Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Frontiers in Chemistry, Год журнала: 2025, Номер 12

Опубликована: Янв. 15, 2025

Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections resulting in alarmingly increasing rates of morbidity mortality. Plant derived compounds hold numerous antimicrobial properties, them very capable source counteract microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, insecticidal properties. It also used historically for its pain relief especially tooth ache. Clove nanoparticle synthesis is promising method combining therapeutics with metals at nanoscale. Such nanostructured systems combination the heterocyclic antibiotic clarithromycin could potentiate action plant extracts, decrease drug side effects improve activity. In this study, clove (C) was successfully synthesize silver nanoparticles (AgNP) create AgNPC AgNPCA (A = clarithromycin). The two underwent different analytical methods consisting SEM, EDS, DLS, UV-vis, FTIR XRD. These were against variety 10 pathogens exhibited good intermediate antibacterial resulted better properties smaller size. This study demonstrates potential mediated AgNP without clarithromycin.

Язык: Английский

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Impacts of Bacillus probiotics on productive performance and egg quality criteria in laying Japanese quails

The Journal of Applied Poultry Research, Год журнала: 2024, Номер 33(3), С. 100445 - 100445

Опубликована: Май 22, 2024

The present study aimed to determine the effects of adding Bacillus megaterium and amyloliquefaciens laying quail diets on performance, egg quality, internal organ weights. We used 96 Japanese (Coturnix coturnix Japonica) at 12 weeks age. birds were divided into three treatment groups (32 quails per group), each eight replicates (four replicate). research was carried out in periods 28 days each. diets; 1st group served as a control group, receiving only basal diet. 2nd 3rd experimental received 0.1% (1×109 CFU/g) B. an addition diet, respectively. Adding did not influence performance parameters statistically. Also, significantly (p<0.05) impacted albumen index, Haugh unit, yolk compared group. In contrast, applied species affect other quality parameter values. body weight, heart liver gizzard small intestine length, caecum length among slaughter examined. CFU/g), can be without causing significant difference characteristics, visceral weights

Язык: Английский

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Piperine, a phytochemical prevents the biofilm city of methicillin-resistant Staphylococcus aureus: A biochemical approach to understand the underlying mechanism

Microbial Pathogenesis, Год журнала: 2024, Номер 189, С. 106601 - 106601

Опубликована: Фев. 27, 2024

Язык: Английский

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Antifungal activity, synergistic effect and mode of action of Caraway (Carum carvi L.) essential oil and carvone against Aspergillus fumigatus

South African Journal of Botany, Год журнала: 2024, Номер 168, С. 588 - 594

Опубликована: Апрель 12, 2024

Язык: Английский

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Thymol, a Monoterpenoid within Polymeric Iodophor Formulations and Their Antimicrobial Activities

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4949 - 4949

Опубликована: Май 1, 2024

Antimicrobial resistance (AMR) poses an emanating threat to humanity’s future. The effectiveness of commonly used antibiotics against microbial infections is declining at alarming rate. As a result, morbidity and mortality rates are soaring, particularly among immunocompromised populations. Exploring alternative solutions, such as medicinal plants iodine, shows promise in combating resistant pathogens. Such antimicrobials could effectively inhibit proliferation through synergistic combinations. In our study, we prepared formulation consisting Aloe barbadensis Miller (AV), Thymol, iodine (I2), polyvinylpyrrolidone (PVP). Various analytical methods including SEM/EDS, UV-vis, Raman, FTIR, XRD were carried out verify the purity, composition, morphology AV-PVP-Thymol-I2. We evaluated inhibitory effects this 10 selected reference strains using impregnated sterile discs, surgical sutures, gauze bandages, face masks, KN95 masks. antimicrobial properties AV-PVP-Thymol-I2 assessed disc diffusion comparison with two common antibiotics. 25-month-old exhibited slightly lower zones, indicating changes sustained-iodine-release reservoir. Our findings confirm potent antifungal antibacterial agent strains, demonstrating strong action on cotton These results enable potential use promising wound spray-on contact-killing agent.

Язык: Английский

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Nutritional Composition, Phytochemical Profile, Therapeutic Potentials, and Food Applications of Rosemary: A Comprehensive Review

Journal of Food Composition and Analysis, Год журнала: 2024, Номер 135, С. 106688 - 106688

Опубликована: Авг. 28, 2024

Язык: Английский

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Comprehensive Ethnopharmacological Analysis of Medicinal Plants in the UAE: Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, Allium sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, and Ziziphus lotus

Nutrients, Год журнала: 2025, Номер 17(3), С. 411 - 411

Опубликована: Янв. 23, 2025

The United Arab Emirates (UAE) is home to diverse indigenous medicinal plants traditionally used for centuries. This study systematically evaluates the pharmacological and nutritional potential of key plants, including Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, lotus. Comprehensive literature searches were conducted using PubMed, Scopus, Web Science identify studies relevant their uses. findings highlight therapeutic roles these in managing global health challenges such as gastrointestinal diseases, antimicrobial resistance through bioactive compounds like flavonoids, polyphenols, antioxidants. Additionally, contributions nutrition, essential vitamins minerals, are emphasized disease prevention promotion. While this research focuses on UAE, implications globally relevant, many also found traditional medicine across Asia, Africa, Europe. Integrating into healthcare systems offers solutions pressing public concerns, reduces reliance synthetic pharmaceuticals, promotes sustainable practices. work a valuable reference researchers, professionals, policymakers, bridging knowledge modern scientific applications globally.

Язык: Английский

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Ätherische Öle und Aromatherapie – Grundlagen und Ergebnisse

Zeitschrift für Komplementärmedizin, Год журнала: 2025, Номер 17(01), С. 20 - 23

Опубликована: Фев. 1, 2025

Summary Die Erfahrung zeigt, dass ätherische Öle das Wohlbefinden fördern und Selbstheilungskräfte stärken können. Verwendung ätherischer erfordert Kenntnisse über ihre Biochemie sichere Anwendung mit Trägersubstanzen. Forschungsergebnisse belegen die antimikrobielle Wirkung vieler gegen verschiedene Bakterien Pilze. Trotz vielversprechender Ergebnisse stehen der Entwicklung von aromatischen Antibiotika Herausforderungen gegenüber wie mangelnde Haltbarkeit therapeutische Breite zwischen Wirksamkeit Unverträglichkeit.

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Unveiling metabolome heterogeneity in seed and husk from three cardamom species for quality control and valorization purposes of its waste products via NMR-based metabolomics in relation to in vitro biological effects

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143687 - 143687

Опубликована: Март 1, 2025

Язык: Английский

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Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1–21) Confers Activity against Staphylococcus aureus, Including Drug-Resistant and Biofilm Phenotype

ACS Infectious Diseases, Год журнала: 2024, Номер 10(7), С. 2403 - 2418

Опубликована: Июнь 7, 2024

Staphylococcus aureus, a bacterium resistant to multiple drugs, is significant cause of illness and death worldwide. Antimicrobial peptides (AMPs) provide an excellent potential strategy cope with this threat. Recently, we characterized derivative the frog-skin AMP esculentin-1a, Esc(1-21) (1) that endowed potent activity against Gram-negative bacteria but poor efficacy Gram-positive strains. In study, three analogues peptide 1 were designed by replacing Gly8 α-aminoisobutyric acid (Aib), Pro, dPro (2-4, respectively). The single substitution → Aib8 in 2 makes it active planktonic form bacterial strains, especially including multidrug-resistant clinical isolates, improved biostability without resulting cytotoxicity mammalian cells. Moreover, showed higher antibiofilm than both reference isolates S. aureus. Peptide was also able induce rapid killing, suggesting membrane-perturbing mechanism action. Structural analysis most evidenced biological consequence combination biostability, α helical content, ability reduce membrane fluidity adopt distorted helix, bent correspondence Aib8. Overall, study has shown how strategic amino sufficient enlarge spectrum original 1, improve its properties for therapeutic purposes, thus paving way optimize AMPs development new broad-spectrum anti-infective agents.

Язык: Английский

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