Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2229 - 2229
Опубликована: Сен. 30, 2024
Liver
fibrosis
is
the
pathological
deposition
of
extracellular
matrix
rich
in
fibrillar
collagen
within
hepatocytes
response
to
chronic
liver
injury
due
various
causes.
As
condition
advances,
it
can
progress
cirrhosis,
late
stages
which
are
irreversible.
Multiple
pathophysiological
mechanisms
and
cell
types
responsible
for
progression
cirrhosis.
Hepatic
stellate
cells
myofibroblast
activation
represent
a
key
event
fibrosis.
Capillarization
sinusoidal
endothelial
further
contributes
an
increase
portal
pressure.
Macrophages
neutrophils
produce
inflammatory
cytokines
participate
activating
hepatic
cells.
Although
initially
believed
be
irreversible,
early
now
found
reversible.
Furthermore,
advances
noninvasive
imaging
serum
studies
have
changed
improved
how
cirrhosis
evaluated
monitored.
there
currently
no
specific
approved
therapies
reverse
fibrosis,
management
underlying
diseases
has
been
halt
progression,
extent,
even
preventing
cirrhosis-related
complications.
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Авг. 1, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
highly
heterogeneous
malignancy
with
high
incidence,
recurrence,
and
metastasis
rates.
The
emergence
of
immunotherapy
has
improved
the
treatment
advanced
HCC,
but
problems
such
as
drug
resistance
immune-related
adverse
events
still
exist
in
clinical
practice.
immunosuppressive
tumor
microenvironment
(TME)
HCC
restricts
efficacy
essential
for
progression
metastasis.
Therefore,
it
necessary
to
elucidate
mechanisms
behind
TME
develop
apply
immunotherapy.
This
review
systematically
summarizes
pathogenesis
formation
TME,
by
which
accelerates
We
also
status
further
discuss
existing
challenges
potential
therapeutic
strategies
targeting
TME.
hope
inspire
optimizing
innovating
immunotherapeutic
comprehensively
understanding
structure
function
HCC.
The Egyptian Journal of Internal Medicine,
Год журнала:
2024,
Номер
36(1)
Опубликована: Фев. 12, 2024
Abstract
Background
Liver
fibrosis
results
from
chronic
liver
injury
and
is
characterized
by
excessive
deposition
of
extracellular
matrix
proteins
including
collagen.
It
can
progress
to
cirrhosis
failure.
Main
body
the
abstract
Multiple
cellular
signaling
pathways
drive
hepatic
stellate
cell
activation
fibrogenesis.
Advances
in
biomarkers,
imaging
modalities,
omics
platforms
enable
noninvasive
diagnosis
staging
fibrosis.
Emerging
antifibrotic
approaches
include
medications
like
pirfenidone,
obeticholic
acid,
monoclonal
antibodies
targeting
pro-fibrotic
mediators.
Cell
therapies
using
mesenchymal
stem
cells
demonstrate
potential
through
paracrine
immunosuppression.
Tissue-engineered
grafts
biomaterial
carriers
for
localized
drug
delivery
are
promising
technologies.
Microfluidic
liver-on-a-chip
with
patient-derived
provide
unprecedented
models
study
human
test
candidates.
Short
conclusion
Significant
has
elucidated
mechanisms
underlying
fibrogenesis
uncovered
novel
therapeutic
targets.
Ongoing
challenges
translating
preclinical
findings,
improving
efficacy,
enabling
personalized
precision
medicine
approaches.
Further
research
into
combinatorial
therapies,
tissue
engineering
technologies
will
advance
treatment
all
causes.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Archives of Gastroenterology Research,
Год журнала:
2023,
Номер
4(1), С. 14 - 23
Опубликована: Ноя. 14, 2023
Liver
fibrosis
resulting
from
chronic
liver
injury
can
progress
to
cirrhosis
and
failure.
Current
treatments
are
limited,
creating
an
urgent
need
for
novel
antifibrotic
therapies.
Multiple
emerging
approaches
have
shown
preclinical
promise
in
inhibiting
fibrogenesis
or
stimulating
regeneration,
including
artificial
support,
stem
cell
therapy,
cell/gene
nanomedicines,
immunotherapy,
herbal
medicines.
Artificial
support
provides
detoxification
but
has
inconsistent
transplant
bridging
benefits.
Stem
transplantation
demonstrates
paracrine
effects
differentiation
potential.
Cell
therapy
with
hepatocytes
modulatory
immune
cells,
as
well
genetic
engineering
approaches,
aims
replace
damaged
cells
suppress
inflammation.
Nanoparticles
enable
targeted
delivery
of
drugs
genes.
Immunotherapy
using
checkpoint
inhibitors,
vaccines,
engineered
attenuate
fibrogenesis-related
Some
traditional
Chinese
formulas
compounds
exhibit
antifibrotic,
anti-inflammatory,
regenerative
mechanisms.
Despite
encouraging
data,
most
therapies
yet
achieve
clinical
translation,
limited
by
challenges
safety,
delivery,
efficacy.
Combination
treatment
regimens
may
provide
maximal
therapeutic
impact.
Ongoing
optimization
rigorous
evaluation
needed
develop
effective
new
patients
disease.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
Journal of Pharmaceutical Analysis,
Год журнала:
2023,
Номер
14(5), С. 100902 - 100902
Опубликована: Ноя. 29, 2023
Liver
fibrosis
is
primarily
driven
by
the
activation
of
hepatic
stellate
cells
(HSCs),
a
process
associated
with
ferroptosis.
Ginsenoside
Rb1
(GRb1),
major
active
component
extracted
from
Panax
ginseng,
inhibits
HSC
activation.
However,
potential
role
GRb1
in
mediating
ferroptosis
remains
unclear.
This
study
examined
effect
on
liver
both
vivo
and
vitro,
using
CCl4-induced
mouse
model
primary
HSCs,
LX-2
cells.
The
findings
revealed
that
effectively
inactivated
HSCs
reducing
alpha-smooth
muscle
actin
Type
I
collagen
levels.
Moreover,
significantly
alleviated
vivo.
From
mechanistic
standpoint,
pathway
appeared
to
be
central
antifibrotic
effects
GRb1.
Specifically,
promoted
characterized
increased
glutathione
depletion,
malondialdehyde
production,
iron
overload,
accumulation
reactive
oxygen
species.
Intriguingly,
Beclin
1
(BECN1)
levels
decreased
System
Xc-key
subunit
SLC7A11.
Further
experiments
showed
BECN1
silencing
inhibited
GRb1-induced
mitigated
reduction
SLC7A11
caused
could
directly
interact
SLC7A11,
initiating
In
conclusion,
suppression
counteracted
inactivation
vitro.
Overall,
this
highlights
novel
inducing
promoting
inactivation,
at
least
partly
through
its
modulation
