The
psychosocial
factors
play
an
important
role
in
the
development
of
depression
adolescents.
we
used
metabolomics
techniques
to
explore
links
among
childhood
trauma,
rumination,
resilience,
and
adolescent
depression.
We
selected
57
patients
53
healthy
Childhood
Trauma
Questionnaire
(CTQ),
Hamilton
Depression
Scale
(HAMD),
Resilience
(CD-RISC),
Redundant
Thinking
Response
(RRS)
were
employed
for
purpose
psychological
assessment.
regrouped
according
their
scores
using
27%
high-low
grouping
method.
Blood
specimens
collected
from
all
adolescents
metabolic
data
obtained
LC-MS.
found
no
statistically
significant
difference
between
groups
terms
age,
gender,
body
mass
index
(BMI).
HAMD,
CTQ,
RRS
significantly
higher
group
(MDD)
than
control
(HC),
CD-RISP
lower
HC
(P
<
0.001).
There
differences
low
trauma
(LCT)
high
(HCT),
rumination
(LRR)
(HRR),
resilience
(LPR)
(HPR)
RRS,
CTQ
HAMD
positively
correlated,
CD-RIS
was
negatively
correlated
with
0.01).
More
importantly,
that
DHEAS
LPA
(22:6)
identified
as
differential
metabolites
both
depressed
normal
groups,
well
groups.
N-Acetyl-L-aspartic
acid
Pseudouridine
LPA(22:6)
Psychological
(childhood
resilience)
are
biologically
linked
impact
on
may
be
associated
DHEA.
(22:6).
Receptors,
Год журнала:
2024,
Номер
3(1), С. 36 - 57
Опубликована: Фев. 20, 2024
The
involvement
of
the
prefrontal
cortical
dopaminergic
system
in
psychopathology
epilepsies
and
comorbid
conditions
such
as
autism
spectrum
disorder
(ASD)
still
needs
to
be
explored.
We
used
autoradiography
study
D1-like
(D1DR)
D2-like
(D2DR)
receptor
binding
density
cortex
normal
Wistar
rats
Wistar-derived
strains
with
generalized
convulsive
and/or
non-convulsive
epilepsy.
WAG/Rij
served
a
model
for
absence
epilepsy,
WAG/Rij-AGS
mixed
convulsive/non-convulsive
form,
KM
strain
was
epilepsy
an
ASD-like
behavioral
phenotype.
any
epileptic
pathology
studied
demonstrated
profound
decreases
densities
both
D1DR
D2DR;
effects
were
localized
primary
secondary
anterior
cingulate
cortices,
adjacent
regions.
local
decreased
D2DR
independent
(not
correlated
with)
each
other.
particular
group
phenotype
(KM
strain)
displayed
changes
lateral
cortex:
lowered,
whereas
elevated,
dysgranular
insular
Thus,
epilepsy-related
rat
archeocortex
medial
regions,
ASD-related
seen
aspects.
findings
point
putative
dysfunctions,
associated
ASD.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июль 12, 2024
Abstract
Background
Bilirubin
is
known
for
its
multifaceted
attributes,
including
antioxidant,
anti-inflammatory,
immunomodulatory,
and
antiapoptotic
properties.
The
systemic
immune-inflammation
index
(SII)
a
recent
marker
that
reflects
the
balance
between
inflammation
immune
response.
Despite
wealth
of
information
available
on
bilirubin’s
diverse
functionalities,
potential
correlation
total
bilirubin
(TB)
levels
SII
has
not
been
investigated
so
far.
Methods
Leveraging
data
from
National
Health
Nutrition
Examination
Survey
spanning
2009–2018,
TB
were
categorized
using
tertiles.
Employing
chi-squared
test
with
Rao
Scott’s
second-order
correction
Spearman’s
rank
analysis,
association
was
examined.
nonlinearities
evaluated
restricted
cubic
spline
(RCS)
analysis.
Weighted
linear
regression,
adjusted
covariates,
used
to
explore
SII,
further
subgroup
analyses.
Results
A
16,858
participants
included,
findings
revealed
significant
variations
across
tertiles
(
p
<
0.001).
third
tertile
(Q3)
exhibited
lowest
level
at
495.73
(295.00)
1000
cells/µL.
Spearman
disclosed
negative
SII.
RCS
analysis
exposed
lack
statistically
in
nonlinear
relationship
>
0.05),
thereby
providing
support
relationship.
regression
underscored
(β
95%
CI
−
3.9
[−
5.0
2.9],
increase
associated
trend
toward
decreasing
After
controlling
relative
this
increased
Subgroup
confirmed
TB–SII
.
Conclusion
notable
implies
protective
effects
inflammation-related
diseases.
Acta Epileptologica,
Год журнала:
2025,
Номер
7(1)
Опубликована: Янв. 10, 2025
Abstract
Febrile
infection-related
epilepsy
syndrome
(FIRES)
is
a
rare
with
unclear
pathogenesis,
characterized
by
fever-induced,
super-refractory
status
epilepticus
and
high
mortality.
Studies
have
shown
that
ketogenic
diet
(KD)
effective
in
controlling
convulsions
FIRES,
but
its
mechanisms
are
unclear.
This
paper
intends
to
summarize
the
which
KD
may
exert
effects
against
FIRES.
Clinical
studies
patients
FIRES
elevated
levels
of
various
inflammatory
factors
such
as
interleukin
(IL)-6,
IL-8,
IL-10,
so
on.
anti-FIRES
through
several
potential
pathways,
including
nuclear
factor
-κB
(NF-κB)
NLR
family
pyrin
domain
containing
3
(NLRP3).
Furthermore,
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
network
suggested
play
an
anti-inflammatory
role
pathways
cellular
senescence
neutrophil
extracellular
trap
formation.
These
need
be
further
investigated.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0320719 - e0320719
Опубликована: Март 27, 2025
Background
Postoperative
delirium
(POD)
is
one
of
the
most
common
complications
in
geriatric
patients
following
surgery.
Physiological
concentration
bilirubin
possesses
anti-inflammatory,
antioxidant
and
neuroprotective
effects,
which
are
important
protective
mechanisms
against
POD.
This
study
aimed
to
explore
relationship
between
preoperative
serum
POD
undergoing
joint
replacement.
Methods
Geriatric
who
underwent
hip
or
knee
replacement
surgery
under
intrathecal
anesthesia
were
included.
These
had
American
Society
Anesthesiologists
(ASA)
grades
I
III.
The
with
a
history
psychiatric
neurological
disorders,
infectious
diseases
sepsis,
hemolytic
anemia,
liver
diseases,
performed
general
combined
anesthesia,
insufficient
surgical
information
excluded.
Patients’
age,
gender,
weight,
height,
ASA
classification,
function
within
week
before
surgery,
Mini–Mental
State
Examination
(MMSE)
scores,
type,
dosage
medications,
intraoperative
bleeding
volume,
postoperative
average
numeric
rating
scale
(NRS)
pain
occurrence
Delirium
Rating
Scale–Revised–98
(DRS–R–98)
scores
for
collected.
Results
A
total
269
eligible
inclusion
study,
23.05%
(62/207)
exhibiting
Patients
exhibited
higher
age
lower
(TBIL)
indirect
(IBIL)
MMSE
(all
p
<
0.05).
Univariate
logistic
regression
analysis
showed
that
above
variables
correlated
Multivariate
revealed
was
risk
factor
(
0.001,
OR
=
1.14,
95%
CI
[1.07
–
1.21]),
while
weight
0.041,
0.96,
[0.92
0.99]),
IBIL
levels
0.012,
0.65,
[0.47–0.91])
0.84,
[0.78
0.91])
served
as
factors
receiver
operating
characteristic
(ROC)
curve
analysis.
estimated
cutoff
value
predicting
6.65
μmol/L,
area
(AUC)
0.63.
below
μmol/L
incidence
Conclusion
Low
predictor
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3060 - 3060
Опубликована: Март 27, 2025
Alzheimer's
disease
(AD)
and
vascular
dementia
(VaD)
are
the
two
most
prevalent
forms
of
dementia,
sharing
overlapping
clinical
features
yet
distinct
pathophysiological
mechanisms.
While
AD
is
primarily
driven
by
amyloid-beta
(Aβ)
plaques
tau
neurofibrillary
tangles,
VaD
results
from
cerebrovascular
pathology,
including
ischemic
lesions
chronic
hypoperfusion.
However,
accumulating
evidence
suggests
that
dysfunction
a
crucial
contributor
to
both
conditions,
bridging
neurodegenerative
pathologies.
In
this
review,
we
explore
interplay
between
VaD,
focusing
on
shared
pathways
such
as
blood-brain
barrier
(BBB)
breakdown,
neuroinflammation,
microvascular
damage.
Notably,
cerebral
microbleeds
have
emerged
common
feature
in
further
linking
pathology
neurodegeneration.
Microbleeding
contributes
BBB
disruption,
iron
deposition,
exacerbated
oxidative
stress,
creating
vicious
cycle
accelerates
cognitive
decline.
We
highlight
role
dysregulation
key
driver
AD,
exacerbating
Aβ
accumulation,
hyperphosphorylation,
ferroptosis.
Conversely,
bilirubin
emerges
molecule
with
theranostic
potential,
acting
biomarker
neuroprotective
agent
due
its
antioxidant
anti-inflammatory
properties.
Despite
protective
role,
bilirubin's
under
pathological
conditions
may
contribute
damage
neurovascular
dysfunction.
context,
accumulation
recurrent
disrupt
homeostasis,
amplifying
injury
inflammation.
propose
hypothesis
integrates
metabolism
suggesting
their
imbalance
plays
central
pathogenesis
worsening.
Understanding
intricate
molecular
neurodegeneration
could
provide
novel
insights
into
targeted
interventions
aimed
at
mitigating
Finally,
discuss
potential
bilirubin-based
therapeutic
strategies,
counteracting
stress
modulating
neuroinflammatory
pathways,
offering
promising
avenues
for
future
research
precision
medicine
dementia.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0320523 - e0320523
Опубликована: Март 28, 2025
Background
Brominated
flame
retardants
(BFRs)
are
harmful,
bioaccumulative,
and
persistent
environmental
pollutants,
posing
significant
health
risks.
Elevated
bilirubin
levels
can
cause
neurotoxicity
damage
to
the
heart,
liver,
kidneys,
other
organs.
This
study
utilizes
National
Health
Nutrition
Examination
Survey
(NHANES)
data
investigate
association
between
exposure
BFRs
total
(TB)
in
adult
participants.
Methods
Based
on
from
NHANES
2007-2016,
TB
were
divided
into
tertiles.
Spearman’s
rank
correlation
was
used
analyze
relationship
individual
levels.
Weighted
linear
regression
analysis,
restricted
cubic
splines
(RCS),
stratified
analysis
conducted
assess
quantile
sum
(WQS)
quantile-based
g-computation
(QGC)
comprehensively
evaluate
impact
of
serum
Results
The
included
5831
results
showed
that
PBB153,
PBDE17,
PBDE47,
PBDE85,
PBDE99,
PBDE100,
PBDE209,
PBDE183
significantly
correlated
with
(
p
<
0.05),
having
highest
Spearman
coefficient
0.292.
After
adjusting
for
confounding
factors,
most
BFR
remained
positively
TB,
while
PBDE153
(β:
-
0.031,
95%CI:
0.317,
0.255,
=
0.829)
PBDE66
0.285,
0.208,
0.777,
0.253)
not
statistically
significant.
RCS
indicated
concentration
had
a
U-shaped
PBDE154,
PBDE209
an
inverted
“J”-shaped
0.05).
PBDE66,
also
exhibited
nonlinear
S-shaped
correlations
stratification
by
age
gender,
WQS
QGC
mixed
0.553,
0.384,
0.722,
0.001
β:
1.060,
0.587,
1.532,
0.001),
contributing
most.
Conclusions
is
levels,
further
suggesting
potential
humans.
