International journal of basic science in medicine,
Год журнала:
2024,
Номер
9(1), С. 36 - 44
Опубликована: Март 27, 2024
The
spectrum
of
diseases
caused
by
intracellular
bacterial
pathogens
(IBPs)
is
broad,
ranging
from
life-threatening
conditions
such
as
tuberculosis
to
other
infectious-transmitted
diseases.
Conventional
antibiotic
treatment
faces
challenges
due
resistance,
host
cell
toxicity,
and
limited
drug
penetration.
Despite
the
excellent
ability
these
perilous
modulate
biology,
localize
in,
multiply
through
targeting
key
virulence
factors,
brings
about
auspicious
maneuvers
combat
pathogenic
alleviate
their
significant
global
burden.
Modulation
identification
molecules,
pathways,
responses
are
initial
steps
targeted
therapy,
varying
disease
disease.
This
article
explores
cutting-edge
advancements
in
therapy
approaches.
Innovations
nanoparticlebased
delivery
systems,
phage
immunomodulation,
gene
editing,
which
hold
a
promising
future
for
overcoming
limitations
traditional
treatment,
also
discussed.
Efficient
optimizations,
inch-perfect
distribution
retention
therapeutic
agents
some
determining
factors
success
pathogens.
presents
novel
application
wherein
filamentous
phages
loaded
targets
nanocarriers
purposes.
present
faced
researchers,
along
with
directions
this
field
medical
science,
outlined.
Overall,
scope
involves
various
strategies
involved
modulations,
our
current
Plants,
Год журнала:
2024,
Номер
13(5), С. 613 - 613
Опубликована: Фев. 23, 2024
The
application
of
biostimulants
has
been
proven
to
be
an
advantageous
tool
and
appropriate
form
management
towards
the
effective
use
natural
resources,
food
security,
beneficial
effects
on
plant
growth
yield.
Plant-growth-promoting
rhizobacteria
(PGPR)
are
microbes
connected
with
roots
that
can
increase
by
different
methods
such
as
producing
hormones
molecules
improve
or
providing
increased
mineral
nutrition.
They
colonize
all
ecological
niches
stages
crop
development,
they
affect
development
directly
modulating
hormone
levels
enhancing
nutrient
acquisition
potassium,
phosphorus,
nitrogen,
essential
minerals,
indirectly
via
reducing
inhibitory
impacts
pathogens
in
forms
biocontrol
parameters.
Many
plant-associated
species
Pseudomonas,
Acinetobacter,
Streptomyces,
Serratia,
Arthrobacter,
Rhodococcus
improving
disease
resistance,
synthesizing
growth-stimulating
hormones,
suppressing
pathogenic
microorganisms.
is
both
environmentally
friendly
practice
a
promising
method
enhance
sustainability
horticultural
agricultural
production
systems
well
promote
quantity
quality
foods.
also
reduce
global
dependence
hazardous
chemicals.
Science
Direct,
Google
Scholar,
Springer
Link,
CAB
Scopus,
Taylor
Francis,
Web
Science,
Wiley
Online
Library
were
checked,
search
was
conducted
manuscript
sections
accordance
terms
Enterobacter,
Ochrobactrum,
Rhodococcus,
Biostimulants,
Plant
promoting
rhizobactera,
Stenotrophomonas.
aim
this
survey
plant-growth-promoting
presenting
case
studies
successful
paradigms
various
crops.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6798 - 6798
Опубликована: Июнь 20, 2024
The
necrotrophic
plant
pathogenic
fungus
Botrytis
cinerea
(Pers.,
1794),
the
causative
agent
of
gray
mold
disease,
causes
significant
losses
in
agricultural
production.
Control
this
fungal
pathogen
is
quite
difficult
due
to
its
wide
host
range
and
environmental
persistence.
Currently,
management
disease
still
mainly
based
on
chemicals,
which
can
have
harmful
effects
not
only
environment
human
health
but
also
because
they
favor
development
strains
resistant
fungicides.
flexibility
plasticity
B.
challenging
defense
mechanisms
ability
evolve
strategies
escape
chemicals
require
new
control
for
successful
management.
In
review,
some
aspects
host-pathogen
interactions
from
novel
sustainable
could
be
developed
(e.g.,
signaling
pathways,
molecules
involved
immune
mechanisms,
hormones,
post-transcriptional
gene
silencing)
were
analyzed.
New
biotechnological
tools
use
RNA
interference
(RNAi)
are
emerging
crop
protection
scenario
as
versatile,
sustainable,
effective,
environmentally
friendly
alternatives
chemicals.
RNAi-based
fungicides
expected
approved
soon,
although
will
face
several
challenges
before
reaching
market.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 26, 2024
Antimicrobial
peptides
(AMPs),
commonly
referred
to
as
host
defense
peptides,
are
found
in
a
wide
range
of
organisms,
including
bacteria,
plants,
and
both
vertebrate
invertebrate
animals.
They
function
an
initial
mechanism
against
pathogenic
microorganisms,
modulate
immune
responses,
specific
instances,
confer
protection
the
onset
cancer.
Pleurocidin
(Ple)
is
linear
antimicrobial
peptide
with
amphipathic
α-helical
conformation,
isolated
originally
from
winter
flounder
(Pleuronectes
americanus),
notable
for
its
wide-ranging
effectiveness
bacteria
fungi.
While
majority
research
on
pleurocidin's
biological
characteristics
has
primarily
focused
deciphering
mechanisms
interaction
membranes
cells,
well
investigating
modes
killing
activities,
there
growing
body
evidence
suggesting
that
pleurocidin
pleurocidin-derived
analogs
might
be
effectively
employed
anti-cancer
agents
breast
carcinoma
leukemia
due
their
potent
cytotoxic
properties
selectivity
towards
cancer
cells.
Notably,
some
observed
microbiological
investigations
this
compound
could
applied
examining
capabilities
Ple-like
derivatives.
This
review
provides
comprehensive
overview
literature
activities
pleurocidin,
pleurocidin-containing
hybrid
nanosystems.
The
primary
emphasis
elucidating
exhibited
by
these
compounds,
evaluating
potential
therapeutic
applications,
assessing
safety
profile,
identifying
any
limits
thus
far.
paper
will
also
discuss
areas
further
investigation
into
effects
Ple
derivatives,
drawing
insights
research.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2023,
Номер
42(23), С. 13091 - 13099
Опубликована: Окт. 26, 2023
Hybridization
of
Antimicrobial
peptides
(AMPs)
with
unique
abilities
is
now
considered
to
improve
AMPs'
function
as
promising
therapeutic
candidates.
In
the
current
research,
Lasioglossin
(LL-III)
a
high
antimicrobial
effect
on
Acinetobacter
(A.)
baumanni
and
Melittin
against
Staphylococcus
(S.)
aureus
were
selected
for
designing
hybrid
peptide
modified
properties.
present
study,
properties
was
designed.
Molecular
dynamic
(MD)
coarse-grained
(CG)
simulations
done
evaluate
stability
interaction
related
membrane
models.
this
truncated
(11
amino
acids)
fused
an
LL-III
(15
raise
activity.
A
new
analog
(LM1)
by
replacing
arginine
isoleucine
in
fifth
position
rate
peptide.
The
potential
binding
LM1
lipid
(D
factor)
increased
from
2.02
3.62.
Based
VMD
results,
N-terminal
alpha
helix
during
200
ns.
However,
C-terminal
region
only
at
50
ns
form.
RMSD
range
0.2
0.8,
which,
after
160
ns,
reached
stability.
RMSF
results
indicated
no
unwanted
fluctuations
MD
simulation.
significant
movement
inside
S.
membrane(4.76
nm)
A.
(3.2
observed
CG
Our
findings
highlight
designed
its
halter
baumanii
bacteria.
Horticulture Research,
Год журнала:
2024,
Номер
11(10)
Опубликована: Июль 30, 2024
Developing
disease-suppressive
soils
is
an
effective
approach
for
managing
soilborne
diseases,
which
can
be
achieved
through
crop
metabolism
and
root
secretion
modification
to
recruit
beneficial
soil
microbiota.
Many
factors,
such
as
light,
elicit
modify
plant
metabolomic
activities,
resulting
in
disease
suppression.
To
investigate
the
impact
of
