Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles DOI Creative Commons

Salma Sameh,

Ahmed M. Elissawy, Eman Al‐Sayed

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 16, 2024

Introduction Cancer is the second most widespread cause of mortality following cardiovascular disorders, and it imposes a heavy global burden. Nowadays, herbal nutraceutical products with plethora bioactive metabolites represent foundation stone for development promising chemopreventive anticancer agents. Certain members family Malvaceae have traditionally been employed to relieve tumors. The literature concerning effects plant species along isolated cytotoxic phytometabolites was reviewed. Based on findings, comprehensive computational modelling studies were performed explore pharmacokinetic pharmacodynamic profiles reported present basis future plant-based drug discovery. Methods All available information about research in its retrieved from official sources. Extensive search carried out using keywords Malvaceae, cancer, cytotoxicity, mechanism signalling pathway. Pharmacokinetic study SWISS ADME model. Acute oral toxicity expressed as median lethal dose (LD 50 ) predicted Pro Tox 3.0 web tool. compounds docked AutoDock Vina platform against epidermal growth factor receptor (EGFR kinase enzyme) obtained Protein Data Bank. Molecular dynamic simulations MMGBSA calculations GROMACS 2024.2 gmx_MMPBSA tool v1.5.2. Results One hundred forty-five articles eligible study. Several tested showed safe properties. Also, molecular docking that possessed agreeable binding affinities EGFR enzyme. Tiliroside (25), boehmenan (30), H (31), isoquercetin (22) elicited highest affinity toward enzyme score −10.4, −10.2 −10.1 Kcal/mol compared reference erlotinib having equal −9 Kcal/mol. Additionally, 25 31 free energies −42.17 −42.68 Kcal/mol, respectively, comparable erlotinib. Discussion Overall, current presents helpful insights into properties belonging members. results intensify roles secondary medicinal plants fighting cancer.

Язык: Английский

Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis DOI

Longyue Zhou,

Shankang Chen,

Yuanyi Wei

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер 967, С. 176365 - 176365

Опубликована: Фев. 3, 2024

Язык: Английский

Процитировано

6
Investigating the biological significance of the TCM principle “promoting urination to regulate bowel movements” through the influence of the intestinal microbiota and their metabolites on the renal-intestinal axis DOI Creative Commons
Donglin Yu, Junxi Shen, Liwen Li

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 10, 2025

Treatment methods in traditional Chinese medicine (TCM) are foundational to their theoretical, methodological, formulaic, and pharmacological systems, significantly contributing syndrome differentiation therapy. The principle of "promoting urination regulate bowel movements" is a common therapeutic approach TCM. core concept the dispersion drainage water dampness, regulating relieve diarrhea," yet its scientific underpinning remains unclear. Modern medical treatment for watery diarrhea primarily focuses on electrolyte replenishment, as diuretics may lead dehydration other side effects. Some reports suggest that this TCM lacks validity. Microecology, an area associated with origins TCM, closely related development, diagnosis, diarrhea. renal-intestinal axis offers molecular biological basis examining pathological mechanisms, advancing targets such "treating intestine address kidney issues" highlighting interactions within "renal-intestinal microbiota-liquid metabolism" framework, thus providing endogenous mechanism support through kidney." An increasing number studies have shown intestinal microbiota metabolites, unique mediators, involved physiological changes body. Therefore, study explores relationship between fluid metabolism from perspective aiming elucidate mechanisms underlying clarify treating via axis. This research provides new insights microbiology.

Язык: Английский

Процитировано

0
A Narrative Review of Protective Effects of Natural Compounds Against Lipopolysaccharide‐Induced Injuries DOI Creative Commons
Akbar Anaeigoudari

Food Science & Nutrition, Год журнала: 2025, Номер 13(2)

Опубликована: Янв. 31, 2025

Lipopolysaccharide (LPS) is a large amphipathic glycoconjugate molecule in the cell wall of Gram-negative bacteria. This bacterial endotoxin binds to toll-like receptor 4 (TLR4) and stimulates inflammatory reactions oxidative stress. The current paper presents protective effects natural compounds against LPS-induced injuries. relevant findings were extracted from PubMed, Web Science, Scopus, Google Scholar databases beginning 2005 until end September 2023 employed. results vitro vivo studies indicated that thymoquinone, crocin, carvacrol, quercetin effectively attenuated damages via lowering level cytokines free radicals. These could also amplify antioxidant defense LPS by increasing activity enzymes such as superoxide dismutase (SOD) catalase (CAT). In addition, part these phytochemicals detrimental impacts attributed their ability downregulate TLR4 expression inhibit NF-κB signaling pathway. Briefly, mentioned review LPS-caused mainly are mediated anti-inflammatory activities.

Язык: Английский

Процитировано

0
Integrating Metabolomics and Network Analyses to Explore Mechanisms of Geum japonicum var. chinense Against Pulmonary Fibrosis: Involvement of Arachidonic Acid Metabolic Pathway DOI Open Access

Junyan Ran,

Qian Wang, Tao Lu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1462 - 1462

Опубликована: Фев. 10, 2025

Pulmonary fibrosis (PF) emerges as a significant pulmonary sequelae in the convalescent phase of coronavirus disease 2019 (COVID-19), with current strategies neither specifically preventive nor therapeutic. Geum japonicum var. chinense (GJC) is used traditional Chinese medicine to effectively treat various respiratory conditions. However, protective effects GJC against PF remains unclear. In present study, anti-PF effect aqueous extract was studied using mouse model induced by bleomycin (BLM). To characterize metabolite changes related and reveal therapeutic targets for extract, we performed metabolomic network analysis on mice lungs. Finally, key were then validated Western blotting. alleviated onset progression lung inhibiting inflammatory responses regulating oxidative stress levels. Integrating serum metabolomics analyses showed arachidonic acid (AA) pathway be most important metabolic PF. Further validation AA protein levels rise ALOX5, PTGS2, CYP2C9, PLA2G2A treatment regulated above programming. conclusion, promising botanical drug delay mice. The primary mechanism action associated comprehensive regulation metabolites expression pathway.

Язык: Английский

Процитировано

0
Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury DOI Creative Commons
Ling Chen,

Yanyan Deng,

Jing Hu

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 19, 2025

Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration novel medicinal treatments for AKI management remains vital. Substances medicine food homology (SMFH), referring substances having characteristics both medicine, have been applied in China thousands years.They could be used daily diets body conditioning. Traditional Chinese (TCM), naturally derived components demonstrated effectiveness, presents distinctive benefits treatment. Numerous studies shown that SMFH TCM phytochemicals function satisfactorily nephroprotective effects a effect on alleviating as well complications. In this review, pathogenesis was illustrated. We concentrated against tried summarize underlying mechanisms various kinds AKI, highlighting crucial phytochemical prevention therapy. Besides, strategies globalization are analysed. This review comprehensively reveals exhibit promising potential intervention by targeting signal pathways targets, which would contribute AKI's cognition, preventive treatments, global promotion.

Язык: Английский

Процитировано

0
Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles DOI Creative Commons

Salma Sameh,

Ahmed M. Elissawy, Eman Al‐Sayed

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 16, 2024

Introduction Cancer is the second most widespread cause of mortality following cardiovascular disorders, and it imposes a heavy global burden. Nowadays, herbal nutraceutical products with plethora bioactive metabolites represent foundation stone for development promising chemopreventive anticancer agents. Certain members family Malvaceae have traditionally been employed to relieve tumors. The literature concerning effects plant species along isolated cytotoxic phytometabolites was reviewed. Based on findings, comprehensive computational modelling studies were performed explore pharmacokinetic pharmacodynamic profiles reported present basis future plant-based drug discovery. Methods All available information about research in its retrieved from official sources. Extensive search carried out using keywords Malvaceae, cancer, cytotoxicity, mechanism signalling pathway. Pharmacokinetic study SWISS ADME model. Acute oral toxicity expressed as median lethal dose (LD 50 ) predicted Pro Tox 3.0 web tool. compounds docked AutoDock Vina platform against epidermal growth factor receptor (EGFR kinase enzyme) obtained Protein Data Bank. Molecular dynamic simulations MMGBSA calculations GROMACS 2024.2 gmx_MMPBSA tool v1.5.2. Results One hundred forty-five articles eligible study. Several tested showed safe properties. Also, molecular docking that possessed agreeable binding affinities EGFR enzyme. Tiliroside (25), boehmenan (30), H (31), isoquercetin (22) elicited highest affinity toward enzyme score −10.4, −10.2 −10.1 Kcal/mol compared reference erlotinib having equal −9 Kcal/mol. Additionally, 25 31 free energies −42.17 −42.68 Kcal/mol, respectively, comparable erlotinib. Discussion Overall, current presents helpful insights into properties belonging members. results intensify roles secondary medicinal plants fighting cancer.

Язык: Английский

Процитировано

1