °C. Cytotoxicity evaluated NIH/3T3 mouse fibroblast cell line, no toxicity observed dilutions between 1/3200 1/400, indicating extract’s cosmetic use. Antimicrobial activity tested accordance ISO 11930:2019 standards. extract effectively inhibited Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus pathogens, meeting preservative efficacy Standards A B long-term microbial control. Bamboo sustainable resource lower environmental impacts, its show promising biodegradability reduced footprints. research indicates that offers alternative chemical preservatives, promoting both sustainability public health, expanded formulations.

Язык: Английский

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From Waste to Value: Optimization of Ultrasound-Assisted Extraction of Anthocyanins and Flavonols from Pistacia lentiscus L. Oilcakes

Molecules, Год журнала: 2025, Номер 30(2), С. 237 - 237

Опубликована: Янв. 9, 2025

Pistacia lentiscus L., commonly known as the mastic tree or lentisk, is a woody Mediterranean plant revered for its ecological relevance well extensive ethnobotanical heritage. Historically, fruits and resin of P. have been widely utilized in traditional medicine, underscoring important role local healing practices. Given these properties, this study explored an innovative approach to efficiently extract anthocyanins flavonols from oilcakes utilizing ultrasound-assisted extraction (UAE) alternative conventional solvent extraction. Liquid chromatography-mass spectrometry (LC-MS) high-performance liquid chromatography with diode-array detection (HPLC-DAD) were used identify quantify flavonols, revealing successful eight distinct twenty flavonols. A Fractional Factorial Design (FFD) followed by Box-Behnken design (BBD) applied optimize yield The optimal conditions found be time 15 min 70% ethanol liquid-to-solid ratio 0.012 L g-1, which resulted maximum 19.78 mg g-1 dry Total Flavonol Content over 25.4 Anthocyanin Content. By elucidating extracting flavonol glycosides, opens promising avenues oilcake by-products, supporting sustainable practices, advancing valorization bio-resources health-promoting applications.

Язык: Английский

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Cadmium-Induced Kidney Apoptosis Based on the IRE1α-XBP1 Signaling Pathway and the Protective Effect of Quercetin

Toxics, Год журнала: 2025, Номер 13(2), С. 129 - 129

Опубликована: Фев. 10, 2025

Cadmium (Cd) is an important environmental pollutant that can enter the body and inflict kidney damage. Quercetin (Que) a natural flavonoid compound alleviate damage in Cd-treated rats, but specific mechanism unclear. Herein, 24 male Sprague-Dawley rats were divided into four groups, namely control, Cd, Cd + Que, Que groups. Four weeks later, anesthetized with ether euthanized; then, their blood was collected kidneys removed. Renal function markers measured. Kidney tissue structure observed by HE staining, cell apoptosis detected TUNEL method, mRNA protein expression levels IRE1α-XBP1 signaling pathway analyzed RT-PCR Western blotting. Results showed treatment group exhibited decreased renal dysfunction pathologic injury. Cd-induced significantly increased (p < 0.01) related to pathway. Compared group, dysfunction. Conversely, decreased, of IRE1α XBP1 0.01). inflicted Therefore, restore caused through inhibition

Язык: Английский

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New Insights in Natural Bioactive Compounds for Periodontal Disease: Advanced Molecular Mechanisms and Therapeutic Potential

Molecules, Год журнала: 2025, Номер 30(4), С. 807 - 807

Опубликована: Фев. 10, 2025

Periodontal disease is a chronic inflammatory condition that destroys the tooth-supporting structures due to host's immune response microbial biofilms. Traditional periodontal treatments, such as scaling and root planing, pharmacological interventions, surgical procedures, have significant limitations, including difficulty accessing deep pockets, biofilm recolonization, development of antibiotic resistance. In light these challenges, natural bioactive compounds derived from plants, herbs, other sources offer promising alternative their anti-inflammatory, antioxidant, antimicrobial, tissue-regenerative properties. This review focuses on molecular mechanisms through which compounds, curcumin, resveratrol, epigallocatechin gallate (EGCG), baicalin, carvacrol, berberine, essential oils, Gum Arabic, exert therapeutic effects in disease. Bioactive inhibit critical pathways like NF-κB, JAK/STAT, MAPK while activating protective Nrf2/ARE, reducing cytokine production oxidative stress. They also activity matrix metalloproteinases (MMPs), preventing tissue degradation promoting healing. addition, demonstrated potential disrupt bacterial biofilms by interfering with quorum sensing, targeting cell membranes, enhancing efficacy.Bioactive modulate system shifting balance pro-inflammatory anti-inflammatory responses efferocytosis, helps resolve inflammation supports regeneration. However, despite challenges related poor bioavailability, stability oral cavity, absence large-scale clinical trials need be addressed. Future strategies should prioritize advanced delivery systems nanoparticles hydrogels enhance bioavailability sustain release, alongside long-term studies assess human populations. Furthermore, combining traditional treatments could provide synergistic benefits managing aims explore disease, emphasizing action offering insights into integration conventional therapies for more comprehensive approach health.

Язык: Английский

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Phytomedical Properties of Carica papaya for Boosting Human Immunity Against Viral Infections

Viruses, Год журнала: 2025, Номер 17(2), С. 271 - 271

Опубликована: Фев. 16, 2025

Carica papaya, a tropical fruit-bearing plant, has attracted significant attention for its diverse phytomedical properties and ability to regulate both innate adaptive immunity, making it promising natural therapeutic agent. C. papaya is rich in bioactive compounds that play multifaceted role immunomodulation. These constituents have demonstrated efficacy not only against the dengue virus but also other viral infections, including COVID-19 (Corona Virus Disease 2019), Human Immunodeficiency (HIV), Zika virus, others. The antiviral effects of are achieved through enhance host mitigate inflammation, reduce oxidative stress, inhibit replication, modulate immune responses. mechanisms highlight potential as candidate therapies, paving way further exploration pharmacological applications promoting eco-friendly, accessible healthcare solutions combating diseases. This review highlights extracts inhibiting replication modulating responses, emphasizing need studies clinical trials validate their medically viruses causing human

Язык: Английский

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Preventing Oral Dual Biofilm Development with Innovative Bioactive Varnishes

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(2), С. 70 - 70

Опубликована: Фев. 18, 2025

This study introduces innovative varnishes incorporating natural bioactive compounds to inhibit the formation of oral dual biofilms, a critical contributor dental caries and other diseases. The purpose this was evaluate effectiveness containing tt-farnesol, quercetin, theobromine in inhibiting mixed Streptococcus mutans Candida albicans biofilms. Mixed biofilms UA159 SC5314 were grown 96-well plates specialized culture medium. Approximately 0.2 mL experimental with A-1.5% or B-4.5% concentrations separately added wells using disposable applicator, vehicle varnish (lacking bioactives) serving as control. Biofilms incubated at 37 °C 5% CO2 for 24 h. Microbial viability determined terms colony-forming units per milliliter (CFU/mL), biofilm morphology evaluated qualitatively via scanning electron microscopy (SEM). Statistical analyses performed ANOVA/Tukey tests significance level. Varnishes A B achieved significant reductions microbial populations within (p < 0.05) compared control (C). SEM imaging revealed marked structural disruptions validating quantitative results. Higher demonstrated enhanced inhibitory effects. Bioactive enriched theobromine, tt-farnesol represent novel effective strategy development, offering promising advancement preventive dentistry.

Язык: Английский

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Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols

Molecules, Год журнала: 2025, Номер 30(6), С. 1211 - 1211

Опубликована: Март 8, 2025

Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.

Язык: Английский

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Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 690 - 690

Опубликована: Май 27, 2024

(1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular cancer, and diabetes, highlighting pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop characterise two novel formulations, F3 F4, as therapeutic interventions oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation filling powders capsules, capsule content evaluation, activity assessment formulations were assessed. These comprise combination well-established antioxidants like quercetin, biotin, coenzyme Q10, resveratrol. Through comprehensive testing, formulations' efficacy, stability, potential synergistic interactions evaluated. (4) Conclusions: findings underscore promising these disorders highlight significance mitigating their progression.

Язык: Английский

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