The interplay between vitamin D status, subclinical inflammation, and prediabetes DOI Creative Commons

Ahmed Arabi,

Dima Nasrallah, Sara Mohsen

и другие.

Heliyon, Год журнала: 2024, Номер 10(15), С. e35764 - e35764

Опубликована: Авг. 1, 2024

Vitamin D's role extends beyond classical calcium and phosphate homeostasis to encompass a pivotal influence on immune modulation metabolic health. The mechanisms by which vitamin D exerts these effects involve its conversion hormonally active calcitriol, binds intracellular receptors, initiating various downstream cascades. In this review, we tease out the evidence showing relationship between deficiency prediabetes within context of subclinical inflammation, with special focus novel monocyte-to-HDL ratio (MHR), inflammatory marker reflecting inflammation. This was based thorough literature review using reputable databases covering period from 1980 2024. light this, discuss calcitriol's anti-inflammatory consequently link both overt Additionally, utility several biomarkers, notably MHR, in investigating association is also discussed. We further reviewed precipitating type 2 diabetes mellitus (T2DM) via insulin resistance, decreased synthesis secretion, Taken together, mini highlights that significantly associated playing critical development progression T2DM. Addressing through appropriate interventions may serve as preventative measure against

Язык: Английский

Multivitamin supplementation and its impact in metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Tom Ryu, Seung Yun Chae, Jae Jun Lee

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 13, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging global health concern with limited therapeutic options. Multivitamins, widely consumed dietary supplements, have been proposed to modulate oxidative stress and inflammation, potentially impacting MASLD progression. However, their efficacy in reducing mortality other complications remains unclear. Using data from the UK Biobank 7 years of median follow-up period, this study assessed association between multivitamin use outcomes, including all-cause mortality, liver-related cardio-cerebrovascular (CVD), chronic kidney (CKD), individuals those without disease. Inverse probability treatment weighting (IPTW) was employed adjust for confounders. Multivitamin users showed a significantly lower risk cohort both before (HR: 0.88, 95% CI 0.81–0.95, P = 0.034) after 0.94, 0.88–1.00, 0.037) IPTW adjustment. also associated CVD 0.72, 0.68–0.76, < 0.001) CKD 0.73, 0.67–0.81, cohort. No significant reduction found or cirrhosis incidence. These findings suggest that multivitamins might provide broader protective effects populations metabolic dysfunction. Further research needed clarify role liver-specific outcomes.

Язык: Английский

Процитировано

1
Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach DOI Creative Commons
Virginia Boccardi

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 219, С. 111941 - 111941

Опубликована: Май 14, 2024

Sarcopenia, the age-related loss of skeletal muscle mass and function, poses a significant challenge in field gerontology, impacting health independence older adults. By synthesizing current research findings theoretical frameworks, this perspective elucidates multifaceted mechanisms underlying sarcopenia, mainly focusing on energy balance metabolic processes. Furthermore, manuscript explores implications sarcopenia overall outcomes, functional decline, quality life individuals.

Язык: Английский

Процитировано

5
Vitamin D—A New Therapeutic Target in the Management of Type 2 Diabetes Patients DOI Open Access
Oana Albai, Adina Braha, Bogdan Timar

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(5), С. 1390 - 1390

Опубликована: Фев. 28, 2024

: Vitamin D is a fat-soluble vitamin that prevents cardiovascular diseases and diabetes mellitus (DM). The present research aimed to study the impact of 25-hydroxyvitamin (25(OH)D) level on health status patients with type 2 DM (T2DM) hospitalized in "Pius Brînzeu" Emergency Clinical County University Hospital Timisoara, Romania.

Язык: Английский

Процитировано

4
Hyperhomocysteinemia is linked to MASLD DOI Creative Commons
Carlo De Matteis, Lucilla Crudele,

Ersilia Di Buduo

и другие.

European Journal of Internal Medicine, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

4
Molecular pathways and biological roles of melatonin and vitamin D; effects on immune system and oxidative stress DOI
Tooba Yousefi, Mohammad Yousef Memar, Amirreza Ahmadi Jazi

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113548 - 113548

Опубликована: Ноя. 2, 2024

Язык: Английский

Процитировано

4
The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights DOI Creative Commons
Zhuo Huang, Qinyan Yao,

Shuang Ma

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and homeostasis. Recent research highlights the intricate interactions between RNA, especially non-coding RNAs, regulating processes. Dysbiosis of has been linked to disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) heart disease. Microbial metabolites, including short-chain acids (SCFAs), modulate RNA expression, lipid metabolism, glucose regulation, inflammatory responses. Additionally, microRNAs (miRNAs) long RNAs (lncRNAs) serve critical regulators these processes, with emerging evidence showing that gut-derived metabolites affect post-transcriptional gene regulation. This review synthesizes current understanding microbiota-RNA axis its diseases. By exploring molecular mechanisms, particularly how microbiota-derived signals pathways, underscores potential targeting this for therapeutic interventions. Furthermore, it examines dysbiosis leads epigenetic changes m6A methylation, contributing pathogenesis. These insights offer new perspective on prevention treatment diseases, applications personalized medicine.

Язык: Английский

Процитировано

0
Hypovitaminosis D in patients with oral leukoplakia: insights from a cross-sectional study DOI Creative Commons
Andrea Maturana-Ramírez, Juan Aitken-Saavedra,

Dante Mora-Ferraro

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Фев. 6, 2025

Oral leukoplakia is one of the most frequent oral potentially malignant disorders. The present study aims to compare serum vitamin D levels between patients with and without leukoplakia, by smoking habit. This cross-sectional involved a group 45 cases control individuals. In both groups pathology report was done, for binary classification low- high-grade epithelial dysplasia employed. Serum 25(OH)D3 levels, data on status, age, gender, comorbidities, clinical pathological characteristics were collected groups. lower in median 19.1 ng/ml, while had 24.8 ng/ml. When subdividing each habit, case 19.4 ng/ml (IQR: 15.7-21.5 ng/ml), non-smoking 18.8 13.6-29.2 21.8 17.5-27.3 25.4 20.4-32.9 ng/ml) (p<0.05). comparing statistically significant differences found versus histopathological diagnosis showed no shows that OL compared those OL, which more evident group. Patients previously observed have hypovitaminosis D, assessing habits. finding suggests possible role deficiency development could be marked smokers. opens possibility future research as chemopreventive agent transformation evaluate relationship D.

Язык: Английский

Процитировано

0
Research Progress on the Mechanism and Treatment of Vitamin D and Recurrent Miscarriage DOI

江蓉 彭

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(01), С. 2270 - 2279

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Vitamin D deficiency in overweight patients: current strategies and practical aspects DOI
Т. Л. Каронова, В. В. Салухов, Larisa Dzeranova

и другие.

Problems of Endocrinology, Год журнала: 2025, Номер 71(1), С. 92 - 98

Опубликована: Янв. 27, 2025

On September 27, 2024, a discussion-based working meeting on the issue of vitamin D deficiency in patients with overweight and obesity was held Vladikavkaz.The aimed to evaluate relationship between deficiency, overweight, associated comorbidities, as well explore modern strategies practical approaches for managing such endocrinology practice. The resolution developed by its participants, comprising leading endocrinologists.

Язык: Английский

Процитировано

0
Vitamin D and Dapagliflozin Alleviate Renal Injury and Insulin Resistance in a Diet‐Induced Metabolic Syndrome Rat Model DOI Open Access

Xincai Hong,

Yongbin Ma,

Weihong Yang

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(3)

Опубликована: Март 1, 2025

Metabolic syndrome, primarily driven by high-fat/high-sugar (HF/HS) diets, is closely linked to insulin resistance and renal injury, leading serious complications such as type 2 diabetes mellitus diabetic nephropathy. This study explored the combined effects of Vitamin D (VD) dapagliflozin (Dap) on metabolic in an HF/HS diet-induced rat model syndrome. The combination therapy significantly improved sensitivity, reduced fasting blood glucose levels, alleviated injury markers urea nitrogen creatinine. It also attenuated inflammation, lipid accumulation, endoplasmic reticulum stress tissues, evidenced levels inflammatory cytokines key (GRP78 CHOP). Importantly, highlights novel synergistic potential VD Dap addressing these through complementary mechanisms. These findings suggest that this offers promising clinical for managing syndrome its progression severe complications.

Язык: Английский

Процитировано

0