The Nano Revolution, Metal Nanoparticles in Antibiotic-Resistant Era DOI

Shilpa Rudra,

Danie Kingsley

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 91 - 142

Published: April 25, 2025

Nanoparticle synthesis has gained significant interest over the years because of its unique characteristics and sustainable productive applications in numerous fields. Metals exhibiting a friend-foe relationship with bacteria, possess potential to inhibit their growth specific forms concentrations. The increase antimicrobial resistance recent drawn attention. Top-down Bottom-up are two approaches metal nanoparticle synthesis. Gold, silver, copper, etc. have been used medical fields from ancient times. Although these conventional methods creating nanoparticles effective adaptable, they very negative effects. On other hand, green provides an economical environmentally beneficial substitute by using natural resources. To address current problem resistance, this review highlights activity contributions sustainability, safety efficiency production as well process, benefits, drawbacks.

Language: Английский

Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species DOI Creative Commons
Sedigheh Azadi,

Esmat Azizipour,

Ali Mohammad Amani

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 11, 2024

Abstract The antifungal efficacy and cytotoxicity of a novel nano-antifungal agent, the Fe 3 O 4 @SiO 2 /Schiff-base complex Cu(II) magnetic nanoparticles (MNPs), have been assessed for targeting drug-resistant Candida species. Due to rising issue fungal infections, especially candidiasis, resistance traditional antifungals, there is an urgent need new therapeutic strategies. Utilizing Schiff-base ligands known their broad-spectrum antimicrobial activity, /Schiff-base/Cu(II) MNPs synthesized. was characterized by Fourier Transform-Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning (SEM), Dynamic Light Scattering (DLS), Energy-dispersive (EDX), Vibrating Sample Magnetometer (VSM), Thermogravimetric analysis (TGA), demonstrating successful synthesis. potential evaluated against six species ( C . dubliniensis , krusei tropicalis parapsilosis glabrata albicans ) using broth microdilution method. results indicated strong activity in range 8–64 μg/mL with lowest MIC (8 μg/mL) observed result showed 32 C. as most common infection source. mechanism likely due disruption cell wall membrane, along increased reactive oxygen (ROS) generation leading death. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay on mouse L929 fibroblastic cells suggested low toxicity even enhanced proliferation at certain concentrations. This study demonstrates promise potent agent applications treatment life-threatening healthcare-associated beyond.

Language: Английский

Citations

26
Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction DOI Creative Commons
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

Citations

17
Nature’s Arsenal: Uncovering Antibacterial Agents Against Antimicrobial Resistance DOI Creative Commons
Ina Gajić, Dušan Kekić, Marko Janković

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 253 - 253

Published: March 1, 2025

Background/Objectives: Antimicrobial resistance (AMR) poses a significant public health threat, leading to increased mortality. The World Health Organization has established priority list highlighting critical multidrug-resistant (MDR) pathogens that demand urgent research on antimicrobial treatments. Considering this and the fact new antibiotics are only sporadically approved, natural antibacterial agents have seen resurgence in interest as potential alternatives conventional chemotherapeutics. Natural antibacterials, derived from microorganisms, higher fungi, plants, animals, minerals, food sources, offer diverse mechanisms of action against MDR pathogens. Here, we present comprehensive summary including brief history their application key strategies for using microorganisms (microbiopredators, such bacteriophages), plant extracts essential oils, minerals (e.g., silver copper), well compounds animal origin, milk or even venoms. review also addresses role prebiotics, probiotics, peptides, novel formulations nanoparticles. these compounds, terpenoids, alkaloids, phenolic explored alongside challenges application, e.g., extraction, formulation, pharmacokinetics. Conclusions: Future should focus developing eco-friendly, sustainable validating safety efficacy through clinical trials. Clear regulatory frameworks integrating into practice. Despite challenges, sources transformative combating AMR promoting solutions.

Language: Английский

Citations

2
Fusarium oxysporum mediated synthesis of nitrogen-doped carbon supported platinum nanoparticles for supercapacitor device and dielectric applications DOI
Azam Raza, Sk Najrul Islam,

Kaifee Sayeed

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

9
Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review DOI Creative Commons
Mohamed T. El‐Saadony, Guihong Fang, Si Yan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937

Published: Dec. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Language: Английский

Citations

9
From waste to Innovation: Silver-Doped silicate ink coating from waste coal fly ash for hydrophobic antimicrobial fabric and Water-Oil separation DOI
Zawar Hussain,

Adil Saleem,

Lizhen Gao

et al.

Waste Management, Journal Year: 2025, Volume and Issue: 194, P. 238 - 248

Published: Jan. 17, 2025

Language: Английский

Citations

1
Comprehensive Ethnopharmacological Analysis of Medicinal Plants in the UAE: Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, Allium sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, and Ziziphus lotus DOI Open Access

Rola Almasri,

Alaa S. Bedir,

Seham M. Al Raish

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 411 - 411

Published: Jan. 23, 2025

The United Arab Emirates (UAE) is home to diverse indigenous medicinal plants traditionally used for centuries. This study systematically evaluates the pharmacological and nutritional potential of key plants, including Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, lotus. Comprehensive literature searches were conducted using PubMed, Scopus, Web Science identify studies relevant their uses. findings highlight therapeutic roles these in managing global health challenges such as gastrointestinal diseases, antimicrobial resistance through bioactive compounds like flavonoids, polyphenols, antioxidants. Additionally, contributions nutrition, essential vitamins minerals, are emphasized disease prevention promotion. While this research focuses on UAE, implications globally relevant, many also found traditional medicine across Asia, Africa, Europe. Integrating into healthcare systems offers solutions pressing public concerns, reduces reliance synthetic pharmaceuticals, promotes sustainable practices. work a valuable reference researchers, professionals, policymakers, bridging knowledge modern scientific applications globally.

Language: Английский

Citations

1
Eco-Friendly Production of Antimicrobial Nanoparticles for Sustainability DOI
Arunima Biswas,

Jibanjyoti Panda,

Amilia Nongbet

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

1
Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases DOI Creative Commons

Habiba lawal,

Shamsaldeen Ibrahim Saeed, Mohammed Sani Gaddafi

et al.

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.

Language: Английский

Citations

1
Black seed assisted synthesis, characterization, free radical scavenging, antimicrobial and anti-inflammatory activity of iron oxide nanoparticles DOI Creative Commons

Rajeshkumar Shanmugam,

Tharani Munusamy,

Shahabe Saquib Abullais

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 20, 2024

Abstract Iron nanoparticles comprise a significant class of inorganic nanoparticles, which discover applications in various zones by prudence their few exciting properties. This study achieved the green synthesis iron oxide (IONPs) black cumin seed ( Nigella sativa ) extract, acts as reducing and capping agent. The extract were synthesized three different concentrations: (01:01, 02:04,01:04). UV-visible spectroscopy, XRD, FTIR, AFM characterized nanoparticles. spectra show maximum absorbance peak 01:01 concentration at 380 nm. other concentrations, such 02:04, peaked 400 nm 01:04 680 nm, confirming formation analysis reveals spherical shape XRD reveal (fcc) cubic crystal structure FTIR analysis’s peaks 457.13, 455.20, 457.13 cm-1 depict characteristic nanoparticle synthesis. extract-mediated substantial antibacterial, antifungal, antioxidant anti-inflammatory activity dose-dependent manner.

Language: Английский

Citations

8