Aim
This
study
aimed
to
compare
the
antidiabetic
effect
of
metal
oxide
nanoparticles
(CuONPs
and
ZnONPs)
prepared
using
lemongrass
mint
herbal
formulations.
Introduction
The
explores
green-synthesized
for
potential
applications
in
diabetes
management,
emphasizing
sustainable
synthesis
methods,
particularly
zinc
(ZnONPs)
copper
(CuONPs)
produced
from
was
prompted
by
increasing
importance
innovative
therapeutic
strategies,
responding
emerging
health
challenges,
leveraging
advancements
nanotechnology
eco-friendly
practices
explore
management.
Methods
methods
involve
formulation
preparation,
CuONPs
ZnONPs
synthesis,
UV-visible
spectrophotometry
characterization.
In
vitro
activity
is
assessed
through
α-amylase
β-glucosidase
enzyme
assays
varied
nanoparticle
concentrations
(10-50
µL).
Results
Visual
observations
confirm
successful
with
distinct
color
changes
observed
both
after
24
hours.
reveals
absorption
peaks
at
440
nm
380
ZnONPs,
respectively.
assay,
exhibit
concentration-dependent
inhibition,
ranging
40%
77%
36%
80%.
assay
demonstrates
similar
inhibition
patterns,
highlighting
significant
differences.
Conclusion
concludes
that
formulations
show
activity.
comparative
analysis
underscores
need
tailored
approaches
based
on
composition.
These
findings
contribute
valuable
insights
into
nanoparticles,
paving
way
future
nanomedicine
research
development
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 11, 2024
Abstract
The
antifungal
efficacy
and
cytotoxicity
of
a
novel
nano-antifungal
agent,
the
Fe
3
O
4
@SiO
2
/Schiff-base
complex
Cu(II)
magnetic
nanoparticles
(MNPs),
have
been
assessed
for
targeting
drug-resistant
Candida
species.
Due
to
rising
issue
fungal
infections,
especially
candidiasis,
resistance
traditional
antifungals,
there
is
an
urgent
need
new
therapeutic
strategies.
Utilizing
Schiff-base
ligands
known
their
broad-spectrum
antimicrobial
activity,
/Schiff-base/Cu(II)
MNPs
synthesized.
was
characterized
by
Fourier
Transform-Infrared
Spectroscopy
(FT-IR),
X-ray
Diffraction
(XRD),
Transmission
Electron
Microscopy
(TEM),
Scanning
(SEM),
Dynamic
Light
Scattering
(DLS),
Energy-dispersive
(EDX),
Vibrating
Sample
Magnetometer
(VSM),
Thermogravimetric
analysis
(TGA),
demonstrating
successful
synthesis.
potential
evaluated
against
six
species
(
C
.
dubliniensis
,
krusei
tropicalis
parapsilosis
glabrata
albicans
)
using
broth
microdilution
method.
results
indicated
strong
activity
in
range
8–64
μg/mL
with
lowest
MIC
(8
μg/mL)
observed
result
showed
32
C.
as
most
common
infection
source.
mechanism
likely
due
disruption
cell
wall
membrane,
along
increased
reactive
oxygen
(ROS)
generation
leading
death.
MTT
(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium
bromide)
assay
on
mouse
L929
fibroblastic
cells
suggested
low
toxicity
even
enhanced
proliferation
at
certain
concentrations.
This
study
demonstrates
promise
potent
agent
applications
treatment
life-threatening
healthcare-associated
beyond.
Biomimetics,
Год журнала:
2024,
Номер
9(3), С. 154 - 154
Опубликована: Март 1, 2024
The
incidence
of
microbial
infections
in
orthopedic
prosthetic
surgeries
is
a
perennial
problem
that
increases
morbidity
and
mortality,
representing
one
the
major
complications
such
medical
interventions.
emergence
novel
technologies,
especially
3D
printing,
represents
promising
avenue
development
for
reducing
risk
eventualities.
There
are
already
host
biomaterials,
suitable
being
tested
antimicrobial
properties
when
they
coated
with
bioactive
compounds,
as
antibiotics,
or
combined
hydrogels
antioxidant
properties,
chitosan
metal
nanoparticles,
among
others.
materials
discussed
context
this
paper
comprise
beta-tricalcium
phosphate
(β-TCP),
biphasic
calcium
(BCP),
hydroxyapatite,
lithium
disilicate
glass,
polyetheretherketone
(PEEK),
poly(propylene
fumarate)
(PPF),
poly(trimethylene
carbonate)
(PTMC),
zirconia.
While
recent
research
results
promising,
further
required
to
address
increasing
antibiotic
resistance
exhibited
by
several
common
pathogens,
potential
fungal
infections,
toxicity
some
nanoparticles.
Other
solutions,
like
incorporation
phytochemicals,
should
also
be
explored.
Incorporating
artificial
intelligence
(AI)
certain
implants
use
AI
against
bacterial
might
represent
viable
solutions
these
problems.
Finally,
there
legal
considerations
associated
biomaterials
widespread
which
must
taken
into
account.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12889 - 12937
Опубликована: Дек. 1, 2024
Abstract:
Over
the
last
decade,
biomedical
nanomaterials
have
garnered
significant
attention
due
to
their
remarkable
biological
properties
and
diverse
applications
in
biomedicine.
Metal
oxide
nanoparticles
(NPs)
are
particularly
notable
for
wide
range
of
medicinal
uses,
including
antibacterial,
anticancer,
biosensing,
cell
imaging,
drug/gene
delivery.
Among
these,
zinc
(ZnO)
NPs
stand
out
versatility
effectiveness.
Recently,
ZnO
become
a
primary
material
various
sectors,
such
as
pharmaceutical,
cosmetic,
antimicrobials,
construction,
textile,
automotive
industries.
can
generate
reactive
oxygen
species
induce
cellular
apoptosis,
thus
underpinning
potent
anticancer
antibacterial
properties.
To
meet
growing
demand,
numerous
synthetic
approaches
been
developed
produce
NPs.
However,
traditional
manufacturing
processes
often
involve
economic
environmental
costs,
prompting
search
more
sustainable
alternatives.
Intriguingly,
synthesis
methods
utilizing
plants,
plant
extracts,
or
microorganisms
emerged
ideal
producing
These
green
production
techniques
offer
medicinal,
economic,
environmental,
health
benefits.
This
review
highlights
latest
advancements
applications,
showcasing
potential
revolutionize
field
with
eco-friendly
cost-effective
solutions.
Keywords:
antimicrobial,
antioxidant,
synthesis,
nanomedicine,
nanoparticle,
Antibiotics,
Год журнала:
2025,
Номер
14(3), С. 253 - 253
Опубликована: Март 1, 2025
Background/Objectives:
Antimicrobial
resistance
(AMR)
poses
a
significant
public
health
threat,
leading
to
increased
mortality.
The
World
Health
Organization
has
established
priority
list
highlighting
critical
multidrug-resistant
(MDR)
pathogens
that
demand
urgent
research
on
antimicrobial
treatments.
Considering
this
and
the
fact
new
antibiotics
are
only
sporadically
approved,
natural
antibacterial
agents
have
seen
resurgence
in
interest
as
potential
alternatives
conventional
chemotherapeutics.
Natural
antibacterials,
derived
from
microorganisms,
higher
fungi,
plants,
animals,
minerals,
food
sources,
offer
diverse
mechanisms
of
action
against
MDR
pathogens.
Here,
we
present
comprehensive
summary
including
brief
history
their
application
key
strategies
for
using
microorganisms
(microbiopredators,
such
bacteriophages),
plant
extracts
essential
oils,
minerals
(e.g.,
silver
copper),
well
compounds
animal
origin,
milk
or
even
venoms.
review
also
addresses
role
prebiotics,
probiotics,
peptides,
novel
formulations
nanoparticles.
these
compounds,
terpenoids,
alkaloids,
phenolic
explored
alongside
challenges
application,
e.g.,
extraction,
formulation,
pharmacokinetics.
Conclusions:
Future
should
focus
developing
eco-friendly,
sustainable
validating
safety
efficacy
through
clinical
trials.
Clear
regulatory
frameworks
integrating
into
practice.
Despite
challenges,
sources
transformative
combating
AMR
promoting
solutions.
BMC Complementary Medicine and Therapies,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июнь 20, 2024
Abstract
Iron
nanoparticles
comprise
a
significant
class
of
inorganic
nanoparticles,
which
discover
applications
in
various
zones
by
prudence
their
few
exciting
properties.
This
study
achieved
the
green
synthesis
iron
oxide
(IONPs)
black
cumin
seed
(
Nigella
sativa
)
extract,
acts
as
reducing
and
capping
agent.
The
extract
were
synthesized
three
different
concentrations:
(01:01,
02:04,01:04).
UV-visible
spectroscopy,
XRD,
FTIR,
AFM
characterized
nanoparticles.
spectra
show
maximum
absorbance
peak
01:01
concentration
at
380
nm.
other
concentrations,
such
02:04,
peaked
400
nm
01:04
680
nm,
confirming
formation
analysis
reveals
spherical
shape
XRD
reveal
(fcc)
cubic
crystal
structure
FTIR
analysis’s
peaks
457.13,
455.20,
457.13
cm-1
depict
characteristic
nanoparticle
synthesis.
extract-mediated
substantial
antibacterial,
antifungal,
antioxidant
anti-inflammatory
activity
dose-dependent
manner.
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 645 - 645
Опубликована: Май 10, 2024
In
recent
years,
nanotechnology
has
achieved
a
remarkable
status
in
shaping
the
future
of
biological
applications,
especially
combating
fungal
diseases.
Owing
to
excellence
nanotechnology,
iron
nanoparticles
(Fe
NPs)
have
gained
enormous
attention
years.
this
review,
we
provided
comprehensive
overview
Fe
NPs
covering
key
synthesis
approaches
and
underlying
working
principles,
factors
that
influence
their
properties,
essential
characterization
techniques,
optimization
antifungal
potential.
addition,
diverse
kinds
NP
delivery
platforms
command
highly
effective
release,
with
fewer
toxic
effects
on
patients,
are
great
significance
medical
field.
The
issues
biocompatibility,
toxicity
profiles,
applications
optimized
field
biomedicine
also
been
described
because
these
most
significant
determining
inclusion
clinical
use.
Besides
this,
difficulties
regulations
exist
transition
from
laboratory
experimental
studies
(toxicity,
specific
standards,
safety
concerns)
NPs-based
agents
summarized.
